Introduction in Medical Microbiology June 2020 Online Class

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MEDICAL MICROBIOLOGY

 Lesson plan
 By the end of the lesson the the
learner should be able to;
 Define medical microbiology

 history of microbiology

 Mechanism of pathogenesis
INTRODUCTION
 Microbiology – Study of micro organisms that are too small to
be seen with naked eyes
 Derived from 2 Greek words ‘Mikros’- small & ‘Bios’ – life

 Medical Microbiology - study of causative agents of


infectious diseases of humans and their reactions to such
infections.
 Deals with etiology, pathogenesis, laboratory diagnosis,
specific treatment and control of infection
CLASSIFICATION OF MICROORGANISMS
Kingdom Protista
5 major groups
Viruses

Eukaryotes Prokaryotes
 Fungi Bacteria
 Algae

 Protozoa
Eu-true, Karyote- Nucleus. Have true membrane bound nucleus & organelles.
Pro – primitive, karyote-Nucleus. No internal bound nucleus & organelles
MODERN MEDICAL MICROBIOLOGY
 Bacteriology – the science of bacteria, the causative
agents of a member of infectious diseases.
 Virology – the science of viruses, non-cellular living
systems, capable of causing infectious diseases in
man.
 Immunology – the science which concerned with
mechanisms of body protection against pathogenic
microorganisms and foreign cells and substances.
 Mycology – the study of fungi pathogenic for man.
 Protozoology – which deals with pathogenic
unicellular animal organisms.
DEFINITION OF TERMS
Microbiology
Microscopy – technical field of using microscopes
to view objects not visible with naked eye
Microbiological methods – used to study microbes
like culturing, plating, staining.
Sterilization – Destruction of all
microbes(pathogenic/non pathogenic) & spore
.Disinfection – Reducing the no. of m.org.
Aseptic – Free from pathogens
Septic – Decay bacterial contaminant
Antibiotic – stops multiplication of bacteria.
Commensal – benefits from another org. without
causing harm
DEFINITION OF TERMS
Pathogen – can cause disease- pathogenecity
Septicemia – Blood poisoning by toxins
Nosocomial – Hospital acquired infections.
Exotoxin – A toxic protein produced by bacteria and
released into the environment
.Endotoxin – An LPS associated with outer
membrane of gram negative bacteria.
Aetiology – cause of disease
Bacterimia – Presence of bacteria in blood
stream
HISTORY
1680s: Leeuwenhoek discovers bacteria. 1720s:

Benjamin Martin describes a germ theory of disease in his book A New


Theory of Consumptions
 1890s: Robert Koch sets guidelines for how to prove that a particular
microbial agent is responsible for a particular disease. Koch's postulates
state that:
The suspect microorganism must be routinely isolated from patients
with a particular illness;
 The microorganism must be grown in pure culture in vitro;

When the pure culture is inoculated into a new host, it must cause the
same illness;
The same microorganisms must be reisolated from new host.

1929: Alexander Fleming discovers penicillin.

1939: Florey and co-workers find a way to isolate penicillin.


IMPORTANCE OF MICROBIOLOGY
•In development of pharmaceutical pdcts
•Use of quality control methods in food and
dairy pdcts production
•Manufacture of many foods-fermented dairy
products, alcoholic beverage
•Biotechnology

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