Diarrhea

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Diarrhea

A brief update
What is diarrhea?
• Diarrhea is defined as the passage of loose,
liquid or watery stools, usually more than 3
times/day.
• However it is the recent change in consistency
and character of stools that is more important.
• The term ‘diarrheal diseases’ should be
considered as a convenient expression only, and
not as a nosological or epidemiological entity.
What is diarrhea?
• Diarrhea is best defined as excessive loss of fluid
and electrolyte in the stool.
• Acute diarrhea is defined as sudden onset of
excessively loose stools of >10 mL/kg/day in
infants and >200 g/24 hr in older children,
which lasts <14 days.
• When the episode lasts longer than 14 days, it
is called chronic or persistent diarrhea.
• Dysentery is small-volume, frequent bloody
stools with mucus, tenesmus, and urgency.
Types of diarrheal diseases
• Acute watery diarrhea
– Main danger dehydration and weight loss if prolonged
• Acute bloody diarrhea (dysentery)
– Main dangers are damage of intestinal mucosa, sepsis,
malnutrition, dehydration
• Persistent diarrhea
– Main danger is malnutrition
• Diarrhea with severe malnutrition (marasmus and
kwashiorkor)
– Main dangers are severe systemic infection, dehydration,
heart failure, vitamin and mineral deficiencies
Mechanisms of diarrhea
• Secretory
– Decreased absorption, increased secretion,
electrolyte transport
– Watery, normal osmolality with ion gap <100
mOsm/kg
– Cholera, toxigenic Escherichia coli ; carcinoid, VIP,
neuroblastoma, congenital chloride diarrhea,
Clostridium difficile , cryptosporidiosis (AIDS)
– Persists during fasting
Mechanisms of diarrhea
• Osmotic
– Maldigestion, transport defects, ingestion of
unabsorbable substances
– Watery, acidic, and reducing substances; increased
osmolality with ion gap >100 mOsm/kg
– Lactase deficiency, glucose galactose
malabsorption, lactulose, laxative abuse
– Stops with fasting
Mechanisms of diarrhea
• Increased motility
– Decreased transit time
– Loose to normal appearing stool, stimulated by
gastrocolic reflex
– Irritable bowel syndrome, thyrotoxicosis,
postvagotomy dumping syndrome
– Infection can also contribute to increased motility
Mechanisms of diarrhea
• Decreased motility
– Pseudoobstruction, blind loop
– Possible bacterial overgrowth
– Loose to normal appearing stool
• Decreased surface area (osmotic,motility)
– Decreased functional capacity
– Short bowel syndrome
• Mucosal invasion
– Inflammation, decreased colonic reabsorption, increased
motility
– Blood, increased WBC in stool
– Shigella, Salmonella, Yersinia, Campylobacter
Plan A: Treat diarrhoea at home

• Treat a child who has diarrhoea and NO DEHYDRATION


with Plan A. The 3 Rules of Home Treatment are:
• 1. GIVE EXTRA FLUID (as much as the child will take)
2. CONTINUE FEEDING
3. WHEN TO RETURN
• Children with diarrhea who come to a health facility
with NO DEHYDRATION will be put on Plan A. Children
with SOME or SEVERE dehydration need to be
rehydrated on Plan B or C, and then put on Plan A.
Eventually, all children with diarrhea will be on Plan A.
Plan A: Treat diarrhoea at home
• RULE 1: GIVE EXTRA FLUID
• Tell the mother or caretaker:
• Give as much fluid as the child will take. The purpose of giving extra fluid is to
replace the fluid lost in diarrhoea and thus to prevent dehydration. The critical
action is to give more fluid than usual, as soon as the diarrhoea starts.
• Tell the mother to breastfeed frequently and for longer at each feed. Also
explain that she should give other fluids. ORS solution is one of several fluids
recommended for home use to prevent dehydration.
• If the child is exclusively breastfed, it is important for this child to be breastfed
more frequently than usual. Also give ORS solution or clean water. Breastfed
children under 4 months should first be offered a breastfeed then given ORS.
• If a child is not exclusively breastfed, give one or more of the following:
• - ORS solution
- Food-based fluids
- Clean waterIn most cases a child who is not dehydrated does not really need
ORS solution. Give him extra food-based fluids such as soups, rice water and
yoghurt drinks, and clean water (preferably given along with food).
Plan A: Treat diarrhoea at home
• Show the mother or caretaker how much fluid to give in addition to the usual
fluid intake
• Explain to the mother that her child should drink the usual fluids that the child
drinks each day and extra fluid. Show the mother how much extra fluid to give
after each loose stool:
•  Up to 2 years 50 to 100 ml after each loose stool
•  2 years or more 100 to 200 ml after each loose stool
• Explain to the mother that the diarrhoea should stop soon. ORS solution will not
stop diarrhoea. The benefit of ORS solution is that it replaces the fluid and salts
that the child loses in the diarrhoea and prevents the child from getting sicker.
• Tell the mother to:
• Give frequent small sips from a cup or spoon. Use a spoon to give fluid to a young
child.
• If the child vomits, wait 10 minutes before giving more fluid. Then resume giving
the fluid, but more slowly.
• Continue giving extra fluid until the diarrhoea stops.
Plan A: Treat diarrhoea at home
• RULE 2: CONTINUE FEEDING
• If a child is classified with PERSISTENT DIARRHOEA, we will teach
the mother some special feeding recommendations.
• RULE 3: WHEN TO RETURN
• Tell the mother of any sick child that the signs to return are:
• • Not able to drink or breastfeed
• Becomes sicker
• Develops a fever
• If the child has diarrhoea, also tell the mother to return if the
child has:
• Blood in stool
• Drinking poorly “Drinking poorly” includes “not able to drink or
breastfeed.”
Plan B: Treat some dehydration with ORS
• Determine the amount of ORS to give during the first 4 hours
• The age or weight of the child, the degree of dehydration and the number of
stools passed during rehydration will all affect the amount of ORS solution
needed. The child will usually want to drink as much as he needs. If the child
wants more or less than the estimated amount, give him what he wants.
• Multiply the child’s weight (in kilograms) by 75. For example, a child weighing
8 kg would need: 8 kg × 75 ml = 600 ml of ORS solution in 4 hours
• Giving ORS solution should not interfere with a breastfed baby’s normal
feeding. The mother should pause to let the baby breastfeed whenever the
baby wants to, then resume the ORS solution.
• For infants under 6 months who are not breastfed, the mother should give
100-200 ml clean water during the first 4 hours in addition to the ORS
solution. The breastmilk and water will help prevent hypernatraemia in
infants.
Plan B: Treat some dehydration with ORS
•After 4 hours
–After 4 hours of treatment on Plan B, reassess the child using the ASSESS
AND CLASSIFY chart.
•Note: Reassess the child before 4 hours if the child is not taking the ORS
solution or seems to be getting worse.
•If the child has improved and has NO DEHYDRATION, choose Plan A.
•Note: If the child’s eyes are puffy, it is a sign of overhydration. It is not a
danger sign or a sign of hypernatraemia. It is simply a sign that the child
has been rehydrated and does not need any more ORS solution at this
time. The child should be given clean water or breastmilk. The mother
should give ORS solution according to Plan A when the puffiness is gone.
•If the child still has SOME DEHYDRATION, choose Plan B again.
•If the child is worse and now has SEVERE DEHYDRATION, you will need
to begin Plan C.
Plan C - Treat severe dehydration quickly

 Start IV fluid immediately. If the child can drink, give ORS by mouth while the drip is set up.
Give 100ml/kg Ringer’s Lactate Solution (or, if not available, normal saline), divided as
follows:

AGE First give 30 ml/kg in: Then give 70 ml/kg in:


Infants 1 hour* 5 hours
(under 12 months)
Children 30 minutes* 2 ½ hours
(12 months up to 5 years)
* Repeat once if radial pulse is still very weak or not detectable.• Reassess the child every 1-
2 hours. If hydration status is not improving, give the IV drip more rapidly.
• Also give ORS (about 5 ml/kg/hour) as soon as the child can drink: usually after 3-4 hours
(infants) or 1-2 hours (children).
• Reassess an infant after 6 hours and a child after 3 hours. Classify dehydration. Then
choose the appropriate plan (A,B, or C) to continue treatment.

Note:
• If possible, observe the child at least 6 hours after rehydration to be sure the mother can
maintain hydration giving the child ORS solution by mouth.

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