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    Paget Disease

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    Francesco Mazzarella
    Paget's disease is a metabolic bone disease that involves an accelerated rate of bone remodeling, weakening the skeleton and increasing risk of fractures. It occurs when osteoclasts that break down bone and osteoblasts that build new bone are imbalanced. Remodeling takes place too quickly, resulting in abnormal bone formation. Paget's disease usually affects one or a few bones like the spine, femur or tibia. While there is no cure, drugs can help control symptoms like bone pain and reduce risks of complications. The causes are unknown but may involve genetic or viral factors.

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    Paget Disease

    Uploaded by

    Francesco Mazzarella
    32 views11 pages
    Paget's disease is a metabolic bone disease that involves an accelerated rate of bone remodeling, weakening the skeleton and increasing risk of fractures. It occurs when osteoclasts that break down bone and osteoblasts that build new bone are imbalanced. Remodeling takes place too quickly, resulting in abnormal bone formation. Paget's disease usually affects one or a few bones like the spine, femur or tibia. While there is no cure, drugs can help control symptoms like bone pain and reduce risks of complications. The causes are unknown but may involve genetic or viral factors.

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    Paget's disease is a metabolic bone disease that involves an accelerated rate of bone remodeling, weakening the skeleton and increasing risk of fractures. It occurs when osteoclasts that break down bone and osteoblasts that build new bone are imbalanced. Remodeling takes place too quickly, resulting in abnormal bone formation. Paget's disease usually affects one or a few bones like the spine, femur or tibia. While there is no cure, drugs can help control symptoms like bone pain and reduce risks of complications. The causes are unknown but may involve genetic or viral factors.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    32 views11 pages

    Paget Disease

    Uploaded by

    Francesco Mazzarella
    Paget's disease is a metabolic bone disease that involves an accelerated rate of bone remodeling, weakening the skeleton and increasing risk of fractures. It occurs when osteoclasts that break down bone and osteoblasts that build new bone are imbalanced. Remodeling takes place too quickly, resulting in abnormal bone formation. Paget's disease usually affects one or a few bones like the spine, femur or tibia. While there is no cure, drugs can help control symptoms like bone pain and reduce risks of complications. The causes are unknown but may involve genetic or viral factors.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 11

    PAGET BONE DISEASE

    INTRODUCTION

    Metabolic disease of the bone known as “deforming


    osteocitis” or “Paget bone disease”, this pathology
    involves an alteration of the bone remodeling the
    process of destruction and regrowth of the bone, which
    occurs at an accelerated rate, undermining the
    structural integrity of the skeleton making the bone
    weaker and predisposing to fractures and bone
    malformations
    Remodelling takes place by two cell:

    Osteoblast: Osteoclasts:
    Responsible for the bone Responsible for the
    construction, through the demolition of the bone tissue
    “deposition” process trough the “resorption”
    process

    The balance between the two processes is altered, the demolition of the
    bone tissue occurs rapidly due to a notable resorption by the osteoclasts and
    an excess of abnormal neoformation and an increase in connective tissue
    and blood vessels follows.
    LOCATION

    Paget’s disease is localized and affects one or a few


    bones such as tibia, femur, humerus, spine, unlike
    osteoporosis which is a generalized bone disease
    The risk of onset of the disease increases with age.
    Men are more affected !
    DRUGS AND CARE

    There isn’t cure but some drugs can control the


    disease and reduce pain , such as biphosphonates.
    Early diagnosis and drug treatment are effective in
    controlling the disease
    AETIOLOGY

    The causes is unknown but the etiological hypotheses are


    two:

    1. Predisposition provided by hereditary genetic factors


    like the RANK (receptor activation of nuclear factor
    KB) which activates the osteoclasts, and the
    sequestosome gene, which encodes the p62 protein.

    2. Infection by a paramyxovirus
    SINGS AND SYMPTOMS

    The most common is bone pain. Others are: high


    temperature, bone deformity (as enlarged jaw),
    weakness, hearing loss, headache, dizziness, spinal
    stenosis
    POSSIBLE MEDICAL CONDITIONS

    Fractures, osteoarthritis, osteosarcoma, deafness,


    cardiovascular diseases, cranial nerve paralysis,
    paraplegia
    DIAGNOSIS

    It can be established using the following instrumental


    investigations:

    X-RAY of the skeletal segment concerned (first choice


    investigation)

    Bone scintigraphy, to determine the extent of the disease

    CAT to monitor the course of the disease

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