DNA and Genetics
Prepared By: Ms. Jerelyn Buenafe
What do you
think?
Before you read, decide if you
agree or disagree with each of these
statements.
Any condition present at birth
is genetic.
A change in the sequence of an
organism’s DNA always
changes the organism’s trait.
Learning Targets
At the end of the lesson
you should be able to:
Differentiate DNA
and RNA
Identify the four
nucleotides of DNA
Differentiate the
types of mutations
The Structure of DNA
DNA (deoxyribonucleic
acid)
This chemical substance is present in the nucleus
of all cells in all living organisms
controls all the chemical changes which take
place in cells
is a very large molecule made up of a long chain
of sub-units (NUCLEOTIDES)
Each nucleotide is made up
of :
• a sugar called deoxyribose
• a phosphate group -PO4 and
• an organic base
Ribose is a sugar, like glucose, but with only
five carbon atoms in its molecule
Deoxyribose is almost the same but lacks one
oxygen atom
Both molecules may be represented by the
symbol
A complex molecule
DNA is like a twisted zipper-
double helix
Rosalind Franklin and Maurice
Wilkins- used X-rays to study DNA
James Watson and Francis Crick-
build a model of DNA
Erwin Chargaff- discovered
chemical information about DNA
Four Nucleotides Shape DNA
The deoxyribose, the phosphate and one of the bases
Combine to form a nucleotide
PO4
adenine
deoxyribose
5
The bases
The most common organic bases are
Adenine (A)
Thymine (T)
Cytosine (C)
Guanine (G)
Joined nucleotides 7
PO4
A molecule of DNA is
PO4 formed by millions of
nucleotides joined
together in a long
PO4
chain
PO4
sugar-phosphate
+ bases
backbone
Bonding 1 10
The bases always pair up in the same way
Adenine forms a bond with Thymine
Adenine Thymine
and Cytosine bonds with Guanine
Cytosine Guanine
Pairing up 12
PO4
PO4
PO4
PO4
PO4 PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
REPLICATION
• The process of copying a DNA molecule to
make another DNA molecule
• • Each chain of nucleotides serves as a
template for a new, complimentary,
strand
• • Helicase – the enzyme complex that
separates nucleotide chains of DNA
• • The point of separation is called the
replication fork
• • DNA polymerase – enzyme that allows
complimentary nucleotides to build the
complimentary chains
• • 5 prime to 3 prime direction
• • Replication runs in opposite directions
16
STEPS OF replication
• Before a cell divides, the DNA strands unwind and separate
• Each strand makes a new partner by adding the appropriate nucleotides
• The result is that there are now two double-stranded DNA molecules
in the nucleus
• So that when the cell divides, each nucleus contains identical DNA
Making Proteins
JUNK DNA
• Segments of DNA
that are not parts of
genes
The Role of RNA in
Making Proteins
• RNA- type of nucleic acid
that carries the code for
making proteins for the
nucleus to the cytoplasm
• Carries amino acids
around inside a cell and
forms a part of ribosomes
• Has Uracil (U) instead of
Thymine (T)
Three Types of RNA
• mRNA (messenger RNA)
-carries the code (A,U,C,G) in three letter sequences called
codons
-Codons: code for individual amino acids, starts, or stops
• tRNA(transfer RNA)
-are RNA molecules that translate mRNA into protein
• rRNA (ribosomal RNA)
-forms ribosomes, which are essential in protein
synthesis
Mutations
A change in the nucleotide
sequence of a gene
Types of Mutation
• SUBSTITUTION
• INSERTION
• DELETION
• DUPLICATION
Results of Mutation
• Depends on where in the DNA
sequence the mutation happened and
the type of mutation
• Proteins express traits and change in
proteins causes traits to change
