Nutrigenomic:
Introduction and
Application
Maharani Retna Duhita ,M.Sc.,PhD.Med.Sc
QS Al Baqarah 168-169
You are what you eat.
• Higher energy levels
• We i g h t l o s s / w e i g h t g a i n
• Lower blood pressure
• Lower triglyceride
• Decreased heart disease risk
• Lower blood glucose levels
• Decreased diabetes risk
Does diet cause disease?
THE ROAD ITS COMPLEX
Metabolic Differences, Physical Activity, Other
Dietary Component., Cooking Method
How do we solve
the problem?
NUTRIGENOMIC
W H AT I S T H E D E F I N I T I O N
Study of the effect
of nutrition on
the gen expression
Application of
Nutrigenomic
W H AT W E ' R E A B O U T
.
Let's pick a
disease
Diabetes in Numbers 2012 (Nature
485: S2-S3)
Let's pick a
disease Let’s pick simple
dietary factor
ASIAN FOOD
EUROPEAN FOOD
Comparation
ASIAN FOOD
Mirnalini et.al. (2008) Energy and nutrient intakes: Findings from the Malaysian
Nutrition Survey (MANS).
EUROPEAN FOOD
Mulla et. al.(2013)Adult macronutrient intake and physical
Capability in the MRC National Survey of Health and
Development; Age & Ageings
The complexity of
interaction
W H AT T H E I R A B O U T
.
E N V I R O M E N TA L R I S K FA C T O R S
Genetic Factors EXPOSURE
Hypertension,
Diet, smoking, stress diabetes,obesity
PHENOTYPE MEASURABLE
TRAITS
Myocardial infarction,
stroke Artherosclerosis
Recap of Today’s Class
T O U N D E R S TA N D THERE IS A NEED COMBINE
HOW NUTRITION TO DEVELOP NUTRIGENETIC-
INFLUENCES GENE D I E TA RY- BASED ADVICE
EXPRESSION I N T E RV E N T I O N A L AND
S T R AT E G I E S ‘OMIC’BIOMARKER
S
Do you have any question?
Individual Works
Question A Question B
What is the difference In your opinion, how to treat
between Nutrigenomic and people with chronic disease using
Nutrigenetic nutrigenomic approach?
Sierrawood School
Visual Arts
Thank you for joining Today’s
class