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    Ayu

    Uploaded by

    Aayu Salunkhe

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd

    Ayu

    Uploaded by

    Aayu Salunkhe
    7 views11 pages

    Copyright

    © © All Rights Reserved

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    PPTX, PDF, TXT or read online from Scribd

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    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    7 views11 pages

    Ayu

    Uploaded by

    Aayu Salunkhe

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 11

    ✓ INTRODUCTION

    The real challenge in the development of an


    oral controlled-release drug delivery system
    is not just to sustain the drug release, but
    also to prolong the presence of the dosage
    form within the gastrointestinal tract (GIT)
    until the drug is completely released at the
    desired period of time. Garg and Gupta classified the
    gastroreten-tive dosage forms into four main classes:
    (i) floating systems
    (ii) expandable systems
    (iii) bioadhesive systems
    (iv) high density systems
    # Floating systems are of two types:

    (1) effervescent systems :-

    depending on the generation of carbon dioxide gas


    upon contact with gastric fl uids,

    (2) non-effervescent systems :-

    The non-effervescent systems can be further divided


    into four sub-types, including :-
    hydrodynamically bal-anced systems.
    microporous compartment systems.
    alginate beads.
    hollow micro-spheres/microballons.
    super-porous hydrogels.
    ✓ FACTORS AFFECTING THE GRDDS :-

    number of factors that affect their bioavailability and


    efficacy of the gastro retentive
    system :-

    • Density

    • Size

    • Shape of dosage form

    • Single or multiple unit formulation


    • Single or multiple unit formulation

    • Fed or unfed state

    • Nature of meal

    • Caloric content

    • Gender

    • Age

    • Biological factors
    ✓ AIM & OBJECTIVE :-

    The aim of this review is to investigate, compile and present


    the recent as well as past literatures in more concise way
    with special focus on various gastro retentive approaches
    that have recently become leading methodologies in the
    field of site-specific orally administered controlled release
    drug delivery.
    ✓ OBJECTIVE :-

    1) Preformulation studies
    2) Selection of the appropriate excipients
    3) Formulation of pulsatile floating tablet
    4) To evaluate and characterize the prepared
    formulations
    5) Stability studies of prepared optimized formulation
    6) To study pharmacokinetics of pulsatile floating tablet
    ✓ LIT. SURVEY :-

    B. Sowmya :-

    GRDDS has gained immense popularity in recent years in


    the field of oral drug delivery. It is widely employed
    approach to retain the dosage form in the stomach for an
    extended period of time and release the drug slowly that
    can address many challenges associated with conventional
    oral delivery, including poor bioavailability. In order to
    understand various physiological difficulties to achieve
    gastric retention, we have summarized factors influencing
    and various strategies for gastric retention.
    V.Satyanarayana :-

    The main objective of present research work is to


    formulate the floating tablets of esomeprazole using
    factorial design.The floating tablets of atenolol were
    prepared employing different concentrations of
    hydroxypropyl methylcellulose (HPMC) and sodium
    bicarbonate in different combinations by direct
    compression technique using factorial design.
    esomeprazole was chosen as a model drug because it is
    poorly absorbed from the lower gastrointestinal tract.
    Sanjay Dey :-

    The purpose of this research was to develop gastro-


    retentive delivery system of esomeprazole which, after oral
    administration should have the ability to prolong gastric
    residence time with desired in vitro release profile. The
    tablets were prepared by direct compression technique,
    using natural gum such as xanthan gum and guar gum . The
    tablets were evaluated for physical characteristics viz.
    hardness, friability, weight variation, content uniformity,
    and floating capacity. tablets containing combination of
    xanthan gum and guar gum showed better floating capacity

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