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    Osteosarcoma DR: Gehan Mohamed

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    Dimas Bagus
    Osteosarcoma is a malignant bone tumor that develops from primitive bone-forming cells. It most commonly affects adolescents and young adults between 12-25 years old. Risk factors include prior radiation exposure and surviving other cancers like retinoblastoma. Osteosarcoma typically occurs in the long bones of the leg, especially near the knee. Diagnosis involves clinical exams, radiological imaging like x-rays and MRIs, and biopsy of the tumor. Treatment is usually chemotherapy and surgery.

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    Osteosarcoma DR: Gehan Mohamed

    Uploaded by

    Dimas Bagus
    29 views19 pages
    Osteosarcoma is a malignant bone tumor that develops from primitive bone-forming cells. It most commonly affects adolescents and young adults between 12-25 years old. Risk factors include prior radiation exposure and surviving other cancers like retinoblastoma. Osteosarcoma typically occurs in the long bones of the leg, especially near the knee. Diagnosis involves clinical exams, radiological imaging like x-rays and MRIs, and biopsy of the tumor. Treatment is usually chemotherapy and surgery.

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    Osteosarcoma is a malignant bone tumor that develops from primitive bone-forming cells. It most commonly affects adolescents and young adults between 12-25 years old. Risk factors include prior radiation exposure and surviving other cancers like retinoblastoma. Osteosarcoma typically occurs in the long bones of the leg, especially near the knee. Diagnosis involves clinical exams, radiological imaging like x-rays and MRIs, and biopsy of the tumor. Treatment is usually chemotherapy and surgery.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    29 views19 pages

    Osteosarcoma DR: Gehan Mohamed

    Uploaded by

    Dimas Bagus
    Osteosarcoma is a malignant bone tumor that develops from primitive bone-forming cells. It most commonly affects adolescents and young adults between 12-25 years old. Risk factors include prior radiation exposure and surviving other cancers like retinoblastoma. Osteosarcoma typically occurs in the long bones of the leg, especially near the knee. Diagnosis involves clinical exams, radiological imaging like x-rays and MRIs, and biopsy of the tumor. Treatment is usually chemotherapy and surgery.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 19

    Osteosarcoma

    DR: Gehan mohamed

    1
    Osteosarcoma

    03/24/24 2
    Definition

    Osteosarcoma is an aggressive malignant


    neoplasm arising from primitive transformed
    cells of mesenchymal origin (and thus a
    sarcoma) that exhibit osteoblastic
    differentiation and produce malignant osteoid.
    It is the most common histological form of
    primary bone cancer in age 12-25yrs.

    3
    Epidemiology

    Male more than female


    at any age but
    75% of cases appear at age 12-25yrs

    4
    Risk factors:

    Radiation exposure

    Patients who survive after taking therapy for


    another Cancer.

    Retinoblastoma(malignant tumor arising from


    retina of eye).

    5
    Sites of predlection:
    Osteosarcoma :It originates more frequently
    in the metaphyseal region of tubular long
    bones, with 42% occurring in the femur

    6
    Skeletal distribution : most
    common at Knee region

    7
    osteosarcoma

    8
    Histopathologic variants
    1. Conventional: osteoblastic, chondroblastic, fibroblastic
    2. Multifocal
    3. Telangiectatic
    4. Small cell
    5. Intraosseous well-differentiated
    6. Intracortical
    7. Periosteal
    8. Paraosteal
    9. High-grade surface
    10. Extraosseous

    9
    Diagnosis of osteosarcoma
    Clinical examiation
    Radiologic examinatiom
    Biopsy for histopathology

    10
    Clinical Presentation
    Painful mass arising from bone
    Metastasize early

    11
    Plain Xray
    The area of tumor mass may be Lytic,
    sclerotic or mixed

    12
    In x – ray we can see Codman triangle

    Codman triangle is a term used to describe


    the triangular area of new subperiosteal
    bone that is created when a lesion, often a
    tumour, raises the periosteum away from
    the bone.
    sun-burst" appearance on X-ray
    examination due to the tumor spicules of
    calcified bone radiating in right angles

    13
    Codman triangle

    14
    Codman triangle

    15
    Local
    CT

    MRI

    +/- Angiogram

    16
    Systemic
    Bone scan
    CT Chest

    17
    Osteosarcoma :
    it is formed of Spindle shaped cells showing malignant criteria in form
    of pleomorphism,hyperchromasia, abnormal mitosis, giant cells . In
    between spindle cells there is malignant osteoid.

    18
    Differential Dx
    Giant Cell Tumor
    Aneursymal Bone Cyst
    Ewings tumor
    Osteoblastoma
    Metastasis
    Lymphoma

    19

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