Y2020 PBL Case Neurology System 150622

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PBL Y2020

Administration

• Patient’s full name: Tran T. Bich L., female, 32-year-old


• Address: Chau Doc – An Giang province
• Occupation: kindergarten teacher (at a local school)
• Reason of admission: headache
History of present illness
• Two weeks history of a continuous headache.
History of present illness
• Holocranial headache was the sole complaint for the past 2 weeks.
• The patient presented with a gradual onset of headache, from VAS score of 2/10 to
VAS score of round 6-8/10 at admission.
• She had sporadic menorrhagia with recent heavy menstrual bleeding during her
last cycle (3 weeks ago) 
• The patient’s hematology tests were consistent with iron deficiency anemia. She
was subsequently transfused with 3 units of packed red blood cells and discharged
after 2 days when hemoglobin returned to 11.2g/dL.
• However, she returned to the hospital one day later due to a worsening headache
and vomiting.
• In the course of the disease, the patient had no fever, no aura, no blurring vision,
no convulsion.
Past history

Individual:
???

Family:
???
Past history

Individual:
• There are no history of cardiovascular disease, coagulopathy, no prior
history of migraines, chronic/recurrent headaches or recent head trauma.
• Daily using oral contraceptives.

Family: no disease-related records


Clinical examination???
Clinical examination

• Her vital signs showed a temperature of 37.0°C, blood pressure of 130/80 


mmHg, pulse 85 bpm and oxygen saturation of 97% on air.
• She was conscious and oriented.
• Her neck was soft. Neurologic examination presented intact reflexes,
motor and sensory functions, no evidence of cranial nerve involvement but
the ophthalmoscopy found papilledema.
• On full examination no other external signs of disease.
Solutions

• Diagnostic hypothesis ?
• Differential Diagnosis ?
• Investigations ?
Investigations

• Blood counting
• Na+, K+, Cl- , AST, ALT, uremia, Creatinemia
• ECG, Chest X-ray, abdominal echography
• Fundoscopy
• Brain CT-scan/MRI
• (Cerebrospinal fluid microscopy ???)
Relevant blood test results
• Glycemia 105 mg/dL
• WBC 6,73 K/uL, N 78,0%, Lympho 7,1%, Mono 8,2%, Eos 0,6%
Hgb 11,9 g/dL, Hct 35,7%, MCV 83,7fL, MCH 28pg, MCHC 33,9 g/dL.
PLT 220 K/uL
• Na+ 128 mmol/l, K+ 3,22 mmol/l
• Creatinemia 55 µmol/l, Uremia 4,8 mmol/L
• AST/ALT 22/23 UI/L
CSF results

• CSF appearance clear


• CFS microscopy: WCC: 78/mm3 (N 16%; M 84%, E 0%)
• CFS protein 5,1 g/L; CFS glucose 3,8 mmol/L (glycemia 6,7);
Lactate 2,9 mmol/L
• CFS culture: no bacterial growth
• India ink stain: no detect
• Acid-fast bacillus stain: negative
Diagnosis?

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