Digestive System Pearson

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Digestion

© 2018 Pearson Education, Inc.


The Digestive System Functions

 Ingestion—taking in food
 Digestion—breaking food into nutrient molecules
 Absorption—movement of nutrients into the
bloodstream
 Defecation—excretes to rid the body of
indigestible waste

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Anatomy of the Digestive System

 Two main groups of organs


 Alimentary canal (gastrointestinal, or GI, tract)—
continuous, coiled, hollow tube
 These organs ingest, digest, absorb, defecate
 Accessory digestive organs
 Include teeth, tongue, and several large digestive
organs
 Assist digestion in various ways

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Figure 14.1 The human digestive system: Alimentary canal and accessory organs.

Mouth (oral cavity) Parotid gland


Tongue Sublingual gland Salivary
Submandibular glands
gland

Esophagus Pharynx

Stomach
Pancreas
(Spleen)
Liver
Gallbladder
Transverse colon

Duodenum Descending colon


Small Jejunum
Ascending colon
intestine Ileum
Large
Cecum intestine
Sigmoid colon
Rectum
Appendix
Anus Anal canal
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Organs of the Alimentary Canal

 The alimentary canal is a continuous, coiled,


hollow tube that runs through the ventral cavity
from stomach to anus
 Mouth
 Pharynx
 Esophagus
 Stomach
 Small intestine
 Large intestine
 Anus

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Mouth

 Anatomy of the mouth


 Mouth (oral cavity)—mucous membrane–lined cavity
 Lips (labia)—protect the anterior opening
 Cheeks—form the lateral walls
 Hard palate—forms the anterior roof
 Soft palate—forms the posterior roof
 Uvula—fleshy projection of the soft palate

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Mouth

 Anatomy of the mouth (continued)


 Vestibule—space between lips externally and teeth
and gums internally
 Oral cavity proper—area contained by the teeth
 Tongue—attached at hyoid bone and styloid processes
of the skull, and by the lingual frenulum to the floor of
the mouth

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Mouth

 Anatomy of the mouth (continued)


 Tonsils
 Palatine—located at posterior end of oral cavity
 Lingual—located at the base of the tongue

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Figure 14.2a Anatomy of the mouth (oral cavity).

Nasopharynx
Hard
palate
Soft palate
Oral
cavity
Uvula
Lips (labia) Palatine tonsil
Vestibule Lingual tonsil

Oropharynx
Lingual
frenulum

Epiglottis
Tongue
Laryngopharynx
Hyoid bone
Esophagus
Trachea
(a)
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Figure 14.2b Anatomy of the mouth (oral cavity).

Upper lip
Gingivae
Hard palate (gums)

Soft palate

Uvula

Palatine tonsil

Oropharynx
Tongue
(b)

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Mouth

 Functions of the mouth


 Mastication (chewing) of food
 Tongue mixes masticated food with saliva
 Tongue initiates swallowing
 Taste buds on the tongue allow for taste

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Pharynx

 Serves as a passageway for foods, fluids, and air


 Food passes from the mouth posteriorly into the:
 Oropharynx—posterior to oral cavity
 Laryngopharynx—below the oropharynx and
continuous with the esophagus

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Pharynx

 Food is propelled to the esophagus by two


skeletal muscle layers in the pharynx
 Longitudinal outer layer
 Circular inner layer
 Alternating contractions of the muscle layers
(peristalsis) propel the food

© 2018 Pearson Education, Inc.


Figure 14.2a Anatomy of the mouth (oral cavity).

Nasopharynx
Hard
palate
Soft palate
Oral
cavity
Uvula
Lips (labia) Palatine tonsil
Vestibule Lingual tonsil

Oropharynx
Lingual
frenulum

Epiglottis
Tongue
Laryngopharynx
Hyoid bone
Esophagus
Trachea
(a)
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Esophagus

 Anatomy
 About 10 inches long
 Runs from pharynx to stomach through the diaphragm
 Physiology
 Conducts food by peristalsis (slow rhythmic squeezing)
to the stomach
 Passageway for food only (respiratory system
branches off after the pharynx)

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Layers of Tissue in the Alimentary Canal
Organs
 Summary of the four layers from innermost to
outermost, from esophagus to the large intestine
(detailed next)
1. Mucosa
2. Submucosa
3. Muscularis externa
4. Serosa

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Layers of Tissue in the Alimentary Canal
Organs
1. Mucosa
 Innermost, moist membrane consisting of:
 Surface epithelium that is mostly simple columnar
epithelium (except for esophagus—stratified squamous
epithelium)
 Small amount of connective tissue (lamina propria)
 Scanty smooth muscle layer
 Lines the cavity (known as the lumen)

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Layers of Tissue in the Alimentary Canal
Organs
2. Submucosa
 Just beneath the mucosa
 Soft connective tissue with blood vessels, nerve
endings, mucosa-associated lymphoid tissue, and
lymphatic vessels

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Layers of Tissue in the Alimentary Canal
Organs
3. Muscularis externa—smooth muscle
 Inner circular layer
 Outer longitudinal layer
4. Serosa—outermost layer of the wall; contains
fluid-producing cells
 Visceral peritoneum—innermost layer that is
continuous with the outermost layer
 Parietal peritoneum—outermost layer that lines the
abdominopelvic cavity by way of the mesentery

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Figure 14.3 Basic structure of the alimentary canal wall.

Visceral peritoneum
Intrinsic nerve plexuses
• Myenteric nerve plexus
• Submucosal nerve plexus

Submucosal glands

Mucosa
• Surface epithelium
• Lamina propria
• Muscle layer

Submucosa
Muscularis externa
• Longitudinal
muscle layer
• Circular muscle layer
Serosa
(visceral peritoneum)
Nerve Gland in
Artery Lumen
Mesentery mucosa
Vein Duct of gland Lymphoid tissue
outside alimentary
canal

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Figure 14.5 Peritoneal attachments of the abdominal organs.

Diaphragm
Falciform ligament Lesser
Liver omentum
Spleen
Pancreas
Gallbladder
Stomach Duodenum
Visceral peritoneum Transverse
Greater omentum colon
Mesenteries
Parietal peritoneum

Small intestine Peritoneal


cavity
Uterus

Large intestine
Cecum Rectum
Anus
Urinary bladder

(a) (b)

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Alimentary Canal Nerve Plexuses

 Alimentary canal wall contains two intrinsic nerve


plexuses that are part of the autonomic nervous
system
 Submucosal nerve plexus
 Myenteric nerve plexus
 Regulate mobility and secretory activity of the GI
tract organs

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Stomach

 C-shaped organ located on the left side of the


abdominal cavity
 Food enters at the cardioesophageal sphincter
from the esophagus
 Food empties into the small intestine at the
pyloric sphincter (valve)

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Stomach

 Regions
 Cardial (cardia)—near the heart and surrounds the
cardioesophageal sphincter
 Fundus—expanded portion lateral to the cardiac
region
 Body—midportion
 Greater curvature is the convex lateral surface
 Lesser curvature is the concave medial surface
 Pylorus—funnel-shaped terminal end

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Figure 14.4a Anatomy of the stomach.

Cardia
Fundus

Esophagus

Muscularis
externa Serosa
• Longitudinal layer
• Circular layer
• Oblique layer Body

Lesser Rugae
curvature of
Pylorus
mucosa

Greater
curvature

Duodenum Pyloric Pyloric


sphincter antrum
(a) (valve)
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Figure 14.4b Anatomy of the stomach.

Fundus

Body

Rugae of
mucosa

Pyloric Pyloric
(b) sphincter antrum
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Stomach

 Stomach can stretch and hold 4 L (1 gallon) of


food when full
 Rugae—internal folds of the mucosa present when the
stomach is empty
 Lesser omentum
 Double layer of the peritoneum
 Extends from liver to the lesser curvature of stomach
 Greater omentum
 Another extension of the peritoneum
 Covers the abdominal organs
 Fat insulates, cushions, and protects abdominal organs
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Figure 14.5a Peritoneal attachments of the abdominal organs.

Diaphragm
Falciform ligament
Liver
Spleen
Gallbladder
Stomach

Greater omentum

Small intestine

Large intestine
Cecum

(a)
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Figure 14.5b Peritoneal attachments of the abdominal organs.

Diaphragm
Lesser
Liver omentum

Pancreas

Stomach Duodenum
Visceral peritoneum Transverse
colon
Greater omentum
Mesenteries
Parietal peritoneum

Small intestine Peritoneal


cavity
Uterus

Urinary bladder Rectum


Anus
(b)

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Stomach

 Structure of the stomach mucosa


 Simple columnar epithelium composed almost entirely
of mucous cells
 Mucous cells produce bicarbonate-rich alkaline mucus
 Dotted by gastric pits leading to gastric glands that
secrete gastric juice, including:
 Intrinsic factor, which is needed for vitamin B 12
absorption in the small intestine

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Stomach

 Structure of the stomach mucosa (continued)


 Chief cells—produce protein-digesting enzymes
(pepsinogens)
 Parietal cells—produce hydrochloric acid that activates
enzymes
 Mucous neck cells—produce thin acidic mucus
(different from the mucus produced by mucous cells of
the mucosa)
 Enteroendocrine cells—produce local hormones such
as gastrin

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Stomach

 Functions
 Temporary storage tank for food
 Site of food breakdown
 Chemical breakdown of protein begins
 Delivers chyme (processed food) to the small intestine

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Figure 14.4c Anatomy of the stomach.

Gastric pits

Surface

Gastric pit
epithelium

Pyloric
sphincter
Mucous
neck cells
Gastric gland

Parietal cells

Gastric
glands

Chief cells

(c)
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Figure 14.4d Anatomy of the stomach.

Pepsinogen Pepsin
HCl

Parietal cells

Chief cells

Enteroendocrine
(d) cell

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Small Intestine

 The body’s major digestive organ


 Longest portion of the alimentary tube (2–4 m, or
7–13 feet, in a living person)
 Site of nutrient absorption into the blood
 Muscular tube extending from the pyloric
sphincter to the ileocecal valve
 Suspended from the posterior abdominal wall by
the mesentery

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Figure 14.5 Peritoneal attachments of the abdominal organs.

Diaphragm
Falciform ligament Lesser
Liver omentum
Spleen
Pancreas
Gallbladder
Stomach Duodenum
Visceral peritoneum Transverse
Greater omentum colon
Mesenteries
Parietal peritoneum

Small intestine Peritoneal


cavity
Uterus

Large intestine
Cecum Rectum
Anus
Urinary bladder

(a) (b)

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Small Intestine

 Subdivisions
 Duodenum
 Jejunum
 Ileum

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Small Intestine

 Chemical digestion begins in the small intestine


 Enzymes produced by intestinal cells and pancreas
are carried to the duodenum by pancreatic ducts
 Bile, formed by the liver, enters the duodenum via the
bile duct
 Hepatopancreatic ampulla is the location where the
main pancreatic duct and bile ducts join

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Figure 14.6 The duodenum of the small intestine and related organs.

Right and left


hepatic ducts
from liver

Cystic duct
Common hepatic duct
Bile duct and sphincter
Accessory pancreatic duct

Pancreas
Gallbladder
Jejunum
Duodenal
papilla
Main pancreatic duct and sphincter
Hepatopancreatic
ampulla and sphincter Duodenum
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Small Intestine

 Structural modifications
 Increase surface area for food absorption
 Decrease in number toward the end of the small
intestine
1. Villi—fingerlike projections formed by the mucosa
 House a capillary bed and lacteal
2. Microvilli—tiny projections of the plasma membrane
(brush border enzymes)
3. Circular folds (plicae circulares)—deep folds of
mucosa and submucosa

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Small Intestine

 Peyer’s patches
 Collections of lymphatic tissue
 Located in submucosa
 Increase in number toward the end of the small
intestine
 More are needed there because remaining food
residue contains much bacteria

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Figure 14.7a Structural modifications of the small intestine.

Blood vessels
serving the small
intestine

Lumen
Muscle
layers Circular folds
(plicae circulares)
Villi

(a) Small intestine


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Figure 14.7b Structural modifications of the small intestine.

Absorptive
cells

Lacteal

Villus
Blood
capillaries

Lymphoid
tissue
Intestinal
crypt
Muscularis Venule
mucosae Lymphatic vessel

(b) Villi Submucosa


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Figure 14.7c Structural modifications of the small intestine.

Microvilli
(brush border)

(c) Absorptive
cells

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Large Intestine

 Larger in diameter, but shorter in length at 1.5 m,


than the small intestine
 Extends from the ileocecal valve to the anus
 Subdivisions (detailed next)
 Cecum
 Appendix
 Colon
 Rectum
 Anal canal

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Large Intestine

 Cecum—saclike first part of the large intestine


 Appendix
 Hangs from the cecum
 Accumulation of lymphoid tissue that sometimes
becomes inflamed (appendicitis)

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Large Intestine

 Colon
 Ascending—travels up right side of abdomen and
makes a turn at the right colic (hepatic) flexure
 Transverse—travels across the abdominal cavity and
turns at the left colic (splenic) flexure
 Descending—travels down the left side
 Sigmoid—S-shaped region; enters the pelvis
 Sigmoid colon, rectum, and anal canal are
located in the pelvis

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Large Intestine

 Anal canal ends at the anus


 Anus—opening of the large intestine
 External anal sphincter—formed by skeletal muscle
and is voluntary
 Internal anal sphincter—formed by smooth muscle and
is involuntary
 These sphincters are normally closed except during
defecation
 The large intestine delivers indigestible food
residues to the body’s exterior

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Figure 14.8 The large intestine.

Left colic
(splenic) flexure
Transverse
Right colic mesocolon
(hepatic) flexure

Transverse colon

Haustrum
Descending colon

Ascending colon

Cut edge of
IIeum (cut)
mesentery
IIeocecal valve
Teniae coli

Sigmoid colon
Cecum

Appendix Rectum

Anal canal
External anal sphincter

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Large Intestine

 Goblet cells produce alkaline mucus to lubricate


the passage of feces
 Muscularis externa layer is reduced to three
bands of muscle, called teniae coli
 These bands of muscle cause the wall to pucker
into haustra (pocketlike sacs)

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Accessory Digestive Organs

 Teeth
 Salivary glands
 Pancreas
 Liver
 Gallbladder

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Teeth

 Teeth masticate (chew) food into smaller


fragments
 Humans have two sets of teeth during a lifetime
1. Deciduous (baby or milk) teeth
 A baby has 20 teeth by age 2
 First teeth to appear are the lower central incisors
2. Permanent teeth
 Replace deciduous teeth between ages 6 and 12
 A full set is 32 teeth (with the wisdom teeth)

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Figure 14.9 Deciduous and permanent teeth.
Incisors
Central (6–8 mo)
Lateral (8–10 mo)

Canine (eyetooth)
(16–20 mo)
Molars
First molar
(10–15 mo) Deciduous
Second molar (milk) teeth
(about 2 yr)

Incisors
Central (7 yr)

Lateral (8 yr)

Canine (eyetooth)
(11 yr)
Premolars
(bicuspids)
First premolar
(11 yr)
Second premolar
(12–13 yr)

Molars
First molar (6–7 yr)

Second molar
(12–13 yr)

Third molar
Permanent
(wisdom tooth)
teeth
(17–25 yr)

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Teeth

 Teeth are classified according to shape and


function
 Incisors—cutting
 Canines (eyeteeth)—tearing or piercing
 Premolars (bicuspids)—grinding
 Molars—grinding

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Teeth

 Two major regions of a tooth


1. Crown
2. Root

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Teeth

1. Crown—exposed part of tooth above the


gingiva (gum)
 Enamel—covers the crown
 Dentin—found deep to the enamel and forms the bulk
of the tooth, surrounds the pulp cavity
 Pulp cavity—contains connective tissue, blood
vessels, and nerve fibers (pulp)
 Root canal—where the pulp cavity extends into the
root

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Teeth

2. Root
 Cement—covers outer surface and attaches the tooth
to the periodontal membrane (ligament)
 Periodontal membrane holds tooth in place in the bony
jaw
Note: The neck is a connector between the crown
and root
 Region in contact with the gum

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Figure 14.10 Longitudinal section of a canine tooth.

Enamel
Dentin
Crown
Pulp cavity
(contains blood
vessels and nerves)
Neck
Gum
(gingiva)
Cement

Root canal
Root
Periodontal
membrane
(ligament)

Bone
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Salivary Glands

 Three pairs of salivary glands empty secretions


into the mouth
1. Parotid glands
 Found anterior to the ears
 Mumps affect these salivary glands
2. Submandibular glands
3. Sublingual glands
 Both submandibular and sublingual glands empty saliva
into the floor of the mouth through small ducts

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Figure 14.1 The human digestive system: Alimentary canal and accessory organs.

Mouth (oral cavity) Parotid gland


Tongue Sublingual gland Salivary
Submandibular glands
gland

Esophagus Pharynx

Stomach
Pancreas
(Spleen)
Liver
Gallbladder
Transverse colon

Duodenum Descending colon


Small Jejunum
Ascending colon
intestine Ileum
Large
Cecum intestine
Sigmoid colon
Rectum
Appendix
Anus Anal canal
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Salivary Glands

 Saliva
 Mixture of mucus and serous fluids
 Helps to moisten and bind food together into a mass
called a bolus
 Contains:
 Salivary amylase—begins starch digestion
 Lysozymes and antibodies—inhibit bacteria
 Dissolves chemicals so they can be tasted

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Pancreas

 Soft, pink triangular gland


 Found posterior to the parietal peritoneum
 Mostly retroperitoneal
 Extends across the abdomen from spleen to
duodenum

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Pancreas

 Produces a wide spectrum of digestive enzymes


that break down all categories of food
 Secretes enzymes into the duodenum
 Alkaline fluid introduced with enzymes neutralizes
acidic chyme coming from stomach
 Hormones produced by the pancreas
 Insulin
 Glucagon

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Figure 14.6 The duodenum of the small intestine and related organs.

Right and left


hepatic ducts
from liver

Cystic duct
Common hepatic duct
Bile duct and sphincter
Accessory pancreatic duct

Pancreas
Gallbladder
Jejunum
Duodenal
papilla
Main pancreatic duct and sphincter
Hepatopancreatic
ampulla and sphincter Duodenum
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Liver

 Largest gland in the body


 Located on the right side of the body under the
diaphragm
 Consists of four lobes suspended from the
diaphragm and abdominal wall by the falciform
ligament

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Figure 14.5 Peritoneal attachments of the abdominal organs.

Diaphragm
Falciform ligament Lesser
Liver omentum
Spleen
Pancreas
Gallbladder
Stomach Duodenum
Visceral peritoneum Transverse
Greater omentum colon
Mesenteries
Parietal peritoneum

Small intestine Peritoneal


cavity
Uterus

Large intestine
Cecum Rectum
Anus
Urinary bladder

(a) (b)

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Figure 14.6 The duodenum of the small intestine and related organs.

Right and left


hepatic ducts
from liver

Cystic duct
Common hepatic duct
Bile duct and sphincter
Accessory pancreatic duct

Pancreas
Gallbladder
Jejunum
Duodenal
papilla
Main pancreatic duct and sphincter
Hepatopancreatic
ampulla and sphincter Duodenum
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Liver

 Digestive role is to produce bile


 Bile leaves the liver through the common hepatic duct
and enters duodenum through the bile duct
 Bile is yellow-green, watery solution containing:
 Bile salts and bile pigments (mostly bilirubin from the
breakdown of hemoglobin)
 Cholesterol, phospholipids, and electrolytes
 Bile emulsifies (breaks down) fats

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Gallbladder

 Green sac found in a shallow fossa in the inferior


surface of the liver
 When no digestion is occurring, bile backs up the
cystic duct for storage in the gallbladder
 While in the gallbladder, bile is concentrated by the
removal of water
 When fatty food enters the duodenum, the gallbladder
spurts out stored bile

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Figure 14.6 The duodenum of the small intestine and related organs.

Right and left


hepatic ducts
from liver

Cystic duct
Common hepatic duct
Bile duct and sphincter
Accessory pancreatic duct

Pancreas
Gallbladder
Jejunum
Duodenal
papilla
Main pancreatic duct and sphincter
Hepatopancreatic
ampulla and sphincter Duodenum
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Functions of the Digestive System

 Overview of gastrointestinal processes and


controls
 Digestion
 Absorption
 We will cover six more specific processes next

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Overview of Gastrointestinal Processes and
Controls
 Essential processes of the GI tract
1. Ingestion—placing of food into the mouth
2. Propulsion—movement of foods from one region of
the digestive system to another
 Peristalsis—alternating waves of contraction and
relaxation that squeeze food along the GI tract
 Segmentation—movement of materials back and forth
to foster mixing in the small intestine

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Figure 14.12a Peristaltic and segmental movements of the digestive tract.

(a)
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Functions of the Digestive System

 Essential processes of the GI tract (continued)


3. Food breakdown: mechanical breakdown
 Examples
 Mixing of food in the mouth by the tongue
 Churning of food in the stomach
 Segmentation in the small intestine
 Mechanical digestion prepares food for further
degradation by enzymes

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Figure 14.12b Peristaltic and segmental movements of the digestive tract.

(b)
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Functions of the Digestive System

 Essential processes of the GI tract (continued)


4. Food breakdown: digestion
 Digestion occurs when enzymes chemically break down
large molecules into their building blocks
 Each major food group uses different enzymes
 Carbohydrates are broken down to monosaccharides
(simple sugars)
 Proteins are broken down to amino acids
 Fats are broken down to fatty acids and glycerol

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Figure 14.13 Flowchart of digestion and absorption of foodstuffs (1 of 3).

Foodstuff Enzyme(s) and source Site of action

Starch and disaccharides


Digestion of Salivary amylase Mouth
carbohydrates
Pancreatic amylase Small intestine
Oligosaccharides*
and disaccharides

Brush border enzymes Small intestine


Lactose Maltose Sucrose in small intestine
(dextrinase,
glucoamylase,
lactase, maltase,
Galactose Glucose Fructose and sucrase)

The monosaccharides glucose, galactose, and fructose


Absorption of
enter the capillary blood in the villi and are transported to
carbohydrates
the liver via the hepatic portal vein.

*Oligosaccharides consist of a few linked monosaccharides.

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Figure 14.13 Flowchart of digestion and absorption of foodstuffs (2 of 3).

Foodstuff Enzyme(s) and source Site of action

Protein
Digestion
of proteins Pepsin (stomach glands) Stomach
in the presence of HCl
Large polypeptides

Pancreatic enzymes Small intestine


(trypsin, chymotrypsin,
Small polypeptides carboxypeptidase)

Brush border enzymes Small intestine


(aminopeptidase,
Amino acids carboxypeptidase,
(some dipeptides and dipeptidase)
and tripeptides)

Absorption Amino acids enter the capillary blood in the villi and are
of proteins transported to the liver via the hepatic portal vein.

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Figure 14.13 Flowchart of digestion and absorption of foodstuffs (3 of 3).

Foodstuff Enzyme(s) and source Site of action

Unemulsified fats
Digestion
of fats Emulsified by the Small intestine
detergent action
of bile salts from the liver

Pancreatic lipase Small intestine

Monoglycerides Glycerol and


and fatty acids fatty acids

Fatty acids and monoglycerides enter the lacteals of the villi


Absorption and are transported to the systemic circulation via the lymph
of fats in the thoracic duct. (Glycerol and short-chain fatty acids are
absorbed into the capillary blood in the villi and transported
to the liver via the hepatic portal vein.)

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Functions of the Digestive System

 Essential processes of the GI tract (continued)


5. Absorption
 End products of digestion are absorbed in the blood or
lymph
 Food must enter mucosal cells and then move into
blood or lymph capillaries
6. Defecation
 Elimination of indigestible substances from the GI tract
in the form of feces

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Figure 14.11 Schematic summary of gastrointestinal tract activities.

Ingestion
Food
Mechanical
breakdown Pharynx

• Chewing (mouth) Esophagus


• Churning (stomach) Propulsion
• Segmentation • Swallowing
(small intestine) (oropharynx)
• Peristalsis
Digestion
(esophagus,
stomach,
small intestine,
large intestine)
Stomach

Absorption
Lymph
vessel

Small
intestine
Blood
Large
vessel
intestine
Mainly H2O
Feces

Anus
Defecation

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Activities Occurring in the Mouth, Pharynx,
and Esophagus
 Food ingestion and breakdown
 Food is placed into the mouth
 Physically broken down by chewing
 Mixed with saliva, which is released in response to
mechanical pressure and psychic stimuli
 Salivary amylase begins starch digestion
 Essentially, no food absorption occurs in the mouth

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Activities Occurring in the Mouth, Pharynx,
and Esophagus
 Food propulsion—swallowing and peristalsis
 Pharynx and esophagus have no digestive function
 Serve as passageways to the stomach
 Pharynx functions in swallowing (deglutition)
 Two phases of swallowing
1. Buccal phase
2. Pharyngeal-esophageal phase

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Activities Occurring in the Mouth, Pharynx,
and Esophagus
 Food propulsion—swallowing and peristalsis
(continued)
1. Buccal phase
 Voluntary
 Occurs in the mouth
 Food is formed into a bolus
 The bolus is forced into the pharynx by the tongue

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Activities Occurring in the Mouth, Pharynx,
and Esophagus
 Food propulsion—swallowing and peristalsis
(continued)
2. Pharyngeal-esophageal phase
 Involuntary transport of the bolus by peristalsis
 Nasal and respiratory passageways are blocked

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Activities Occurring in the Mouth, Pharynx,
and Esophagus
 Food propulsion—swallowing and peristalsis
(continued)
2. Pharyngeal-esophogeal phase (continued)
 Peristalsis moves the bolus toward the stomach
 The cardioesophageal sphincter is opened when food
presses against it

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Figure 14.14 Swallowing (1 of 4).

Bolus of food

Tongue

Pharynx
Epiglottis
up Upper
esophageal
Glottis (lumen) sphincter
of larynx

Trachea Esophagus

1 Upper esophageal
sphincter contracted

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Figure 14.14 Swallowing (2 of 4).

Uvula
Bolus
Epiglottis
down

Larynx up
Esophagus
2 Upper esophageal
sphincter relaxed

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Figure 14.14 Swallowing (3 of 4).

Bolus

3 Upper esophageal
sphincter contracted

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Figure 14.14 Swallowing (4 of 4).

Relaxed
muscles
Cardioesophageal
sphincter open

4 Cardioesophageal
sphincter relaxed

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Activities in the Stomach

 Food breakdown
 Gastric juice is regulated by neural and hormonal
factors
 Presence of food or rising pH causes the release of
the hormone gastrin
 Gastrin causes stomach glands to produce:
 Protein-digesting enzymes
 Mucus
 Hydrochloric acid

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Activities in the Stomach

 Food breakdown (continued)


 Hydrochloric acid makes the stomach contents very
acidic
 Acidic pH
 Activates pepsinogen to pepsin for protein digestion
 Provides a hostile environment for microorganisms

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Activities in the Stomach

 Food breakdown (continued)


 Protein-digestion enzymes
 Pepsin—an active protein-digesting enzyme
 Rennin—works on digesting milk protein in infants; not
produced in adults
 Alcohol and aspirin are virtually the only items
absorbed in the stomach

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Activities in the Stomach

 Food propulsion
1. Peristalsis: waves of peristalsis occur from the
fundus to the pylorus, forcing food past the pyloric
sphincter
2. Grinding: the pylorus meters out chyme into the
small intestine (3 ml at a time)
3. Retropulsion: peristaltic waves close the pyloric
sphincter, forcing contents back into the stomach; the
stomach empties in 4–6 hours

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Figure 14.15 Peristaltic waves in the stomach.

Pyloric Pyloric Pyloric


valve valve valve
closed slightly closed
opened

1 Propulsion: Peristaltic 2 Grinding: The most 3 Retropulsion: The


waves move from the fundus vigorous peristalsis and peristaltic wave closes the
toward the pylorus. mixing action occur close pyloric valve, forcing most of
to the pylorus. The pyloric the contents of the pylorus
end of the stomach acts as backward into the stomach.
a pump that delivers small
amounts of chyme into the
duodenum.

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Activities of the Small Intestine

 Chyme breakdown and absorption


 Intestinal enzymes from the brush border function to:
 Break double sugars into simple sugars
 Complete some protein digestion
 Intestinal enzymes and pancreatic enzymes help to
complete digestion of all food groups

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Activities of the Small Intestine

 Chyme breakdown and absorption (continued)


 Pancreatic enzymes play the major role in the
digestion of fats, proteins, and carbohydrates
 Alkaline content neutralizes acidic chyme and provides
the proper environment for the pancreatic enzymes to
operate

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Activities of the Small Intestine

 Chyme breakdown and absorption (continued)


 Release of pancreatic juice from the pancreas into the
duodenum is stimulated by:
 Vagus nerves
 Local hormones that travel via the blood to influence the
release of pancreatic juice (and bile)
 Secretin
 Cholecystokinin (CCK)

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Activities of the Small Intestine

 Chyme breakdown and absorption (continued)


 Hormones (secretin and CCK) also target the liver and
gallbladder to release bile
 Bile
 Acts as a fat emulsifier
 Needed for fat absorption and absorption of fat-soluble
vitamins (K, D, E, and A)

© 2018 Pearson Education, Inc.


Figure 14.16 Regulation of pancreatic juice and bile secretion and release.

4 Secretin
causes the liver to
secrete more bile;
CCK stimulates
the gallbladder
1 Chyme entering to release stored
duodenum causes bile and the
duodenalent hepatopancreatic
eroendocrine cells to sphincter to relax
release cholecystokinin (allows bile from
(CCK) and secretin. both sources to
enter the
duodenum).
2 CCK (red dots) and
secretin (blue dots)
5 Stimulation
enter the bloodstream. by vagal nerve
fibers causes
3 Upon reaching the release of
pancreas, CCK induces pancreatic juice
secretion of enzyme- and weak
rich pancreatic juice; contractions of
secretin causes the gallbladder.
secretion of bicarbonate-
rich pancreatic juice.

© 2018 Pearson Education, Inc.


Activities of the Small Intestine

 Chyme breakdown and absorption (continued)


 A summary table of hormones is presented next

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Table 14.1 Hormones and Hormonelike Products That Act in Digestion (1 of 2)

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Table 14.1 Hormones and Hormonelike Products That Act in Digestion (2 of 2)

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Activities of the Small Intestine

 Chyme breakdown and absorption (continued)


 Water is absorbed along the length of the small
intestine
 End products of digestion
 Most substances are absorbed by active transport
through cell membranes
 Lipids are absorbed by diffusion
 Substances are transported to the liver by the hepatic
portal vein or lymph

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Activities of the Small Intestine

 Chyme propulsion
 Peristalsis is the major means of moving food
 Segmental movements
 Mix chyme with digestive juices
 Aid in propelling food

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Figure 14.12 Peristaltic and segmental movements of the digestive tract.

(a)

(b)
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Activities of the Large Intestine

 Nutrient breakdown and absorption


 No digestive enzymes are produced
 Resident bacteria digest remaining nutrients
 Produce some vitamin K and some B vitamins
 Release gases
 Water, vitamins, ions, and remaining water are
absorbed
 Remaining materials are eliminated via feces

© 2018 Pearson Education, Inc.


Activities of the Large Intestine

 Nutrient breakdown and absorption (continued)


 Feces contains:
 Undigested food residues
 Mucus
 Bacteria
 Water

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Activities of the Large Intestine

 Propulsion of food residue and defecation


 Sluggish peristalsis begins when food residue arrives
 Haustral contractions are the movements occurring
most frequently in the large intestine
 Mass movements are slow, powerful movements that
occur three to four times per day

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Activities of the Large Intestine

 Propulsion of food residue and defecation


(continued)
 Presence of feces in the rectum causes a defecation
reflex
 Internal anal sphincter is relaxed
 Defecation occurs with relaxation of the voluntary
(external) anal sphincter

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Part II: Nutrition and Metabolism

 Most foods are used as metabolic fuel


 Foods are oxidized and transformed into adenosine
triphosphate (ATP)
 ATP is chemical energy that drives cellular activities
 Energy value of food is measured in kilocalories
(kcal) or Calories (C)

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Nutrition

 Nutrient—substance used by the body for growth,


maintenance, and repair
 Major nutrients
 Carbohydrates
 Lipids
 Proteins
 Water
 Minor nutrients
 Vitamins
 Minerals

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Nutrition

 A diet consisting of foods from the five food


groups normally guarantees adequate amounts of
all the needed nutrients
 The five food groups are summarized next in
Table 14.2

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Table 14.2 Five Basic Food Groups and Some of Their Major Nutrients (1 of 2)

© 2018 Pearson Education, Inc.


Table 14.2 Five Basic Food Groups and Some of Their Major Nutrients (2 of 2)

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Dietary Recommendations

 Healthy Eating Pyramid


 Issued in 1992
 Six major food groups arranged horizontally
 MyPlate
 Issued in 2011 by the USDA
 Five food groups are arranged by a round plate

© 2018 Pearson Education, Inc.


Figure 14.17 Two visual food guides.

Red meat, butter: White rice, white bread,


use sparingly potatoes, pasta, sweets:
use sparingly
Dairy or calcium
supplement: 1–2 servings
Fish, poultry, eggs:
0–2 servings
Nuts, legumes:
1–3 servings
Vegetables Fruits:
in abundance 2–3 servings
Whole-grain Plant oils
foods at at most
most meals
Daily excercise and weight control
meals

(a) Healthy Eating Pyramid

(b) USDA’s MyPlate


© 2018 Pearson Education, Inc.
Dietary Sources of the Major Nutrients

 Carbohydrates
 Dietary carbohydrates are sugars and starches
 Most are derived from plants such as fruits and
vegetables
 Exceptions: lactose from milk and small amounts of
glycogens from meats

© 2018 Pearson Education, Inc.


Dietary Sources of the Major Nutrients

 Lipids
 Saturated fats from animal products (meats)
 Unsaturated fats from nuts, seeds, and vegetable oils
 Cholesterol from egg yolk, meats, and milk products
(dairy products)

© 2018 Pearson Education, Inc.


Dietary Sources of the Major Nutrients

 Proteins
 Complete proteins—contain all essential amino acids
 Most are from animal products (eggs, milk, meat,
poultry, and fish)
 Essential amino acids: those that the body cannot make
and must be obtained through diet
 Legumes and beans also have proteins, but the
proteins are incomplete

© 2018 Pearson Education, Inc.


Figure 14.18 The eight essential amino acids.

Tryptophan Beans
and other
Methionine legumes
Valine
Threonine
Phenylalanine
Leucine
Corn and Isoleucine
other grains
Lysine

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Dietary Sources of the Major Nutrients

 Vitamins
 Most vitamins function as coenzymes
 Found mainly in fruits and vegetables

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Dietary Sources of the Major Nutrients

 Minerals
 Mainly important for enzyme activity
 Foods richest in minerals: vegetables, legumes, milk,
and some meats

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Metabolism

 Metabolism is all of the chemical reactions


necessary to maintain life
 Catabolism—substances are broken down to simpler
substances; energy is released and captured to make
adenosine triphosphate (ATP)
 Anabolism—larger molecules are built from smaller
ones

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Carbohydrate Metabolism

 Carbohydrates are the body’s preferred source to


produce cellular energy (ATP)
 Glucose (blood sugar)
 Major breakdown product of carbohydrate digestion
 Fuel used to make ATP

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Carbohydrate Metabolism

 Cellular respiration
 As glucose is oxidized, carbon dioxide, water, and ATP
are formed

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Figure 14.19 Summary equation for cellular respiration.

C6H12O6 6 O2 6 CO2 6 H2O ATP

Glucose Oxygen Carbon Water Energy


gas dioxide

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Carbohydrate Metabolism

 Events of three main metabolic pathways of


cellular respiration
1. Glycolysis
 Occurs in the cytosol
 Energizes a glucose molecule so it can be split into two
pyruvic acid molecules and yield ATP

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Carbohydrate Metabolism

 Events of three main metabolic pathways of


cellular respiration (continued)
2. Citric acid cycle (Krebs cycle)
 Occurs in the mitochondrion
 Produces virtually all the carbon dioxide and water
resulting from cellular respiration
 Yields a small amount of ATP

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Carbohydrate Metabolism

 Events of three main metabolic pathways of


cellular respiration (continued)
3. Electron transport chain
 Hydrogen atoms removed during glycolysis and the
citric acid cycle are delivered to protein carriers
 Hydrogen atoms are split into hydrogen ions and
electrons in the mitochondria
 Electrons give off energy in a series of steps to enable
the production of ATP

© 2018 Pearson Education, Inc.


Figure 14.20 The formation of ATP in the cytosol and the mitochondria during cellular respiration.

Chemical energy (high-energy electrons)

CO2 Chemical energy

CO2
Electron transport
Glycolysis chain and oxidative
Citric
phosphorylation
Glucose
Pyruvic acid H2O
acid cycle

Cytosol Mitochondrion
Mitochondrial
of cell Via oxidative
cristae
phosphorylation
Via substrate-level
phosphorylation

2 2 28
ATP ATP ATP

1 During glycolysis, each 2 The pyruvic acid enters 3 Energy-rich electrons picked up by
glucose molecule is broken the mitochondrion, where coenzymes are transferred to the electron
down into two molecules of citric acid cycle enzymes transport chain, built into the cristae
pyruvic acid as hydrogen remove more hydrogen membrane. The electron transport chain
atoms containing high- atoms and decompose it to carries out oxidative phosphorylation, which
energy electrons are CO2. During glycolysis and accounts for most of the ATP generated by
removed. the citric acid cycle, small cellular respiration, and finally unites the
amounts of ATP are formed. removed hydrogen with oxygen to form
water.
© 2018 Pearson Education, Inc.
Figure 14.21 Energy release in the electron transport chain versus one-step reduction of oxygen.

NADH NAD+ + H+ Energy released as heat and light


E ne
rg
avai y relea
2e– lable se
for m d and n
akin ow
g AT
P

of th Prot
e el ec ei n ca r
tron ri
tran ers
spo
r t ch
ai n e–
Electron
flow
O2

(a) (b)

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Carbohydrate Metabolism

 Hyperglycemia—excessively high levels of


glucose in the blood
 Excess glucose is stored in body cells as glycogen or
converted to fat
 Hypoglycemia—low levels of glucose in the blood
 Glycogenolysis, gluconeogenesis, and fat breakdown
occur to restore normal blood glucose levels

© 2018 Pearson Education, Inc.


Figure 14.22a Metabolism by body cells.

(a) Carbohydrates: polysaccharides, disaccharides;


composed of simple sugars (monosaccharides)
ATP
Glycogen and fat
Polysaccharides broken down for
Cellular uses
ATP formation
GI digestion to
simple sugars To Excess stored as
capillary glycogen or fat
Broken down to glucose
Monosaccharides and released to blood

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Fat Metabolism

 Fats
 Insulate the body
 Protect organs
 Build some cell structures (membranes and myelin
sheaths)
 Provide reserve energy
 Excess dietary fat is stored in subcutaneous
tissue and other fat depots

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Fat Metabolism

 When carbohydrates are in limited supply, more


fats are oxidized to produce ATP
 Excessive fat breakdown causes blood to become
acidic (acidosis or ketoacidosis)
 Breath has a fruity odor
 Common with:
 “No carbohydrate” diets
 Uncontrolled diabetes mellitus
 Starvation

© 2018 Pearson Education, Inc.


Figure 14.22b Metabolism by body cells.

(b) Fats: composed of 1 glycerol


molecule and 3 fatty acids;
triglycerides Cellular ATP Fats are the
Metabolized uses primary fuels
Lipid (fat)
Fatty by liver to in many cells
acids GI digestion acetic acid, etc.
to fatty acids
and glycerol Insulation and fat Fats build myelin
cushions to protect sheaths and cell
body organs membranes

Glycerol

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Protein Metabolism

 Proteins form the bulk of cell structure and most


functional molecules
 Proteins are carefully conserved by body cells
 Amino acids are actively taken up from blood by
body cells

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Protein Metabolism

 Amino acids are oxidized to form ATP mainly


when other fuel sources are not available
 Ammonia, released as amino acids are
catabolized, is detoxified by liver cells that
combine it with carbon dioxide to form urea

© 2018 Pearson Education, Inc.


Figure 14.22c Metabolism by body cells.

(c) Proteins: polymers of amino acids


ATP formation if inadequate
ATP glucose and fats or if essential
Protein Normally amino acids are lacking
infrequent
Functional proteins
GI digestion to (enzymes, antibodies,
amino acids Cellular hemoglobin, etc.)
uses
Structural proteins
Amino (connective tissue fibers,
acids muscle proteins, etc.)

© 2018 Pearson Education, Inc.


Figure 14.22d Metabolism by body cells.

(d) ATP formation (fueling the metabolic


furnace): all categories of food can be
oxidized to provide energy molecules (ATP) Carbon
dioxide
Cellular
Monosaccharides metabolic “furnace”: Water
Citric acid cycle
Fatty acids and
electron transport
Amino acids chain
(amine first removed ATP
and combined with
CO2 by the liver to form urea)

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The Central Role of the Liver in Metabolism

 Liver is the body’s key metabolic organ


 Roles in digestion
 Manufactures bile
 Detoxifies drugs and alcohol
 Degrades hormones
 Produces cholesterol, blood proteins (albumin and
clotting proteins)
 Plays a central role in metabolism
 Liver can regenerate if part of it is damaged or
removed

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The Central Role of the Liver in Metabolism

 To maintain homeostasis of blood glucose levels,


the liver performs:
 Glycogenesis—“glycogen formation”
 Glucose molecules are converted to glycogen and
stored in the liver
 Glycogenolysis—“glycogen splitting”
 Glucose is released from the liver after conversion from
glycogen
 Gluconeogenesis—“formation of new sugar”
 Glucose is produced from fats and proteins

© 2018 Pearson Education, Inc.


Figure 14.23 Metabolic events occurring in the liver as the blood glucose level rises and falls.
Glycogenesis:
Glucose converted to
glycogen and stored

IM
BA
Stimulus: ANL
Rising blood CE
glucose level HOMEOSTATIC BLOOD SUGAR

Stimulus:
IM
BA Falling blood
L AN
CE glucose level
Glycogenolysis:
Stored glycogen
converted to glucose

Gluconeogenesis:
Amino acids and fats
converted to glucose
© 2018 Pearson Education, Inc.
The Central Role of the Liver in Metabolism

 Fats and fatty acids are picked up by the liver


 Some are oxidized to provide energy for liver cells
 The rest are either stored or broken down into simpler
compounds and released into the blood

© 2018 Pearson Education, Inc.


The Central Role of the Liver in Metabolism

 Blood proteins made by the liver are assembled


from amino acids
 Albumin is the most abundant protein in blood
 Clotting proteins
 Liver cells detoxify ammonia
 Ammonia is combined with carbon dioxide to form
urea, which is flushed from the body in urine

© 2018 Pearson Education, Inc.


The Central Role of the Liver in Metabolism

 Cholesterol metabolism and transport


 Cholesterol is not used to make ATP
 Functions of cholesterol:
 Structural basis of steroid hormones and vitamin D
 Building block of plasma membranes
 Most cholesterol (85%) is produced in the liver; only
15% is from the diet

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The Central Role of the Liver in Metabolism

 Cholesterol metabolism and transport (continued)


 Cholesterol and fatty acids cannot freely circulate in
the bloodstream
 They are transported by lipoproteins (lipid-protein
complexes) known as LDLs and HDLs

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The Central Role of the Liver in Metabolism

 Cholesterol metabolism and transport (continued)


 Low-density lipoproteins (LDLs) transport cholesterol
to body cells
 Rated “bad lipoproteins” since they can lead to
atherosclerosis
 High-density lipoproteins (HDLs) transport cholesterol
from body cells to the liver
 Rated “good lipoproteins” since cholesterol is destined
for breakdown and elimination

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Body Energy Balance

 Energy intake = Total energy output


(heat + work + energy storage)
 Energy intake is the energy liberated during food
oxidation
 Energy produced during glycolysis, citric acid cycle, and
the electron transport chain
 Energy output
 Energy we lose as heat (60%)
 Energy stored as fat or glycogen

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Body Energy Balance

 Interference with the body’s energy balance leads


to:
 Obesity
 Malnutrition (leading to body wasting)

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Body Energy Balance

 Regulation of food intake


 Body weight is usually relatively stable
 Energy intake and output remain about equal
 Mechanisms that may regulate food intake
 Levels of nutrients in the blood
 Hormones
 Body temperature
 Psychological factors

© 2018 Pearson Education, Inc.


Body Energy Balance

 Metabolic rate and body heat production


 Nutrients yield different amounts of energy
 Energy value is measured in kilocalories (kcal)
 Carbohydrates and proteins yield 4 kcal/gram
 Fats yield 9 kcal/gram

© 2018 Pearson Education, Inc.


Body Energy Balance

 Basic metabolic rate (BMR)—amount of heat


produced by the body per unit of time at rest
 Average BMR is about 60 to 72 kcal/hour for an
average 70-kg (154-lb) adult

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Body Energy Balance

 Factors that influence BMR


 Surface area—a small body usually has a higher BMR
 Gender—males tend to have higher BMRs
 Age—children and adolescents have higher BMRs
 The amount of thyroxine produced is the most
important control factor
 More thyroxine means a higher metabolic rate

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Table 14.3 Factors Determining the Basal Metabolic Rate (BMR)

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Body Energy Balance

 Total metabolic rate (TMR)—total amount of


kilocalories the body must consume to fuel
ongoing activities
 TMR increases dramatically with an increase in
muscle activity
 TMR must equal calories consumed to maintain
homeostasis and maintain a constant weight

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Body Energy Balance

 Body temperature regulation


 When foods are oxidized, more than 60% of energy
escapes as heat, warming the body
 The body has a narrow range of homeostatic
temperature
 Must remain between 35.6ºC and 37.8ºC
 (96ºF and 100ºF)

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Body Energy Balance

 Body temperature regulation


 The body’s thermostat is in the hypothalamus
 Hypothalamus initiates mechanisms to maintain body
temperature
 Heat loss mechanisms involve radiation of heat from
skin and evaporation of sweat
 Heat-promoting mechanisms involve vasoconstriction of
skin blood vessels and shivering

© 2018 Pearson Education, Inc.


Figure 14.24 Mechanisms of body temperature regulation.
Skin blood vessels dilate:
Capillaries become flushed
with warm blood; heat
radiates from skin surface

Activates
heat loss center
in hypothalamus
Sweat glands are activated: Body temperature
Secrete perspiration, which decreases: Blood
Blood warmer is vaporized by body heat, temperature
than hypothalamic helping to cool the body declines, and
set point hypothalamus
heat-loss center
“shuts off”
Stimulus:
IM
Increased body BA
LA
temperature NC
(e.g., when E
exercising or the HOMEOSTASIS = NORMAL BODY
climate is hot) TEMPERATURE (35.6ºC–37.8ºC)
Stimulus:
Decreased body
temperature
IM (e.g., due to cold
BA
LA environmental
NC
E temperatures)

Skin blood vessels constrict:


Blood cooler than
Blood is diverted from skin
capillaries and withdrawn to hypothalamic set
Body temperature deeper tissues; minimizes point
increases: Blood overall heat loss from
temperature rises, skin surface
and hypothalamus
heat-promoting
center “shuts off”
Activates heat-
promoting center
in hypothalamus
Skeletal muscles
are activated when more
heat must be generated;
shivering begins
© 2018 Pearson Education, Inc.
Figure 14.24 Mechanisms of body temperature regulation. Slide 1

Skin blood vessels dilate:


Capillaries become flushed
with warm blood; heat
radiates from skin surface

Activates
heat loss center
in hypothalamus
Sweat glands are activated: Body temperature
Secrete perspiration, which decreases: Blood
Blood warmer is vaporized by body heat, temperature
than hypothalamic helping to cool the body declines, and
set point hypothalamus
heat-loss center
“shuts off”
Stimulus:
IM
Increased body BA
temperature LA
NC
(e.g., when E
exercising or the HOMEOSTASIS = NORMAL BODY
climate is hot) TEMPERATURE (35.6ºC–37.8ºC)

IM
BA
LA
NC
E
© 2018 Pearson Education, Inc.
Figure 14.24 Mechanisms of body temperature regulation. Slide 2

Stimulus:
IM
Increased body BA
temperature LA
NC
(e.g., when E
exercising or the HOMEOSTASIS = NORMAL BODY
climate is hot) TEMPERATURE (35.6ºC–37.8ºC)

IM
BA
LA
NC
E
© 2018 Pearson Education, Inc.
Figure 14.24 Mechanisms of body temperature regulation. Slide 3

Activates
heat loss center
in hypothalamus

Blood warmer
than hypothalamic
set point

Stimulus:
IM
Increased body BA
temperature LA
NC
(e.g., when E
exercising or the HOMEOSTASIS = NORMAL BODY
climate is hot) TEMPERATURE (35.6ºC–37.8ºC)

IM
BA
LA
NC
E
© 2018 Pearson Education, Inc.
Figure 14.24 Mechanisms of body temperature regulation. Slide 4

Skin blood vessels dilate:


Capillaries become flushed
with warm blood; heat
radiates from skin surface

Activates
heat loss center
in hypothalamus
Sweat glands are activated:
Secrete perspiration, which
Blood warmer is vaporized by body heat,
than hypothalamic helping to cool the body
set point

Stimulus:
IM
Increased body BA
temperature LA
NC
(e.g., when E
exercising or the HOMEOSTASIS = NORMAL BODY
climate is hot) TEMPERATURE (35.6ºC–37.8ºC)

IM
BA
LA
NC
E
© 2018 Pearson Education, Inc.
Figure 14.24 Mechanisms of body temperature regulation. Slide 5

Skin blood vessels dilate:


Capillaries become flushed
with warm blood; heat
radiates from skin surface

Activates
heat loss center
in hypothalamus
Sweat glands are activated: Body temperature
Secrete perspiration, which decreases: Blood
Blood warmer is vaporized by body heat, temperature
than hypothalamic helping to cool the body declines, and
set point hypothalamus
heat-loss center
“shuts off”
Stimulus:
IM
Increased body BA
temperature LA
NC
(e.g., when E
exercising or the HOMEOSTASIS = NORMAL BODY
climate is hot) TEMPERATURE (35.6ºC–37.8ºC)

IM
BA
LA
NC
E
© 2018 Pearson Education, Inc.
Figure 14.24 Mechanisms of body temperature regulation. Slide 6

Skin blood vessels dilate:


Capillaries become flushed
with warm blood; heat
radiates from skin surface

Activates
heat loss center
in hypothalamus
Sweat glands are activated: Body temperature
Secrete perspiration, which decreases: Blood
Blood warmer is vaporized by body heat, temperature
than hypothalamic helping to cool the body declines, and
set point hypothalamus
heat-loss center
“shuts off”
Stimulus:
IM
Increased body BA
temperature LA
NC
(e.g., when E
exercising or the HOMEOSTASIS = NORMAL BODY
climate is hot) TEMPERATURE (35.6ºC–37.8ºC)

IM
BA
LA
NC
E
© 2018 Pearson Education, Inc.
Figure 14.24 Mechanisms of body temperature regulation. Slide 7
IM
BA
LA
NC
E
HOMEOSTASIS = NORMAL BODY
TEMPERATURE (35.6ºC–37.8ºC)
Stimulus:
Decreased body
temperature
IM
BA (e.g., due to cold
LA
NC environmental
E temperatures)

© 2018 Pearson Education, Inc.


Figure 14.24 Mechanisms of body temperature regulation. Slide 8
IM
BA
LA
NC
E
HOMEOSTASIS = NORMAL BODY
TEMPERATURE (35.6ºC–37.8ºC)
Stimulus:
Decreased body
temperature
IM
BA (e.g., due to cold
LA
NC environmental
E temperatures)

Blood cooler than


hypothalamic set
point

Activates heat-
promoting center
in hypothalamus

© 2018 Pearson Education, Inc.


Figure 14.24 Mechanisms of body temperature regulation. Slide 9
IM
BA
LA
NC
E
HOMEOSTASIS = NORMAL BODY
TEMPERATURE (35.6ºC–37.8ºC)
Stimulus:
Decreased body
temperature
IM
BA (e.g., due to cold
LA
NC environmental
E temperatures)
Skin blood vessels constrict: Blood cooler than
Blood is diverted from skin hypothalamic set
capillaries and withdrawn to point
deeper tissues; minimizes
overall heat loss from
skin surface

Activates heat-
promoting center
in hypothalamus
Skeletal muscles
are activated when more
heat must be generated;
shivering begins
© 2018 Pearson Education, Inc.
Figure 14.24 Mechanisms of body temperature regulation. Slide 10
IM
BA
LA
NC
E
HOMEOSTASIS = NORMAL BODY
TEMPERATURE (35.6ºC–37.8ºC)
Stimulus:
Decreased body
temperature
IM
BA (e.g., due to cold
LA
NC environmental
E temperatures)
Skin blood vessels constrict: Blood cooler than
Blood is diverted from skin hypothalamic set
capillaries and withdrawn to point
Body temperature deeper tissues; minimizes
increases: Blood overall heat loss from
temperature rises, skin surface
and hypothalamus
heat-promoting
center “shuts off”
Activates heat-
promoting center
in hypothalamus
Skeletal muscles
are activated when more
heat must be generated;
shivering begins
© 2018 Pearson Education, Inc.
Figure 14.24 Mechanisms of body temperature regulation. Slide 11
IM
BA
LA
NC
E
HOMEOSTASIS = NORMAL BODY
TEMPERATURE (35.6ºC–37.8ºC)
Stimulus:
Decreased body
temperature
IM
BA (e.g., due to cold
LA
NC environmental
E temperatures)
Skin blood vessels constrict: Blood cooler than
Blood is diverted from skin hypothalamic set
capillaries and withdrawn to point
Body temperature deeper tissues; minimizes
increases: Blood overall heat loss from
temperature rises, skin surface
and hypothalamus
heat-promoting
center “shuts off”
Activates heat-
promoting center
in hypothalamus
Skeletal muscles
are activated when more
heat must be generated;
shivering begins
© 2018 Pearson Education, Inc.
Body Energy Balance

 Fever—controlled hyperthermia
 Results from infection, cancer, allergic reactions, CNS
injuries
 If the body thermostat is set too high, body proteins
may be denatured, and permanent brain damage may
occur

© 2018 Pearson Education, Inc.


Part III: Developmental Aspects of the
Digestive System and Metabolism
 The alimentary canal is a continuous, hollow tube
present by the fifth week of development
 Digestive glands bud from the mucosa of the
alimentary tube
 The developing fetus receives all nutrients
through the placenta
 In newborns, feeding must be frequent, peristalsis
is inefficient, and vomiting is common

© 2018 Pearson Education, Inc.


Developmental Aspects of the Digestive
System and Metabolism
 Newborn reflexes
 Rooting reflex helps the infant find the nipple
 Sucking reflex helps the infant hold on to the nipple
and swallow
 Teething begins around age 6 months

© 2018 Pearson Education, Inc.


Developmental Aspects of the Digestive
System and Metabolism
 Problems of the digestive system
 Gastroenteritis—inflammation of the gastrointestinal
tract; can occur at any time
 Appendicitis—inflammation of the appendix; common
in adolescents
 Metabolism decreases with old age
 Middle-age digestive problems
 Ulcers
 Gallbladder problems

© 2018 Pearson Education, Inc.


Developmental Aspects of the Digestive
System and Metabolism
 Later middle-age problems
 Obesity
 Diabetes mellitus
 Activity of the digestive tract in old age
 Fewer digestive juices
 Peristalsis slows
 Diverticulosis and gastrointestinal cancers are more
common

© 2018 Pearson Education, Inc.

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