Benarkah Kecanduan Narkoba Adalah Penyakit Otak?: Tsaradiksi @
Benarkah Kecanduan Narkoba Adalah Penyakit Otak?: Tsaradiksi @
Benarkah Kecanduan Narkoba Adalah Penyakit Otak?: Tsaradiksi @
tsaradiksi@hotmail.com
Riset mengenai Adiksi Napza
telah lebih dari setengah abad.
Riset mengenai Otak lebih dari
seperempat abad.
ISI PRESENTASI
• MANUSIA DAN OTAK
• HUBUNGAN PERILAKU DAN OTAK
• NARKOBA MASUK KEDALAM TUBUH
• NARKOBA MASUK KEDALAM OTAK
• PERUBAHAN PERILAKU AKIBAT
DISFUNGSI OTAK
OTAK BAGIAN TUBUH YANG
PALING PENTING
APA SAJA FUNGSI DARI
OTAK?
www.drugabuse.gov
PET Image
Apa yang terjadi
didalam otak
pecandu?
CT (roentgen-ray Computed
Tomography)
Environmental
Contribution:
PHARMACOLOGICAL
• stress RESPONSE
• drug availability
• physical abuse
• sexual abuse
Repeated
• peer group
Use
Developmental
Adolescence
ADDICTION
Evidence from adoption and twin studies demonstrate that addiction,
like other chronic diseases, is a heritable disorder and that genes play
a role in vulnerability to addiction. Genes can also play a role in
protecting individuals from addiction.
As with all complex diseases, environmental risk and protective factors
interact with genetics to determine the course and outcome of disease.
Numerous compounds that bind selectively to
neuroreceptors of interest in biological psychiatry have
been radiolabeled with 11C or 18F. Radioligands that
bind to dopamine receptors (D1,D2, reuptake
transporter), serotonin receptors (5HT1A, 5HT2A,
reuptake transporter) opioid receptors (mu) and other
sites have been used successfully in studies with human
subjects. Studies have been performed examining the
state of these receptors in patients compared to healthy
controls in schizophrenia, substance abuse,
mood disorders and other psychiatric
conditions.
Imaging studies have shown evidence of tissue malfunction in the
brains of those with addiction, and in the hearts of people with heart
disease.
Sources: From the Laboratories of Drs. N. Volkow and H. Schelbert
Addiction is a developmental
states in adolescence and
childhood
Relapse is Common in Addiction and Other
Complex Chronic Diseases
Relapse Rates Are Similar for Addiction and Other Chronic Illnesses
MDMA user