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    Neonatal Jaundice

    Uploaded by

    Sandhya Basnet

    Copyright:

    © All Rights Reserved
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    Neonatal Jaundice

    Uploaded by

    Sandhya Basnet
    9 views6 pages

    Copyright

    © © All Rights Reserved

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    PPT, PDF, TXT or read online from Scribd

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    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    9 views6 pages

    Neonatal Jaundice

    Uploaded by

    Sandhya Basnet

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 6

    1

    Neonatal Jaundice
    Prepared by
    Sandhya basnet
    Learning Objectives
    • At the end of the session students will be able
    to explain pathophysiology of neonatal
    jaundice
    2
    Definition
    • Yellowish discoloration of the skin and the mucosa
    caused by the accumulation of excess of bilirubin in
    tissue and plasma (serum bilirubin >7mg/dl)
    • Around 60% of term and 80% of preterm baby
    becomes visibly jaundiced in the first week of life.
    • About 30-50 % term newborn develops clinical
    jaundice.
    Bilirubin metabolism
    RES Circulation Hepatocyte

    UDP -
    glucaronyl
    UDP -
    Senescent Heme Bilirubin Bilirubin Glucuronyltransferase
    RBCs +Albumin

    Urobilinogen Bilirubin
    conjugated
    MRP2 transport
    Fecal excretion protein
    (stercobilin) bacteria

    Bowel Ampulla of Vater Bile Ducts Canaliculus


    Assignment
    • Explain pathophysiology of neonatal
    jaundice.
    • What are the causes of pathological jaundice
    in neonates.
    54

    Thank you!!!

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