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    Anti Adrenergic Drug1

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    Ravi Kaushik
    This document discusses adrenergic antagonists, which are drugs that inhibit the function of adrenergic receptors. It classifies these drugs based on their selectivity and affinity for α and β adrenergic receptors. Examples of non-selective α antagonists discussed include phentolamine, tolazoline, and phenoxybenzamine. Selective α-1 antagonists mentioned are prazosin, terazosin, and doxazosin. Propranolol and atenolol are presented as examples of non-selective and selective β antagonists respectively. The mechanisms of action and properties of several individual drugs are also outlined.

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    Anti Adrenergic Drug1

    Uploaded by

    Ravi Kaushik
    13 views13 pages
    This document discusses adrenergic antagonists, which are drugs that inhibit the function of adrenergic receptors. It classifies these drugs based on their selectivity and affinity for α and β adrenergic receptors. Examples of non-selective α antagonists discussed include phentolamine, tolazoline, and phenoxybenzamine. Selective α-1 antagonists mentioned are prazosin, terazosin, and doxazosin. Propranolol and atenolol are presented as examples of non-selective and selective β antagonists respectively. The mechanisms of action and properties of several individual drugs are also outlined.

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    This document discusses adrenergic antagonists, which are drugs that inhibit the function of adrenergic receptors. It classifies these drugs based on their selectivity and affinity for α and β adrenergic receptors. Examples of non-selective α antagonists discussed include phentolamine, tolazoline, and phenoxybenzamine. Selective α-1 antagonists mentioned are prazosin, terazosin, and doxazosin. Propranolol and atenolol are presented as examples of non-selective and selective β antagonists respectively. The mechanisms of action and properties of several individual drugs are also outlined.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    13 views13 pages

    Anti Adrenergic Drug1

    Uploaded by

    Ravi Kaushik
    This document discusses adrenergic antagonists, which are drugs that inhibit the function of adrenergic receptors. It classifies these drugs based on their selectivity and affinity for α and β adrenergic receptors. Examples of non-selective α antagonists discussed include phentolamine, tolazoline, and phenoxybenzamine. Selective α-1 antagonists mentioned are prazosin, terazosin, and doxazosin. Propranolol and atenolol are presented as examples of non-selective and selective β antagonists respectively. The mechanisms of action and properties of several individual drugs are also outlined.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 13

    Subject: Pharmaceutical Chemistry

    Unit 6.2: ADRENERGIC ANTAGONISTS

    Points To Be Cover In This Presentation


     Introduction
     Classification, Properties of Various Drugs Use to Block α and β Receptors.

    PRESENTATION BY: RAVI SHARMA


    QUALIFICATION: M.PHARMACY
    INTRODUCTION
    • Adrenergic antagonist An adrenergic antagonist is a drug that inhibits
    the function of adrenergic receptors.
    • They are competitive antagonists at α or β or both α and β adrenergic
    receptors, and differ in important ways from the “adrenergic neurone
    blocking drugs”, which act by interfering with storage or release of
    adrenergic transmitter.
    • They can be selective or non-selective so they can be classified
    according to their affinity to the receptors.
    CLASSIFICATION
    Phentolamine
    Reversible
    Tolazoline (priscoline)
    Non-selective block α-1 and α-2
    receptor Irreversible Phenoxybenzamine

    Miscellaneous Ergot alkaloids

    Prazosin

    α-Adrenoceptor antagonists
    Terazosin

    α-1 blockers Doxazosin

    Alfuzosin & Bunazosin

    Selective
    Tamsulosin & Silodosin

    Yohimbine
    α-2 blockers
    β-Adrenoceptor antagonists Next Page….. Idazoxam
    MECHANISMS OF ACTION
    Tolazoline
    • Structure:-

    • IUPAC name: 2-benzyl-4,5-dihydro-1H-imidazole


    • Physical Properties: It is a white or creamy white, bitter, crystalline
    powder with slightly aromatic odour. Soluble in water and alcohol,
    and practically insoluble in ether.
    • Storage: Well-closed container.
    • Use: Vasodilator, used to reduce pulmonary artery pressure.
    • Preparation: Tablet and injection
    • Brand name: Priscoline Hydrochloride.
    Phentolamine
    • Structure:-

    • IUPAC name: 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl]-4-


    methylanilino]phenol
    • Physical Properties: It is a white or almost white, crystalline powder.
    Which is slightly hygroscopic. Soluble in water.
    • Storage: Well-closed container, protect from light and moisture.
    • Use: Hypertention.
    • Preparation: Injection
    • Brand name: Regitine and Rogitine.
    Phenoxybenzamine
    • Structure:-

    • IUPAC name: Benzyl(2-chloroethyl)-1-phenoxypropan-2-amine


    • Physical Properties: It is a white or almost white, crystalline powder.
    Springly Soluble in water.
    • Storage: Well-closed container.
    • Use: Antihypertensive Agents, Vasodilator.
    • Preparation: Capsule
    • Brand name: Fenoxene
    Prazosin
    • Structure:-

    • IUPAC name: [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-


    yl]-(furan-2-yl)methanone
    • Physical Properties: It is a white or almost white, crystalline powder,
    slightly Soluble in water.
    • Storage: Well-closed container, protect from light.
    • Use: Antihypertensive Agents, heart failure, benign prostatic hyerplasia.
    • Preparation: Tablet
    • Brand name: Hypovase and minipress
    Propranolol
    • Structure:-

    • IUPAC name: 1-[(1-methylethylamino]-3-(naphthalen-1-yloxy)propan-


    2-ol
    • Physical Properties: It is a white or almost white, crystalline powder,
    Soluble in water.
    • Storage: Well-closed container, protect from moisture.
    • Use: Antihypertensive Agents,
    • Preparation: Tablet, capsule, injection
    • Brand name: Angylol, Inderal, Syprol
    Atenolol
    • Structure:-

    • IUPAC name: 4-(2-Hydroxy-3-


    isopropylaminopropoxy)phenylacetamide
    • Physical Properties: It is a white or almost white, crystalline powder,
    sparingly soluble in water.
    • Storage: Well-closed container, protect from moisture.
    • Use: Antihypertensive Agents,
    • Preparation: Tablet, oral solution, injection
    • Brand name: Aten, Cadres, Hipers, Tenolol
    CARVEDILOL

    I T
    DO L F !
    RS E
    YO U
    You
    ank
    Th

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