LC-2010CHT

HIGH THROUGH-PUT HPLC

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 PRODUCT OVERVIEW
Fast injection System integrity
　－ 15 sec / 10 uL injection 　－ Pre-inspected system performance
High sample capacity Automatic Validation
　－ 350 samples （ 1mL), MTP ： 4 　－ Modules and system

SIL

Oven

Pump UV
Automatic operation Intelligent LC analyzer
　－ Automatic system preparation 　－ Method transfer with FD
Timer
2 operation Simple maintenance
　－ Automatic warm-up/ shutdown 　－ All front access
 DESIGN OVERVIEW
Auto injector Others
　－ 350 （ 1mL), 210(1.5mL), 100(4mL) 　－ Column management device
　－ 100uL (std), Max. 2mL (op) 　－ FD in MS-DOS format
　－ Automatic rack recognition 　　

Pump UV detector
　－ Built-in active inlet valve (AIV) 　－ Cell with temperature control
　－3Automatic drain 　－ Automatic cell recognition
　－ Automatic seal wash 　－ Built-in Hg lamp for validation
PRINCIPAL SOLVENT DELIVERY UNIT SPECIFICATIONS

・ Serial Double Plunger System

　　－ Primary 10L, Secondary 5L
・ Low Pressure Gradient System
　　－ No. of solvents: 4
　　－ Mixture Ratio Settings: 0 to100%, 0.1%
increments
　　－ Concentration Accuracy: within +/- 0.5%
　　－ Concentration Precision: within +/- 0.1%
・ Flow Rate Range: 0.001 to 5mL/min
・ Flow Rate Accuracy: within +/- 1%
・ Flow Rate Precision: 0.075%RSD
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Solvent Delivery Unit Features (2)

・ Auto Purge does not require the drain valve

to be opened and closed
　　　→ Straight to equilibrium from purging
・ The degasser is standard equipment
・ Equipped as standard with a seal rinsing
flow line (improved durability)

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　 LC-2010 CONCEPT ：～ HAVE ～
H : High Throughput
•High Speed Injection
– 15 seconds (when injecting 10L)
•Multiple Sample Processing
– 350x Samples (1mL vial)
– 4x Microtiter Plates

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　 LC-2010 CONCEPT ：～ H AVE ～
A : Automation
•Automated Analytical Operation
– Auto Start Up
–Auto Purge
–Auto Baseline Check
–Auto Shutdown

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　 LC-2010 CONCEPT ：～ HA VE ～

V : Validation
•Auto Validation
•Guarantee of system performance
•Column Management Device

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　 LC-2010 CONCEPT ：～ HAV E

E : Ease of Use
•Graphical Operation System
–GUI Capability
–Wizard Function
•Front access for maintenance

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SOLVENT DELIVERY UNIT FEATURES

－ Dynamic Inlet Check Valve

－ Short Stroke Serial Double Plunger

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PRINCIPAL DETECTOR SPECIFICATIONS
・ Light Source: Deuterium lamp
・ Wavelength Range: 190 to 600nm
・ Spectral Bandwidth: 8 nm
・ Wavelength Accuracy: below +/- 1 nm
・ Wavelength Reproducibility:
below +/- 0.1 nm
・ Cell Optical Path: 10 mm
・ Cell Volume: 8L
・ Drift: below 1×10-4AU/hr (250 nm ， air in cell ）
・ Noise Level: below +/- 0.25 x10-5AU （ as above ）
・ Cell Temperature Control System: 3 switching steps - OFF,
High, & Low
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 DETECTOR FEATURES
・ Adoption of a temperature controlled cell unit
　　　－ Maximizes the reproducibility of quantitative values
・ Built-in validation device (upgraded validation)
　　　－ Built-in mercury lamp to check wavelength accuracy
　　　－ Built-in filter to check absorbance accuracy
・ Automatic cell recognition
capability

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EFFECT OF THE TEMPERATURE CONTROLLED CELL
The temperature controlled cell unit maximizes stability
・ It eliminates variations in the quantitative value due to thermal expansion
of the mobile phase or temperature fluctuations in the sample spectrum.
Quantitative values are kept constant irrespective of the measurement time
(morning / evening) or season (summer / winter). 　→ Reproducibility of
quantitative values
・ Stable analysis even in the short wavelength region where there are large
variations in the absorption spectrum 　
　 Shortening of stabilization times 　　→ Improved productivity 　
Spectrum at low temperature

Spectrum at high temperature

Difference in absorbance due

to temperature changes

Measurement Wavelength
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PRINCIPAL AUTOSAMPLER SPECIFICATIONS

・ Injection System: Total sample injection

・ Injection Range: 0.1 to 100L(standard)
　　　　　　　　　 1 to 2000L(option)
・ Repeatability of Injection Amount:
below 0.3%RSD(10L)
・ Injection Amount Accuracy:
within +/- 1% (50l ， n=6)
・ Cross-contamination: below 0.01%(naphthalene)
・ Sample Cooler*: 4 to 40deg. C(built-in dehumidifier)
・ No. of Samples: 350 x 1mL vials
　　　　　　　　 210 x 1.5mL vials (140 vials*)
　　　　　　　　 100 x 4mL vials
　　　　　　　　 4x Micro titer Plates

14 ＊ with sample cooler attached (LC-2010CHT)

 AUTOSAMPLER FEATURES

・ Configured for multiple samples

　　　－ 350x samples (1mL vials) ， 4x MTPs (maximum 1536 samples)
・ High Speed Injection
　　　－ 15sec （ when injecting 10L)
・ Trace Amount Injection
　　　－ Injection amounts can be
set from 0.1L upwards
・ Automatic Recognition of Rack Type
　　　－ Prevents operational errors
・ Equipped as standard with a
dehumidifier (LC-2010CHT)

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PRINCIPAL COLUMN OVEN SPECIFICATIONS
・ Block heating system (with preheating)
・ Temperature Settings Range: 4 to 60deg. C (1deg. C step)
・ Temperature Control Range:
(room temperature‐15deg. C) to 60deg. C
・ Temperature Control Precision: +/- 0.1deg. C
・ Size within oven: 2x 250 mm columns

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VALIDATION SUPPORT (1)
Auto Validation
　－ The advantages of an all-in-one system are put to effective use
　－ Fully automatic
　－ Approximately 1.5 hours with the Isocratic mode
　－ Approximately 3 hours even if the Gradient Check is included

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 VALIDATION SUPPORT (2)

･ Performance Check
　－ Validation support through the Wizard
･ System Check
　－ Validation report
･ IQ/OQ documents are attached as standard

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SUMMARY

LC-2010CHT
HAVE
• Configured for High Throughput (H)
• Automation (A)
• Validation (V)
• Ease of Use (E)
Improved Basic Performance
• Dynamic Inlet Valve
• Temperature controlled cell unit

- High throughput Auto-sampler

• 15 sec injection Speed
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• Near zero carry over