Abdul Jabbar Virology3

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Virology/Mycology

Chain of Infections
PRESENTED BY: Abdul Jabbar

BS-AHS MLT 5TH Semester

Submitted To: Madam Mahnoor Nadeem


INTRODUCTION
.
The “Chain of Infection” describes the process of
infection that begins when an infectious agent
leaves its reservoir through a portal of exit, and is
transmitted by a mode of transmission entering
through a portal of entry to infect a susceptible host
Chain of Infection (Visual Concept)

1 . Agent

6 .Susceptible 2 . Reservoir
Host

5. Portal of 3. Portal of
Entry Exit

4 . Mode of
Transmission
Infectious Agent
•Microorganisms that are responsible for causing disease production:
•Viruses Protozoa and Helminthes
•Bacteria •Parasites
•Fungi •Prions*
2 . Reservoirs of Infection
reservoir of an infectious agent is where the infectious agent
normally lives and multiplies human
Reservoirs of Infection - Humans

Human Reservoir: An
infected person with or without apparent
symptoms who can transmit this agent to others.

Two types of human reservoir exist:


• Cases: persons with symptomatic illness
• Carriers: persons appearing asymptomatic or symptomatic

Types of Carriers:
1. Asymptomatic carrier: An infected individual that shows no
symptoms. Although unaffected they can transmit disease to
others.
2. Symptomatic carrier: The carrier state may occur during the
incubation period, convalescence, and post convalescence of
an individual with a clinically recognizable disease (eg.
influenza, childhood diseases).
Reservoirs of Infection - Animals
•Diseases that can be passed from animals to humans
(eg. Lyme disease, swine flu)
•Plague (rodents carrying infected fleas)
Reservoirs of Infection - Environment
Natural Environmental Reservoirs: Soil, and water

Soil: Agents live and multiply in the soil. Examples:

• Tetanus and botulism spores


• Bacillus cereus causing gastroenteritis
• Listeria monocytogenes causing gastroenteritis and meningitis

Water: Can be the primary reservoir for Legionnaires’ bacillus,


Vibrio cholera, Cryptosporidium, Giardia, enteroviruses and
other agents.
Portal of exit is the route an infectious agent leaves the host.
The common cause of disease transmission.

3 . Portal of Exit

Examples:
•Respiratory tract
•Gastro-intestinal tract
•Skin lesions
4- Modes of Transmission Direct

Direct contact
• Skin-to-skin contact, kissing, and sexual
intercourse.

4. Modes of Transmission Indirect


Indirect transmission of an agent from a reservoir to a susceptible host
through suspended particles, vehicles or vectors.

• Air particles: Dust may contain agents eg. fungal spores. Droplet nuclei
residues (dried droplet spread) coughed or sneezed into the air usually less than
5 µ (microns) in size.
5 . Portal of Entry
An agent enters a susceptible host through a portal of
entry. .
Incubation Period: The period from exposure to
infection to the onset of symptoms or signs of
infectious disease.
The length of incubation period depends on:
• The portal of entry.
• The rate of growth of the organism in the host.
• The dosage of the infectious agent.
The host resistance
6 . Susceptible Host

The host: is a person or other living


organism that can be infected by an
infectious agent under normal conditions

A susceptible host is the final link in the chain of infection.


Susceptibility of a host depends on:
•General factors
•Genetic factors
•Specific acquired immunity
Public Health Actions to Break the chain

mbranes. • Use face shield during high risk procedures


rbed through exposed eyes, nose • Carry out good housekeeping
• Use hand hygiene

• Dispose of wound dressings carefully and properly


r by wound drainage or skin • Wear personal protective equipment
ntact. • Maintain healthy intact skin
• Use hand hygiene
ANY QUESTION....?

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