Fluoride
Fluoride
Fluoride
• Introduction
• Fluoride in environment
• Sources of fluoride
• Metabolism of fluoride
• Mechanism of action of fluoride
• Fluoride delivery methods
• Toxicity of fluorides
• De-fluoridation of water
• Conclusion
INTRODUCTI
ON
LITHOSPHERE
• There are more than 50 fluoride containing minerals, many of which
are silicates.
• Is widely distributed in the earth’s crust where it averages 300 ppm
and constitutes about 0.087% of its weight.
BIOSPHERE
• Normal level of fluoride in plants is about 2-20 mg of dry weight.
• Leafy vegetables contain about 11-26 mg fluoride on dry weight
basis.
• Dried fish contain 20-40 ppm of fluoride.
HYDROSPHERE
• Concentration of fluoride varies, water with high fluoride content
are found at the foot of high mountains and in areas with
geological deposits of marine origin.
• Fluoride content of water obtained from river, lakes are below 0.5
mg/kg.
• Sea water contains 1.2 to 1.4 mg/kg of fluoride.
ATMOSPHERE
ABSORPTION
• Occurs mainly through stomach and also absorbed via lungs and
intestine.
• Main factors influencing absorption are\
i. Species variation
ii. Concentration of fluorides ingested
iii. Solubility and degree of ionization of the compounds
iv. Other dietary constituents
• An initial increase
• Followed by a rapid fall for about 1hour(distribution/alpha
phase)
• Thereafter a slower decline (elimination/beta phase)
DISTRIBUTION
FLUORIDE IN BONE
• 99% of fluoride is found in calcified tissue in human body.
• Being reversibly bound to bone there are two phases of fluoride
removal form calcified tissue:
i. A rapid process of the order of weeks.
ii. Slow removal, taking years, due to osteoclastic resorption of
bone.
FLUORIDE IN SALIVA
There are two major sources:
•Secretion from salivary glands is about 0.007 to 0.05 ppm.
•Introduction into the mouth from food, water, and fluoride
preparations.
FLUORIDE IN ENAMEL
Amount of fluoride in outer enamel is 2,200- 3,200 ppm.
FLUORIDE IN DENTINE
Amount of fluoride in dentine is 200-300 ppm.
FLUORIDE IN CEMENTUM
• Amount of fluoride in cementum is 4,500 ppm.
DISTRIBUTION TO FOETUS
• Some state that placenta acts as complete barrier to fluoride others
state that it is only partial.
• Some also state that placenta only acts as a barrier when there is
sudden increase in the maternal plasma fluoride level.
EXCRETION OF FLUORIDES
• Fluoride is excreted in urine, lost through sweat, and excreted in
the faeces.
• It also occurs in traces in breast milk, saliva, hair and tears.
• About 10-25% of the daily intake of fluoride is not absorbed and
is excreted in the faeces.
1) By reducing
bacterial acid
production and
acidurance.
2) By
reducing the
equilibrium
solubility of
apatite.
3)By fluoridation
of apatite crystal
surfaces
reducing the
dissolution rate .
REMINERALIZATION OF INCIPIENT
LESIONS
• Newly erupted teeth often have hypomineralized areas that are prone
to dental caries.
• Post eruptive maturation involves deposition of minerals into
hypomineralized areas.
• Fluoride increases the rate of mineralization of those hypomineralized
areas.
in lower
in higher concentra
concentra tion,
fluoride is
tions
fluoride is bacteriost
bactericida atic
l
1) Enolase;
maybe 2) Bacterial 3)
partially phospha- Potassium
inhibited by tases transport
0.5-1 ppm
MODIFICATION IN TOOTH MORPHOLOGY
A) TOPICAL FLUORIDES
Are directly placed on the
teeth. E.g. dentifrices.
B) SYSTEMIC FLUORIDES
They circulate through the
blood stream. E.g. Mouth
wash, fluoride tablets.
TOPICAL FLUORIDES
Those delivery systems which provide for a local chemical reaction to
exposed surfaces of erupted dentition.
Fluoridated
Foam
pastes
1) Sodium
fluoride
2)
Stannous
fluoride
3)
Acidulated
phosphate
fluoride
NEUTRAL SODIUM FLUORIDE
Calcium fluoride interferes with further diffusion of fluoride and this sudden
stop of entry of fluoride is CHOKING OFF EFFECT.
Fluoride then slowly leaches out acting as reservoir for fluoride release.
DISADVANTAGE OF NEUTRAL
SODIUM
FLUORIDE SOLUTION
• The patient must make four visits to the dentist within a relatively
short period of time.
STANNOUS FLUORIDE
METHOD OF PREPARATION
• 8% stannous fluoride solution, the content of one capsule which is 0.8
grams is dissolved in 10ml of distilled water in a plastic container and
the solution is shaken briefly.
TECHNIQUE OF APPLICATION
(Muhler’s Technique)
Each tooth surface is cleaned with pumice or other dental cleaning agent for
5-10 seconds.
Stannous fluoride is applied using the paint on technique and the solution is
kept for 4minutes. Repeat application are made every 6 months or more
frequency if the patient is susceptible to caries.
MECHANISM OF ACTION OF
STANNOUS FLUORIDE
DISADVANTAGES OF STANNOUS
FLUORIDE
TECHNIQUE OF
APPLICATION
Oral prophylaxis
Patient is instructed not to eat, drink or rinse his mouth for at least
30minutes.
MECHANISM OF ACTION OF
ACIDULATED PHOSPHATE
FLUORIDE
DISADVANTAGES OF ACIDULATED
PHOSPHATE FLUORIDE
• Practical difficulties like the teeth should be kept wet for 4minutes
and repeated applications.
• It has unpleasant taste.
• It cannot be stored in glass containers.
Characteristics of professionally applied topical
fluorides
Percentage 2% 8% 1.23%
1) FLUORIDE
DENTIFRICES
2) GELS
3) RINSES
DENTIFRICES
Home use:
By dissolving 200mg sodium fluoride tablet in 5 teaspoons of fresh
clean water.
In schools:
Authorities can buy packets of sodium fluoride powder (2g powder
in each packet) and dissolve this powder in 100ml of water to
make a 0.2% solution.
Community water
fluoridation Salt fluoridation
Fluoride
Milk fluoridation tablets/drops/lozen
ges
COMMUNITY WATER
FLUORIDATION
Sodium
Fluorspar
fluoride
Sodium silico
Silico fluorides
fluoride
ADVANTAGES
• Effective public health measure.
• Target population- school children.
• Quite economical.
LIMITATIONS
• Need for co-operation from school authorities.
• Intermittent fluoride exposure.
SALT WATER FLUORIDATION
ADVANTAGES
• It does not require a community water supply.
• It permits individuals to accept or reject it.
• Non-fluoridated salt, like non-iodized salt, can be made available to
the population.
LIMITATIONS
• There may be large variation in salt intake in different groups of
people.
• If there are multiple drinking water sources which have fluoride
concentration.
• Requires refined salt produced with modern technology and a high
level of technical expertise.
MILK FLUORIDATION
CLINICAL FEATURES
• Lusterless, opaque white patches in enamel which may become
mottled, striated or pitted.
• Mottled areas may becomes stained yellow or brown.
• Hypoplastic areas may also be present to such an extent in
severe cases that normal tooth form is lost.
SKELETAL FLUOROSIS
Occurs from ingestion of very high amounts of
fluorides for long periods of time.
SYMPTOMS
• Severe pain in the back bones, joints, hips and
stiffness.
• Outward bending of legs and hands is seen in
advanced stages. (KNOCK-KNEE SYNDROME)
• Fluoride may lead to blocking and calcification of
blood vessels causing cardiac problems.
• In its severest form, crippling fluorosis, spine
becomes rigid and the joints stiffen, immobilizing
the patient.
DE-FLUORIDATION OF WATER
The unit holds 22 liters of water, which is filled into the upper chamber.
RAPID MIX:
• Coagulant is rapidly and uniformly dispersed throughout a single or
multiple phase system.
• Rapidly mixed for a period of 30 to 60 seconds with a speed of 10 to
20 rpm.
• This helps in formation of microflocs and results in proper utilization
of chemical coagulants.
FLOCCULATION:
FILTRATION
• No regeneration of media.
• No handling of caustic acids and alkalis
• Only readily available chemicals used in conventional municipal
water treatment are required.
• Adaptable for domestic use.
• Simplicity of design, construction, operation and maintenance.
• Highly efficient removal of fluoride to desirable levels.
• Little wastage of water.
• Needs minimum of mechanical and electrical equipment.
When used appropriately fluoride is a safe and effective agent that can be
used to prevent and control dental caries. Fluoride has contributed to
improved dental health of people all over the world. Fluoride is needed
regularly throughout life to protect teeth against tooth decay. However,
since fluoride is considered to be a double-edged sword, it must be used
judiciously so that dental caries is prevented and the deleterious effects
of dental and skeletal fluorosis avoided.
REFERENC
E