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Sample Size Estimation

This document discusses sample size estimation for descriptive and comparative research studies. It provides formulas and guidelines for determining sample sizes based on confidence intervals for descriptive studies and power calculations for comparative studies. Specific formulas are given for comparing two independent means, two dependent means, and two proportions. The key factors that determine sample size are the desired confidence level, statistical power, estimated standard deviation or effect size of the variables, and magnitude of difference being tested. Adjustments may be needed for dropouts, missing data, and clustered data.

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18TPCV012 HARSHA BABU E
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114 views14 pages

Sample Size Estimation

This document discusses sample size estimation for descriptive and comparative research studies. It provides formulas and guidelines for determining sample sizes based on confidence intervals for descriptive studies and power calculations for comparative studies. Specific formulas are given for comparing two independent means, two dependent means, and two proportions. The key factors that determine sample size are the desired confidence level, statistical power, estimated standard deviation or effect size of the variables, and magnitude of difference being tested. Adjustments may be needed for dropouts, missing data, and clustered data.

Uploaded by

18TPCV012 HARSHA BABU E
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Sample Size Estimation

RESARCH METHODOLOGY

E.HARSHA BABU
18TPCV012
Objectives
• To understand the issues related to sample size and to
be able to estimate sample size needed for various
research design situations
• Estimate the required sample size based on power
calculations (for comparative study designs)
• Estimate the required sample size based on confidence
intervals (for descriptive study designs)
• Understand how sample size is related to statistical
analysis
• Learn the limitations of sample size estimation
• Find resources (textbook and internet) to assist with
sample size estimation
Is the study descriptive or is the study
comparative?
• Descriptive studies include surveys to assess prevalence, needs
assessments, chart reviews, etc. that have as a main aim the
estimation of rates, proportions and means in a population with a
secondary aim being to examine whether the rates are related to
demographic variables (i.e. a correlational analysis). For example, a
survey may be undertaken to assess the extent of doughnut
consumption in Belltown. The main results to be reported might be
the percentage of residents who consume doughnuts on a daily basis,
or the mean number of doughnuts consumed by a resident per week.
Follow-up analysis might examine whether the consumption rates
depend on the sex or age of the resident. Sample size determination
for descriptive studies is based on confidence intervals; that is, the
level of precision required in providing estimates of the rates,
proportions and means.
Sample Size Estimation for Descriptive
Studies
Sample Size Estimation
The basic formulas require the four components
discussed above:
• an acceptable alpha
• an acceptable power (or beta)
• the population standard deviation of the
outcome variables, and
• the magnitude of the clinical difference of
interest.
We will consider the following
situations
• For Measurement Outcome Variables
– Comparison of two independent means
– Comparison of two dependent means
• For Categorical Outcome variables
– Comparison of two proportions
• For Complicated Designs
– Correlation and Regression
– Multiple Regression
– Logistic Regression
– Factor Analysis
– Rank Tests
Comparison of two means
(independent):
• We begin with a basic formula for sample size.
Start with two groups, a continuous
measurement endpoint, a two-sided
alternative, normal distributions with the
same variances and equal sample sizes. The
basic formula is:
• Δ can be thought of as the standardized
difference between means, measured in units
of the standard deviation. The magnitude of
clinical difference of interest and the standard
deviation are combined into a single quantity.
And this quantity has a famous name – it is
known as the Effect Size (ES). As a guideline,
Jacob Cohen classified effect sizes as small,
moderate, and large (0.2, 0.5, and 0.8 for two-
group comparisons); you can use these as a
starting point.
• In the one-sample case, the numerator is 8,
instead of 16; that is, N = 8 / Δ2. This situation
occurs when a single sample is being
compared with an external population value
(i.e. a target). Note that the sample size for a
one-sample case is one-half the sample size
for each sample in a two-sample case. But
since there are two samples, the total in the
two-sample case will therefore be four times
that of the one-sample case.
Comparison of two proportions:

For example, if p0 = .30 and p1 = .10, then p = .20,


so the required sample size per group is 64.

As with the comparison of two means, the


multiplier of 16 can be changed. The same values
as in the previous table apply here too.
CONCLUSION
• Remember to plan for dropouts and for
subjects with missing data.
• Make sure you know whether the formulas
you used are for equal sample sizes.
• For paired measurement scale (i.e.
continuous) data, use the standard deviation
of the change scores, not of the variable itself.
• Be aware of clustered data and the unit of
analysis.
THANK YOU

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