COVID-19: Brian, Fernando, Jason, Felita

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COVID-19

Brian, Fernando, Jason, Felita


Introduction of COVID-19
Coronaviruses are a large family of viruses that are known to
cause illness ranging from the common cold to more severe
diseases such as Middle East Respiratory Syndrome (MERS) and
Severe Acute Respiratory Syndrome (SARS).

A novel coronavirus (COVID-19) was identified in 2019 in


Wuhan, China. This is a new coronavirus that has not been
previously identified in humans.

This course provides a general introduction to COVID-19 and


emerging respiratory viruses and is intended for public health
professionals, incident managers and personnel working for the
United Nations, international organizations and NGOs.
Facts about COVID-19
COVID-19 is usually transmitted by droplets of water, and even
when it is not in a living body it can live on surfaces for days.
Someone who is infected may possibly show zero symptoms,
however are still able to infect others. If a person was infected
and then recover, it doesn't guarantee that they will not be
reinfected. People of all ages can be infected, but the elderly are
more prone to receive worse symptoms
How does the virus enters our
body and affected the body
When the virus gets in your body, it comes into contact with the mucous membranes that line your nose,
mouth, and eyes. The virus enters a healthy cell and uses the cell to make new virus parts. It multiplies, and
the new viruses infect nearby cells, so the virus replicate in mucous membrane, as it multiply it goes down
the respiratory tract, inflaming the areas infected and this can range from mild cough to pneumonia.

About 14% of COVID-19 cases are severe, with an infection that affects both lungs. As the swelling gets
worse, your lungs fill with fluid and debris.

You might also have more serious pneumonia. The air sacs fill with mucus, fluid, and other cells that are
trying to fight the infection. This can make it harder for your body to take in oxygen. You may have trouble
breathing or feel short of breath. You may also breathe faster, In critical COVID-19 cases around 5% of total
cases the infection can damage the walls and linings of the air sacs in your lungs. As your body tries to fight
it, your lungs become more inflamed and fill with fluid. This can make it harder for them to swap oxygen
and carbon dioxide.

You might have severe pneumonia or acute respiratory distress syndrome (ARDS). In the most critical cases,
your lungs need help from a machine called a ventilator to do their job.

There’s evidence that 20-30% of the critically ill patients can develop clots in the lungs, heart, brain and legs,
some of which are life threatening.
Depends on how severe it is, you might still have coughs after recovering from COVID, and others have scars
in their lungs, which might potentially be a permanent damage.
Symptoms of the COVID-19
According to a study from researchers at King's College London, 6 Symptom Clusters exist. Each
seperated clusters differ in their severity and their need for respiratory support during hospitalization.
• “Flu-like” with no fever: Headache, loss of smell, muscle pains, cough, sore throat, chest pain, no
fever

• “Flu-like” with fever: Headache, loss of smell, cough, sore throat, hoarseness, fever, loss of appetite

• Gastrointestinal: Headache, loss of smell, loss of appetite, diarrhea, sore throat, chest pain, no cough

• Severe, level 1 with fatigue: Headache, loss of smell, cough, fever, hoarseness, chest pain, fatigue

• Severe, level 2 with confusion: Headache, loss of smell, loss of appetite, cough, fever, hoarseness,
sore throat, chest pain, fatigue, confusion, muscle pain

• Severe, level 3 with abdominal and respiratory pain: Headache, loss of smell, loss of appetite, cough,
fever, hoarseness, sore throat, chest pain, fatigue, confusion, muscle pain, shortness of breath,
diarrhea, abdominal pain

Categorizing the symptoms according to these 6 clusters allow doctors to predict who is most at risk
and helps greatly with the clinical management of COVID-19
The new variants of the
COVID-19
• Virus has genetic code. Inside a virus, there are nucleotides
that form their genetic sequence. What happens when a new
variant appear is, when replicating itself, a mistake happens
during the replication process.
• These new variants are actually quite frequent, however most
of the changes does not affect the behavior or the effects of
the virus.
• Some change makes the virus weaker, these strains are less
likely to infect or survive, thus they will eventually die out
• However some strains become slightly stronger, or slightly
more resistant, these strains are more likely to spread and
multiply
Variants that has been
identified
• From United Kingdom first detected in the fall of 2020
• Spreads more easily
• Increase chance of death
• From South Africa first detected early October 2020
• From Brazil first detected early January 2021
• May affect its ability to be recognized by antibodies
• lineages From California first detected early summer 2020
• Increase infectivity
• More transmissible
Possible cure for the COVID-19
• As of now, the vaccines are designed to be
effective against the variants in most cases,
however it's not a guarantee, a new strain
might appear which the vaccines does not
work on.
• That is why we must reduce the number of
cases by following the safety protocol. If we
reduce the amount of cases, the chance that
a new dangerous strain will appear will be
much lower and we can eventually stop the
spread of COVID-19 faster.
• Optimal supportive care includes oxygen for
severely ill patients and those who are at risk
for severe disease and more advanced
respiratory support such as ventilation for
patients who are critically ill.
• Dexamethasone is a corticosteroid that can
help reduce the length of time on a ventilator
and save lives of patients with severe and
critical illness.

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