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Matlab Toolbox For Inter-Subject Correlation Analysis

This document provides an overview of a Matlab toolbox for analyzing inter-subject correlation (ISC) in fMRI data collected during natural stimuli experiments. The toolbox allows users to calculate voxel-wise correlation matrices across subjects and perform permutation testing to identify significantly correlated voxels. It produces ISC maps across the whole session or within time windows and frequency bands. The toolbox has a graphical interface and allows fast visualization and access of results. It requires preprocessed fMRI data and is available for free online.

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Emmanuel Goldstein
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155 views8 pages

Matlab Toolbox For Inter-Subject Correlation Analysis

This document provides an overview of a Matlab toolbox for analyzing inter-subject correlation (ISC) in fMRI data collected during natural stimuli experiments. The toolbox allows users to calculate voxel-wise correlation matrices across subjects and perform permutation testing to identify significantly correlated voxels. It produces ISC maps across the whole session or within time windows and frequency bands. The toolbox has a graphical interface and allows fast visualization and access of results. It requires preprocessed fMRI data and is available for free online.

Uploaded by

Emmanuel Goldstein
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPT, PDF, TXT or read online on Scribd
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Matlab Toolbox for Inter-Subject

Correlation Analysis

Overview
ISC toolbox: Background
• fMRI studies utilizing natural stimuli such as movies, music,
and video games are getting more and more popular (see,
for example [1])
• Because these stimuli are extremely complex, modeling
hemodynamic responses using the GLM becomes
inconvenient
• Inter-subject correlation (ISC) analysis does not require
modeling of the hemodynamic response and has been
succesfully applied to investigate natural stimulus fMRI
data sets [2-4]
• Comprehensive and easy-to-use toolbox to study the brain
based on ISCs would be beneficial
ISC toolbox: Overview
• Runs on Matlab
• Reads in preprocessed and registered fMRI data either in
mat- or nifti-format
• The best way to avoid compatibility problems is to
preprocess and register your data with the FSL
• Graphical User Interface (GUI) developed for:
-setting-up your analysis parameters correctly
-easy and quick visualization of the results
• Access of the results is fast and easy also directly using
command line options
• The use of Matlab’s memory mapping feature avoids many
problems associated with large data sets (in terms of both
memory and speed)
ISC toolbox: Features
• Voxel-wise ISC analysis across n subjects:
-calculation of voxel-wise n by n correlation matrices
- permutation based inference on the average of the n(n-1)/2
subject-pairwise correlation coefficients for each voxel [3]

• The above analysis can be performed:


-across the whole scanning session
-within the specified time-windows to obtain time-varying ISC
maps
-within distinct frequency-subbands to obtain frequency-
specific ISC maps [3]
ISC toolbox: More features
• In addition to mean ISC maps, one can
investigate other maps including:
-the corresponding median, lower quartile, upper
quartile and standard deviation maps
-t statistical maps [4]
-contrast maps to compare ISC between frequency
bands [3]
• More features will be added to the
toolbox in the near future
ISC toolbox: Requirements
• The maximum amount of memory required to
run group ISC analysis is determined by the size
of the fMRI data of a SINGLE subject (consider
also memory limitation of Matlab)
• To run analysis in feasible time, we highly
recommend grid computation unless very
powerful computer is available.
• After running the analysis, quick visualization and
command line access of the results should be
possible using your personal laptop.
ISC toolbox: Availability

• Free toolbox is available via the following link:


http://sites.google.com/site/frequencyspecificisc

• For any questions, contact:


Jukka-pekka.kauppi {at} tut.fi
References

[1] H. Spiers and E. Maguire, "Decoding human brain activity during


real-world experiences," Trends in Cognitive Sciences, vol. 11, no.
8, pp. 356-365, August 2007.
[2] Hasson et al: “Intersubject synchronization of cortical activity
during natural vision,” Science, vol. 303, no. 5664, pp. 1634–1640,
March 2004.
[3] Kauppi et al: ”Inter-subject correlation of brain hemodynamic
responses during watching a movie: localization in space and
frequency," Frontiers in Neuroinformatics, March 2010.
[4] Wilson et al: “Beyond superior temporal cortex: Intersubject
correlations in narrative speech comprehension,” Cereb. Cortex,
vol. 18, no. 1, pp. 230–242, January 2008.

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