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Immune Response: Dewi Wulandari

The immune system protects the body from pathogens and has powerful defense mechanisms to recognize and eliminate invaders. It consists of primary lymphoid organs like the thymus and bone marrow, secondary lymphoid organs like lymph nodes, and immune cells. The innate immune response is the first line of defense and includes anatomical barriers, humoral factors, commensal microbes, and cellular components like macrophages and dendritic cells. Upon activation, it causes inflammation and phagocytosis of pathogens, which then activates the adaptive immune response of B and T lymphocytes and antibody production.

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22 views30 pages

Immune Response: Dewi Wulandari

The immune system protects the body from pathogens and has powerful defense mechanisms to recognize and eliminate invaders. It consists of primary lymphoid organs like the thymus and bone marrow, secondary lymphoid organs like lymph nodes, and immune cells. The innate immune response is the first line of defense and includes anatomical barriers, humoral factors, commensal microbes, and cellular components like macrophages and dendritic cells. Upon activation, it causes inflammation and phagocytosis of pathogens, which then activates the adaptive immune response of B and T lymphocytes and antibody production.

Uploaded by

El Fatih
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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IMMUNE RESPONSE

DEWI WULANDARI
CLINICAL PATHOLOGY DEPARTMENT
FACULTY OF MEDICINE, UNIVERSITY OF INDONESIA
CIPTO MANGUNKUSUMO HOSPITAL
JAKARTA
IMMUNE SYSTEM
• The immune system is fundamental to survival, as it
protects the body from pathogens that cause
disease.

• Properties of immune system:


• Powerful defense mechanisms to recognize and
eliminate potential invaders
• differentiate between the individual’s own cells and
those of harmful invading organisms
Organs of Immune system

1. Primary lymphoid
organ
(Thymus & Bone
marrow)
2. Secondary
Lymphoid organ
(lymph nodes)
COMPONENT OF IMMUNE
SYSTEM
IMMUNE CELLS
IMMUNE RESPONSE
Innate vs adaptive immune response
INNATE IMMUNE RESPONSE
Component of Innate Immune System
Anatomical & Mechanical Barriers
- Skin and mucosal lining
- Mechanical reflex

Humoral components
- Low pH
- Proteolytic enzymes
- Complement

Biological components
- Commensal microbial
Cellular components
- Macrophages
- Dendritic cells
- NK cells
INNATE IMMUNE RESPONSE
INNATE IMMUNE RESPONSE
HOW INNATE IMMUNE
SISTEM RESPONSE TO
PATHOGENS

Activation of adaptive immune system

Inflammation
Phagocytosis
PHAGOCYTOSIS

3 PROCESSES OF PHAGOCYTOSIS:
1. Recognition
2. Engulfment
3. Killing
INFLAMMATION RESPONSE
ACTIVATION OF ADAPTIVE
IMMUNE RESPONSE
ADAPTIVE IMMUNE RESPONSE
Component of Innate Immune
System
Humoral components
- Lymphocyte B & antibody

Cellular components
- Lymphocyte T:
- T helper
- T cytotoxic
ADAPTIVE IMMUNE RESPONSE
ADAPTIVE
IMMUNE
RESPONSE
SPECIFIC IMMUNITY
ANTIBODY SYNTHESIS
ROLE OF ANTIBODY FOR
EFFECTOR SYSTEMS
HOW DC INITIATE ADAPTIVE
IMMUNE RESPONSE
T CELL DEVELOPMENT
T CELL ACTIVATIONS
+
CD8 T CELL ACTIVATIONS
+
CD4 T CELL ACTIVATIONS
INFLAMMATION
HOW IMMUNE CELLS
COMMUNICATE
IMMUNE RESPONSE

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