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Dose Calculation: Calculation of Doses Based On Age and Medical Condition To Be Treated

1. The document discusses calculating drug doses based on factors like age, weight, and medical condition. It provides rules for calculating doses for children based on age, weight, and other factors. 2. Sample problems demonstrate using the rules to calculate drug doses for patients of different ages and weights. For example, calculating the dose of atropine sulfate for a 7-year-old patient. 3. The document also provides a parental dosage schedule for a hypothetical drug based on age and condition. An example calculation is shown for determining the IV dose for a neonate based on their weight.

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Lance Reyes Aguilar
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309 views12 pages

Dose Calculation: Calculation of Doses Based On Age and Medical Condition To Be Treated

1. The document discusses calculating drug doses based on factors like age, weight, and medical condition. It provides rules for calculating doses for children based on age, weight, and other factors. 2. Sample problems demonstrate using the rules to calculate drug doses for patients of different ages and weights. For example, calculating the dose of atropine sulfate for a 7-year-old patient. 3. The document also provides a parental dosage schedule for a hypothetical drug based on age and condition. An example calculation is shown for determining the IV dose for a neonate based on their weight.

Uploaded by

Lance Reyes Aguilar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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DOSE CALCULATION:

CALCULATION OF DOSES BASED


ON AGE AND MEDICAL
CONDITION TO BE TREATED
LEARNING OUTCOMES:

1. Calculate doses based on factors of age, and medical condition


to be treated.
2. Calculate dose for single and combination chemotherapy
regimens.
 
CALCULATION

OF DOSES FOR CHILDREN:
Drug Doses Based on Age and Weight:
RULES:

a. Clark’s Rule, based on weight:


Dose for child =
b. Young’s Rule, base on age:
Dose for child =
c.   Cowling’s Rule:

Dose for child =


d. Fried’s Rule of infant:
Dose for infant =

Note: The value of 150 in Fried’s rule was an estimate of the age
(12.5 years or more 150 months) of an individual who would
normally receive an adult dose, and the number 150 in Clark’s rule
was an estimate of the weight of an individual who likewise would
receive an adult dose.
 
SAMPLE

PROBLEMS:
1. If 150mg/kg body weight is the usual initial dose. How many
milligrams should be administered to a 154 lbs patient?

= 70kg

10,500mg
2.   The usual adult for atropine sulfate is 0.5mg. What is the dose

for a 7 years of age?


Young’s Rule:
Given: Age = 7 years old
Adult dose = 0.5mg
Dose for child =
Dose for child =
Dose for child = 0.18mg
3.   The adult dose of a drug solution is 5ml. What would be the dose

for a child weighing 80 lbs?


Clark’s Rule:

Dose for child =

Dose for child = 2.67ml


PARENTAL DOSAGE SCHEDULE FOR A HYPOTHETICAL DRUG
BASED ON PATIENT AGE AND CONDITION BEING TREATED
DOSE ROUTE FREQUENC
Y
Adults
Urinary tract infection 250 mg IV or IM q12h
Bone and joint infections 2g IV q12h
Pneumonia 500 mg-1 g IV or IM q8h
Mild skin infections 500 mg-1g IV or IM q8h
Life threatening infections 2g IV q8h
Lung infections (normal kidney function) 30-50 mg/kg IV q8h
(NMT 6 g/day)
Neonates (up to 1 month) 30 mg/kg IV q12h
Infants and Children (1 month to 12 years) 30-50 mg/kg IV q8h
(NMT 6 g/day)
By using the table, calculate the IV drug dose for a 3-pound 3-ounce
neonate.
3 pounds = 3 x 454 g = 1362
3 ounces = 3 x 28.35 g = 85 g
Weight of neonate = 1362 g + 85 g = 1447 g
1447 g/1000 = 1.447 kg
30 mg/kg X 1.447 kg = 43.4 ng every 12 hours, answer.
SPECIAL DOSING CONSIDERATIONS IN CANCER
CHEMOTHERAPY
Chemotherapy
 Applies to the treatment of disease with chemical drugs or
chemotherapeutic agents
 Primarily associated with the treatment of cancer patients and is
considered the mainstay of such treatment in that it is effective in
widespread or metastatic cancer, whereas treatments such as surgery
and radiation therapy are limited to specific body sites.
 Chemotherapeutic agents most often are administered orally, by
intravenous injection, or by continuous intravenous infusion.
SAMPLE
   PROBLEM:

1. Regimen:
Cycle: 28 days; repeat for 2-8 cycles
Vinorelbine, , IV, D 1, 8, 15, 22
Cisplatin, , IV, D 1
 

For each of vinorelbine and cisplatin, calculate the total
intravenous dose per cycle for a patient measuring 5 feet 11 inches
in height and weighing 175 lbs. From the nomogram for
determining BSA: a. find the patient’s BSA and b. calculate the
quantity of each drug in the regimen.

a. BSA =

b. Vinorelbine: 25 mg x 2 (BSA) x 4 (days of treatment) = 200mg


Cisplatin: 100mg x 2 (BSA) x 1 = 200mg

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