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    Applied Biology (PERSONALIZED MEDICINE)

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    HAZEL LEELA A P RICHARD
    Personalized medicine increases patient safety, reduces adverse drug reactions, improves compliance and quality of life, reduces healthcare costs, revives failed drugs, and improves disease detection and prevention by customizing treatment to the individual patient based on their genetics, biomarkers, and disease characteristics. It prescribes more effective drugs and avoids drugs with side effects.

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    Applied Biology (PERSONALIZED MEDICINE)

    Uploaded by

    HAZEL LEELA A P RICHARD
    106 views9 pages
    Personalized medicine increases patient safety, reduces adverse drug reactions, improves compliance and quality of life, reduces healthcare costs, revives failed drugs, and improves disease detection and prevention by customizing treatment to the individual patient based on their genetics, biomarkers, and disease characteristics. It prescribes more effective drugs and avoids drugs with side effects.

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    Personalized medicine increases patient safety, reduces adverse drug reactions, improves compliance and quality of life, reduces healthcare costs, revives failed drugs, and improves disease detection and prevention by customizing treatment to the individual patient based on their genetics, biomarkers, and disease characteristics. It prescribes more effective drugs and avoids drugs with side effects.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    106 views9 pages

    Applied Biology (PERSONALIZED MEDICINE)

    Uploaded by

    HAZEL LEELA A P RICHARD
    Personalized medicine increases patient safety, reduces adverse drug reactions, improves compliance and quality of life, reduces healthcare costs, revives failed drugs, and improves disease detection and prevention by customizing treatment to the individual patient based on their genetics, biomarkers, and disease characteristics. It prescribes more effective drugs and avoids drugs with side effects.

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    Benefits of personalized medicine

    Increase patient
    Increases safety and Reduce the time, cost,
    compliance and
    reduces adverse drug and failure rate of
    adherence to
    reaction. clinical trials.
    treatment.

    Reduces the overall Customsize disease-


    Improve quality of life.
    cost of healthcare. prevention drugs.

    Prescribe more
    effective drugs and
    Revive drugs that Improve disease
    avoid prescribing
    failed in clinical trials . detection.
    drugs with side
    effects.
    Personalized medicine vs. Traditional
    medicine
    Personalized Medicine Traditional Medicine

    Non invasive and captures more Invasive and does not capture the
    characteristic of a disease . heterogeneity of the disease.

    Individualized and genetically targeted Trial and error to find the right
    medicine. medication.

    Prevents adverse effects, predicts dosing Large percentage of patients do not


    and improves compliance. benefit.

    Recruit patients most likely to respond in One-size-fits-all approach in clinical


    clinical trials. traits.
    Current perspectives on personalized
    medicine

    • Healthcare delivery is mainly focused on “sick care”.


    • Lack of coordination and fragmentation on this field.
    • Cost growing and unsustainable.
    • Pressures of expensive new technologies.
    • Inefficient information about the drugs and biomarkers
    used.
    • Complicated framework.
    Future perspectives on personalized
    medicine

    • Transformational changes in the medicine field.


    • Convergence of the molecular biology, genetics,
    advanced technology and bioinformatics.
    • Developments in science and technology.
    • Reclassification of disease.
    • Integrated and coordinated framework.
    • High understanding on genomics and their uses.
    Goals of personalized medicine

    • Identify genetic difference between people


    towards drug response.
    • Develop genetic tests that predict an individual’s
    response towards a specific drug.
    • Tailor medical treatment to the individual by :
    - Increasing the effectiveness
    - Minimize adverse side effects.
    Types of personalized medicine,drugs and
    treatments
    DRUGS BIOMARKER/TEST USED TO TREAT
    Herceptin HER-2/neu receptor Breast cancer – for
    treatment of patients with
    metastatic breast cancer
    whose tumors over express
    the HER-2 protein and who
    have received one or more
    chemotherapy regimens
    for their disease.

    Warfarin CYP2C9 Cardiovascular disease –


    Increased bleeding risk for
    patients carrying either
    CYP2C9*2 or CYP2C9*3
    alleles.

    Atorvastatin LDLR Cardiovascular disease


    Heparin
    DRUGS BIOMARKER USED TO TREAT
    Tamoxifen HOXB13,IL17BR Breast cancer
    Tagretol HLA-B*1502 Epilepsy and bipolar
    disorder

    Ziagen HLA-B*5701 HIV


    Statins Phyzio Type SINM Cardiovascular disease

    Camptosar UGT1A1 Colon cancer


    Drugs metabolized by Amplichip Multiple disease – Used
    CYP P450 to determine treatment
    choice and individualizing
    treatment dose for
    therapeutics.
    Immunosuppressive AlloMap Heart transplantation-
    drugs Monitors patients
    immune towards heart
    transplant.
    DRUGS BIOMARKER USED TO TREAT

    Rifampin NAT Toxic reactions

    Rituximab PGx PredictTM Non-Hodgkin’s


    lymphoma

    Celebrex CYP2C9 Pain

    Gleevec c-KIT Stomach cancer//


    gastrointestinal stromal
    tumors

    Risperdale PhyzioType Psychiatric disorders

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