Diarrhea
Diarrhea
Diarrhea
A brief update
What is diarrhea?
• Diarrhea is defined as the passage of loose,
liquid or watery stools, usually more than 3
times/day.
• However it is the recent change in consistency
and character of stools that is more important.
• The term ‘diarrheal diseases’ should be
considered as a convenient expression only, and
not as a nosological or epidemiological entity.
What is diarrhea?
• Diarrhea is best defined as excessive loss of fluid
and electrolyte in the stool.
• Acute diarrhea is defined as sudden onset of
excessively loose stools of >10 mL/kg/day in
infants and >200 g/24 hr in older children,
which lasts <14 days.
• When the episode lasts longer than 14 days, it
is called chronic or persistent diarrhea.
• Dysentery is small-volume, frequent bloody
stools with mucus, tenesmus, and urgency.
Types of diarrheal diseases
• Acute watery diarrhea
– Main danger dehydration and weight loss if prolonged
• Acute bloody diarrhea (dysentery)
– Main dangers are damage of intestinal mucosa, sepsis,
malnutrition, dehydration
• Persistent diarrhea
– Main danger is malnutrition
• Diarrhea with severe malnutrition (marasmus and
kwashiorkor)
– Main dangers are severe systemic infection, dehydration,
heart failure, vitamin and mineral deficiencies
Mechanisms of diarrhea
• Secretory
– Decreased absorption, increased secretion,
electrolyte transport
– Watery, normal osmolality with ion gap <100
mOsm/kg
– Cholera, toxigenic Escherichia coli ; carcinoid, VIP,
neuroblastoma, congenital chloride diarrhea,
Clostridium difficile , cryptosporidiosis (AIDS)
– Persists during fasting
Mechanisms of diarrhea
• Osmotic
– Maldigestion, transport defects, ingestion of
unabsorbable substances
– Watery, acidic, and reducing substances; increased
osmolality with ion gap >100 mOsm/kg
– Lactase deficiency, glucose galactose
malabsorption, lactulose, laxative abuse
– Stops with fasting
Mechanisms of diarrhea
• Increased motility
– Decreased transit time
– Loose to normal appearing stool, stimulated by
gastrocolic reflex
– Irritable bowel syndrome, thyrotoxicosis,
postvagotomy dumping syndrome
– Infection can also contribute to increased motility
Mechanisms of diarrhea
• Decreased motility
– Pseudoobstruction, blind loop
– Possible bacterial overgrowth
– Loose to normal appearing stool
• Decreased surface area (osmotic,motility)
– Decreased functional capacity
– Short bowel syndrome
• Mucosal invasion
– Inflammation, decreased colonic reabsorption, increased
motility
– Blood, increased WBC in stool
– Shigella, Salmonella, Yersinia, Campylobacter
Plan A: Treat diarrhoea at home
Start IV fluid immediately. If the child can drink, give ORS by mouth while the drip is set up.
Give 100ml/kg Ringer’s Lactate Solution (or, if not available, normal saline), divided as
follows:
Note:
• If possible, observe the child at least 6 hours after rehydration to be sure the mother can
maintain hydration giving the child ORS solution by mouth.