Attention-Deficit Hyperactivity Disorder
Attention-Deficit Hyperactivity Disorder
Attention-Deficit Hyperactivity Disorder
Hyperactivity Disorder
ADHD – Key Features
A persistent pattern of inattention or hyperactivity-
impulsivity more frequently displayed and more
severely displayed than in typical individals
Six symptoms of inattention
And/Or
Six symptoms of hyperactivity-impulsivyt
Before
Age 7
“6-6-6”
Diagnostic Features
Inattention may manifest itself in academic,
occupational or social situations.
Hyperactivity may manifest itself by
fidgetiness or squirming in one’s seat.
Impulsivity may manifest itself as impatience,
difficulty in delaying responses, and blurting
out answers in class.
Both symptom clusters impact academics and
socialization.
ADHD – Dx Criteria
A. Either (1) or (2):
(1) inattention: six (or more) of the following symptoms of inattention have
persisted for at least 6 months to a degree that is maladaptive and
inconsistent with developmental level:
Inattention
(a) often fails to give close attention to details or makes careless mistakes in
schoolwork, work, or other activities
(b) often has difficulty sustaining attention in tasks or play activities
(c) often does not seem to listen when spoken to directly
(d) often does not follow through on instructions and fails to finish school work,
chores, or duties in the workplace (not due to oppositional behavior or failure to
understand instructions)
(e) often has difficulty organizing tasks and activities
(f) often avoids, dislikes, or is reluctant to engage in tasks that require sustained
mental effort (such as schoolwork or homework)
(g) often loses things necessary for tasks or activities (e.g., toys, school
assignments, pencils, books, or tools)
(h) is often easily distracted by extraneous stimuli
(i) is often forgetful in daily activities
ADHD – Dx Criteria
A. Either (1) or (2):
(2) hyperactivity-impulsivity: six (or more) of the
following symptoms of hyperactivity-impulsivity have
persisted for at least 6 months to a degree that is
maladaptive and inconsistent with developmental level:
Impulsivity
(g) often blurts out answers before questions have been
completed
(h) often has difficulty awaiting turn
(i) often interrupts or intrudes on others (e.g., butts into
conversations or games)
ADHD
Either (1) or (2):
– Dx Criteria
(2) hyperactivity-impulsivity: six (or more) of the following
symptoms of hyperactivity-impulsivity have persisted for at
least 6 months to a degree that is maladaptive and inconsistent
with developmental level:
Hyperactivity
(a) often fidgets with hands or feet or squirms in seat
(b) often leaves seat in classroom or in other situations in
which remaining seated is expected
(c) often runs about or climbs excessively in situations in
which it is inappropriate (in adolescents or adults, may be
limited to subjective feelings of restlessness)
(d) often has difficulty playing or engaging in leisure activities
quietly
(e) is often "on the go" or often acts as if "driven by a motor"
(f) often talks excessively
ADHD – Dx Criteria
B. Some hyperactive-impulsive or inattentive symptoms that
caused impairment were present before age 7 years.
Norepinephrine dysregulation
Hypofrontality
Arousal-seeking
Executive dysfunction
Causes
Neurological : FMRI & PET studies indicate frontal &
prefrontal areas, cerebellum & basal ganglia are structurally
smaller & have reduced blood flow.
Reduced activity in these areas & less gray matter
Cognitive aspects of ADHD related to impairment in frontal
& prefrontal areas,
Hyperactivity related to impairment in basal ganglia & /or
cerebellum
Certain chemicals in the brain ( neurotransmitter) play a major
role in ADHD behavior, especially dopamine and
norepinephrine
Genetic factors : more common in biol. Relatives of children
with ADHD. More likely in siblings of ADHD.
Probability of ADHD much higher in identical T pair.
? Defective gene inherited. Dopamine transporter gene
Brain injury : encephalitis, epilepsy, fetal exposure, toxemia, &
preschoolers exposed to high levels of lead have a higher risk of
developing ADHD
Different EEG patterns occur in brains of kids with ADHD
Environmental factors : family pathology, parental personality
problems, either hysteria/personality disorder,
Constant friction b/w parents & child subsequent to child’s behavior
causes more problems for an ADHD .
Poor parenting, disruptive family life, poor schooling , defective
management by parent, teachers & others prolonged emotional
deprivation, stressful psychic events
Predisposing factors : temperament, demands of society to adhere to
routine way of behaving & performing
The neurological basis of attention :
Abnormalities of brain structure reported in ADHD
– Total brain volume 5% smaller, cerebellar
volumes smaller, caudate volumes smaller – Frontal
lobe, basal ganglia, cerebellum – Findings
inconsistent
Functional studies – Abnormal function of the
fronto-cortical-striatal- thalamic circuitry – Major
components of this circuitry and other regions
implicated in ADHD, Activation of other areas not
seen in controls –(2005).
Exec fxing of Frontal cortex : Response inhibition :
Neurological disorders that impair attention:
Damage to the neural pathways supporting attention –
Traumatic Brain Injury (~20%) – 15% between 6-12 months
after injury – 21% more than 1 year after injury
Stroke – Children with stroke have a significantly increased
risk of ADHD – 15/25 stroke vs 6/25 control
Lesion volume not associated with ADHD traits. Small
lesions of the putamen associated with ADHD – ADHD: 6/7
with putamen lesion versus 2/6 with no putamen lesion
Encephalitis – Spina-bifida with hydrocephalus (~30%)
Functional impairment of attention networks – Epilepsy – ?
ADHD in 4% of children with epilepsy, ADHD in 70% of
children with severe epilepsy
Tourette syndrome (>50% ADHD clinical groups)
Associated Physical Findings
No specific physical features associated with
ADHD.
Some minor physical abnormalities:
Hypertelorism (atypically long distance between
eyes)
Highly arched palate
Low-set ears
60
50
40
30
20
10
0
Monozygotic Dizygotic
Familial Pattern
Most studies have found greater concordance
rates (% matches) with MZ twins compared to
DZ twins.
Problems?
Environment of MZ twins more similar than
environment of DZ twins.
Is it genetics?
Familial Pattern
Studies also suggest higher prevalence of
Mood and anxiety disorders
Learning Disorders
Substance-Related Disorders