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    Apex 1 (Autosaved)

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    Nikul Rathod
    The document provides details about an internship report submitted by Nikulsinh Rathod for their Chemical Engineering internship at Apex Healthcare Limited in February 2023. It includes an introduction to the company, descriptions of raw materials and products including piroxicam, major equipment and instrumentation used, the process flow diagram, unit operations, and a project on designing a shell and tube heat exchanger.

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    Apex 1 (Autosaved)

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    Nikul Rathod
    13 views14 pages
    The document provides details about an internship report submitted by Nikulsinh Rathod for their Chemical Engineering internship at Apex Healthcare Limited in February 2023. It includes an introduction to the company, descriptions of raw materials and products including piroxicam, major equipment and instrumentation used, the process flow diagram, unit operations, and a project on designing a shell and tube heat exchanger.

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    The document provides details about an internship report submitted by Nikulsinh Rathod for their Chemical Engineering internship at Apex Healthcare Limited in February 2023. It includes an introduction to the company, descriptions of raw materials and products including piroxicam, major equipment and instrumentation used, the process flow diagram, unit operations, and a project on designing a shell and tube heat exchanger.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    13 views14 pages

    Apex 1 (Autosaved)

    Uploaded by

    Nikul Rathod
    The document provides details about an internship report submitted by Nikulsinh Rathod for their Chemical Engineering internship at Apex Healthcare Limited in February 2023. It includes an introduction to the company, descriptions of raw materials and products including piroxicam, major equipment and instrumentation used, the process flow diagram, unit operations, and a project on designing a shell and tube heat exchanger.

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    © All Rights Reserved
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    Download as pptx, pdf, or txt
    of 14

    TRAINING INTENSHIP REPORT

    FEBRUARY 2023

    CHEMICAL ENGINEERING
    DEPARTMENT
    NAME:- RATHOD NIKULSINH
    ENROLLMENT NO:- 19SE02CH029
    CONTENT

    1. INTRODUCTION TO COMPANY
    2. RAW MATERIALS AND PRODUCT
    3. MAJOR EQUIPMENTS AND INSTRUMENTATION
    4. PROCESS USE OF APEX HEALTHCARE LIMITED
    5. MAJOR UNIT OPERATION IN APEX HEALTHCARE LIMITED
    6. Project work
    1.Introduction To Shree Ganesh Remedies

     Apex Healthcare Limited is one of the most reputed and reliable manufacturer &exporter of pharma API & Intermediates in and
    out of India.

     Apex Healthcare Limited has been a leading manufacturer of Pharmaceutical products since 2002 with the sole vision of
    providing affordable medicines for the masses.

     The director of the organization, envisions Apex healthcare to emerge as an innovative and cost-effective player of API that
    is driven by advanced technology across the globe. His primary goal is to grow the company while cutting down the release
    of toxins and pollutantsin the environment.
     In 2003 The birth of a dream Mr. Ramesh Gabani & Mr. Umesh Mendapara initiated this journey with the name Apex
    Laboratory Ltd. In 2007 re-named the firm Apex Healthcare Ltd, which is a Public limited company. In 2009 Honorable Dr.
    Chandu Gabani was appointed as a Director and played a vital role in the growth & vision of the organization.It has
    pursued a strategy of continuous expansion, product Branding, research & development, thrust on aggressive market.
    2.Raw Material And Product

    Dimethylformamide Molecular weight : 146.19  About BCP


    (DMF) Melting point : −61°C
    Boiling point : 153°C  Dimethylformamide is an organic compound
    Molecular weight : 206.18
    with the formula (CH3)2NC(O)H. Commonly
    Sodium saccharin
    Melting point : >300°C abbreviated as DMF (although this initialism is
    Boiling point : 438.9°C
    sometimes used for dimethylfuran, or
    Methylene dichloride Molecular weight : 84.93 dimethyl fumarate), this colourless liquid is
    Melting point :−96.7°C miscible with water and the majority of
    Boiling point : 39.6°C
    organic liquids. DMF is a common solvent for
    Dimethylsulfide Molecular weight : 62.14
    chemical reactions.
    Melting point : 19°C
    Boiling point : 189°C

    IPA Molecular weight : 40


    Melting point : 323 °C
    Boiling point : 1388 °C
    Methanol Molecular weight : 32.04
    Melting point : : -97.6 °C
    Boiling point : : 64.7 °C
    Prouduct and its properties

     PIROXICAME  Piroxieam is a non-steroidal anti-inflammatory


    drug, of the oxieam class. A contact and
    Synonym Felden, Dexicam, pyroxycam, photocontact sensitizer, which induced
    Roxicame
    contact dermatitis in a physieal therapist.
    IUPAC No 4-hydroxy-2-methyl-1 Piroxieam generally cross reacts with
    thiosalicylic acid and also with thiomersal.
    CAS No 36322-90-4 Cross sensitivity is not observed to
    tenoxicam.
    API Adiphenine Hydrochloride

    Chemical Structure

    Chemical Formula C15H13N3O4S


    Molecular Weight 331.35

    Product Stage Commercial


    Other Products

     Alendronate Sodium
     Bisacodyl
     Sodium Picosulphate
     Meloxicam
     Lornoxicam
     Lidocaine
     Benzocaine
     Lidocaine
     Lidocaine Hydrochloride
     Prilocaine
    Production Capacity

    Pyroxicam : 650kg/ 7 day

    Phenoramedol : 420kg/ 6 day

    Meloxicam : 440kg/ 6 day

    Bisacodyl : 110kg/ 4 day

    Thiozole : 450kg/ 4 day

    Methyl ester : 470kg/ 3 day

     Annual Turnover : Approx. INR 600 million

     Exports : More than 50 Countries


    3.Major Equipment And Instrumentation

    Pipe line Colour

    Cooling water inlet Sea Green

    Cooling Water outlet Green

    Chilling water inlet Silver Insulation sea green + black

    Chilling water outlet Sea Green + Black + canary yellow

    Hot Oil inlet Light brown

    Hot Oil outlet Light brown + canary yellow

    Stream Blue

    Fire Red
    3.Major Equipment And Instrumentation

     Glass line Reactor

    Types of vessel
    Closed type Jacketed
    vessel having glass
    lining inside

    Shell Capacity 3400 litre

    Volumetric Capacity 3000 litre

    Stirrer Anchor type

    Diameter 1500 mm
    Length 1700 mm
    3.Major Equipment and Instrumentation

    1. Stainless Steel Reactor


    2. Heat Exchanger
    3. Centrifuge
    4. Fluid Bed Dryer
    5. Rotocone Vaccume Dryer
    6. Sparkler filter
    7. Milling
    8. Sifter
    4.PROCESS FLOW DIAGRAM
    5. MAJOR UNIT OPERATION FLOW DIAGRAM IN APEX
    HEALTHCARE LIMITED

    Crude
    Reaction filtration Purification Filtration

    pulverization Drying Pure Filtration Crystallization

    Sifter Final product


    PROJECT :- Design of shell and tube
    heathexchanger

     The main parts of a shell and tube heat exchanger include:

    1. Shell

    2. Tube

    3. Baffles

    4. Tie rods

    5. Tube sheet
    Design Steps :-

    1. Define the duty : heat transfer rate, fluid flow rates, and temperature.

    2. Collect all the fluid physical properties regarding density, viscosity, thermal conductivity, specific heat etc.
    3. Calculate the mean temperature difference (Tm)

    4. Selecta trial value of the overall coefficient of heat transfer, U

    5. Calculate the area required for heat transfer from the equation Q=U A∆Tm

    6. Calculate the individual film coefficient.

    7. Calculate the overall coefficient and compare with the trial value. If the calculated value differs significantly from the estimated value, substitute the
    calculated valuefortheestimatedvalueandreturntostep5.

    8. Calculate the pressure drops, if un-satisfactory return to step 6 or 4 in that order of preference.

    9. Optimize the design; repeat step 4-10 as necessary to determine the cheapest condenser that will satisfy the duty within the allowable pressure drop.
    Usually this will be the one with the smallest area.

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