Infeksi Parasitik Pada Sistem Ginjal Dan Saluran Kemih Dr. Erwin
Infeksi Parasitik Pada Sistem Ginjal Dan Saluran Kemih Dr. Erwin
Infeksi Parasitik Pada Sistem Ginjal Dan Saluran Kemih Dr. Erwin
Kemih
(1) Different
stages of life cycle
(2) Tendency to
chronicity
parasitism
Direct contact
• Common, e.g schistosoma
Ectopic
• very rare, e.g migrating worm or larvae
Schistosomiasis Trichinosis
Barsoum, 2013
Opisthorchiasis
Trypanosomiasis Candidiasis
Filariasis Babesiosis
Epidemiology of Malaria related Renal disease
• Vector: Anopheles spp
• In Southeast Asia, acute renal failure (ARF) is one of
the most common complications in adults with severe
falciparum malaria.
• The incidence ~15-48% high fatality rate estimated
>70% in untreated patients .
• The availability of renal replacement therapy (RRT) and
appropriate antimalarial chemotherapy has been
shown to reduce case fatality rate as well as enhance
the recovery of renal function
www.uspharmacist.com
Specialized population:
Severely ill (ICU patients) and
HIV infected patients
Biofilms & morphological plasticity: Candida spp
• Uropathogens use different mechanisms for survival in
response to stresses in the bladder (such as starvation
and immune responses).
• By forming biofilms and undergoing morphological
changes, uropathogens can persist and cause recurrent
infections
• Candida spp Candidiasis biofilms associated infection
(4th BSI and 3rd UTI) in the urinary catheter (incl.
Pacemakers, artificial heart valves, voice prostheses, CNS
shunt)
• Specialized populations, e.g ICU patients
Flores-Mireles et al. Nat Rev Microbiol. 2015
HIV and schistosomiasis co-infection in African children - thelancet.com
How to make a correct diagnose?
Brief anamnesis
Laboratory, Radiology or
other supporting
examination
Parasitology Laboratory
Examination
• Correct diagnosis made by findings of
parasite in clinical specimen, in case of
suspected parasitic UTI means that at
least urine sample(s) were sent to our
lab to be examined
Management...
• Species-specific (e.g Malaria anti-malaria,
Schistosomiasis & Filariasis anthelminthic)
• Made a correct diagnosis before starting to
prescribe medication
• By doing a comprehensive anamnesis, physical
examination and supporting examination (e.g
laboratory, radiographic, immunology, pathology)
• In case of suspected parasite infection, in order
to make a correct diagnosis finding the
parasite in clinical sample is obligatory/
mandatory!
conclusion
Urinary Tract Disorders in Parasitic Infections
could be the results of :