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Instrumental Vs Classical Methods (1a)

Classical methods of chemical analysis relied on techniques like precipitation, extraction and distillation to separate analytes, followed by qualitative analysis using color changes or physical properties and quantitative analysis using gravimetric or titrimetric methods. In contrast, instrumental methods employ physical property measurements from instruments like conductivity meters and spectrometers, and use efficient chromatography techniques, to separate and quantitatively analyze inorganic, organic and biochemical analytes with greater sensitivity and over a wider concentration range.

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280 views5 pages

Instrumental Vs Classical Methods (1a)

Classical methods of chemical analysis relied on techniques like precipitation, extraction and distillation to separate analytes, followed by qualitative analysis using color changes or physical properties and quantitative analysis using gravimetric or titrimetric methods. In contrast, instrumental methods employ physical property measurements from instruments like conductivity meters and spectrometers, and use efficient chromatography techniques, to separate and quantitatively analyze inorganic, organic and biochemical analytes with greater sensitivity and over a wider concentration range.

Uploaded by

haditiya dana
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Instrumental vs Classical

Analytical Methods
Classical Methods
Early years of chemistry
 Separation of analytes by precipitation, extraction, or
distillation.
• Qualitative analysis by reaction of analytes with
reagents that yielded products that could be recognized
by their colors, boiling or melting points, solubilities,
optical activities, or refractive indexes.
• Quantitative analysis by gravimetric or by titrimetric
techniques.
Instrumental Methods

• Measurement of physical properties of analytes -


such as conductivity, electrode potential, light
absorption or emission, mass-to-charge ratio, and
fluorescence-began to be employed for quantitative
analysis of inorganic, organic, and biochemical
analytes.
• Efficient chromatographic separation techniques
are used for the separation of components of
complex mixtures.
• Instrumental Methods of analysis (collective name
for newer methods for separation and determination
of chemical species.)
Sensitivity
Ability to discriminate between small differences is
analyte concentration.

calibration sensitivity, S = MC + Sbi

S = measured signal
c = concentration of analyte
Sbi = instrument signal for a blank
M = slope of the straight line
Applicable Concentration
Range

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