Ventricular Septal Defect

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 The ventricular septum form before

8th` week of fetal life and require


downward growth from endocardial
cushion and the bulbar ridge
separating PA &Aorta.
 Failure of these structures to grow
correctly will result VSD.
 RISK FACTORS
 Genetic Factors , Radiation Exposure,
Drugs Like Teratogens, Antenatal
Effects, Chromosomal Disorders
 TYPES OF VSD
A. PER MEMBRANOUS VSD : These are the most
common type of ventricular septal defects.
They involve the membranous part of
ventricular septum which lies in the outflow
tract of the left ventricle immediately beneath
the aortic valve. They usually extend into
muscular, inlet or outlet portion of ventricular
septum.
B. Inlet VSD : These VSD account for 5 to 8 % of
all the VSD's. They are located posteriorly and
inferior to perimembranous portion of
ventricular septum.
C. Subarterial VSD or Doubly committed VSD or
Subpulmonary VSD : These VSD account for 5
to 7 % of all the VSD’s. They are located just
beneath the pulmonary valve.
 D. Muscular VSD : These VSD account for
5 to 20 % of all the VSD’s and are further
sub classified depending on their location
in the muscular septum. i) Central :
Located in the mid-muscular part of the
ventricular septum with multiple apparent
channels on right ventricular side and
single defect on the left ventricular side. ii)
Apical : Located in the apical part of the
ventricular septum with multiple apparent
channels on right ventricular side and
single defect on the left ventricular side.
iii) Swiss Cheese : Multiple muscular
defects in the ventricular septum.
 CLINICAL MANIFESTATION
Small VSD may be asymptomatic
Pan systolic murmur
Moderate breathing difficulty -slow to gain
weight - Respiratory infection - Sign of LV
failure - Mid systolic murmur
Large VSD
Hepatomegaly &oliguria
Systolic murmur with thrill
Failure to thrive
Biventricular hypertrophy and CCF
CLINICAL MANIFESTATIONS: •Feeding difficulty
•Poor Weight Gain •Failure to cry •Increased
sweating •Palpitation •Dyspnoea •Cyanosis
 DIAGNOSTIC EVALUATION
History of illness
Physical Examination
Chest x-ray(cardiomegaly, enlarged LA& LV,
PA, increased Pulmonary vascular
marking, Pulmonary Edema)
ECG(Extreme left axis is characteristics,
biventricular hypertrophy)
ECO(Chamber size and pressures)
Two dimensional echo cardiogram with
Doppler study
Cardiac catheter o2 content, PA pressure,
size and no of defects.
 PROGNOSIS
Risk depends on the location of the defect , the
number of defects, and the presence of other
associated cardiac defects. Single membranous
defects are associated with low mortality (<2%)
multiple muscular defects can occur a higher
risk.
COMPLICATIONS
Arrhythmias
Right ventricular failure
Pulmonary complication-pneumonia, enlarged LA,
left lobe collapsed
Residual VSD
Pulmonary hypertension
Pulmonary stenosis
Failure to thrive

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