Scribd Logo
Upload

Welcome to Scribd!

  • 25 views

    Obat Nyeri Sendi: Osteoarthritis Rheumatoid Arthritis Gout Arthritis

    Uploaded by

    Ajeng Salsabila Pawestri
    This document discusses treatments for rheumatoid arthritis (RA) and osteoarthritis. It outlines the goals of relieving pain, reducing inflammation, and preventing joint damage. Treatment approaches include lifestyle modifications, physical therapy, medications, and surgery. Medications include NSAIDs, DMARDs (disease-modifying antirheumatic drugs), biologics, and corticosteroids. DMARDs such as methotrexate can slow disease progression and reduce symptoms. Biologics that target TNF-alpha may provide greater efficacy than non-biological DMARDs. The document also discusses gout arthritis and treatments for hyperuricemia and acute gout attacks.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd

    Obat Nyeri Sendi: Osteoarthritis Rheumatoid Arthritis Gout Arthritis

    Uploaded by

    Ajeng Salsabila Pawestri
    25 views41 pages
    This document discusses treatments for rheumatoid arthritis (RA) and osteoarthritis. It outlines the goals of relieving pain, reducing inflammation, and preventing joint damage. Treatment approaches include lifestyle modifications, physical therapy, medications, and surgery. Medications include NSAIDs, DMARDs (disease-modifying antirheumatic drugs), biologics, and corticosteroids. DMARDs such as methotrexate can slow disease progression and reduce symptoms. Biologics that target TNF-alpha may provide greater efficacy than non-biological DMARDs. The document also discusses gout arthritis and treatments for hyperuricemia and acute gout attacks.

    Original Description:

    obat anti nyeri pada sendi

    Original Title

    ANTINYERI SENDI, 2019

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document discusses treatments for rheumatoid arthritis (RA) and osteoarthritis. It outlines the goals of relieving pain, reducing inflammation, and preventing joint damage. Treatment approaches include lifestyle modifications, physical therapy, medications, and surgery. Medications include NSAIDs, DMARDs (disease-modifying antirheumatic drugs), biologics, and corticosteroids. DMARDs such as methotrexate can slow disease progression and reduce symptoms. Biologics that target TNF-alpha may provide greater efficacy than non-biological DMARDs. The document also discusses gout arthritis and treatments for hyperuricemia and acute gout attacks.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    25 views41 pages

    Obat Nyeri Sendi: Osteoarthritis Rheumatoid Arthritis Gout Arthritis

    Uploaded by

    Ajeng Salsabila Pawestri
    This document discusses treatments for rheumatoid arthritis (RA) and osteoarthritis. It outlines the goals of relieving pain, reducing inflammation, and preventing joint damage. Treatment approaches include lifestyle modifications, physical therapy, medications, and surgery. Medications include NSAIDs, DMARDs (disease-modifying antirheumatic drugs), biologics, and corticosteroids. DMARDs such as methotrexate can slow disease progression and reduce symptoms. Biologics that target TNF-alpha may provide greater efficacy than non-biological DMARDs. The document also discusses gout arthritis and treatments for hyperuricemia and acute gout attacks.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 41

    OBAT NYERI SENDI

    OSTEOARTHRITIS
    RHEUMATOID ARTHRITIS
    GOUT ARTHRITIS
    osteoarthritis
    American College of Rheumatology2012
    Recommendations
    RHEMATOID ARTHRITIS
    Joint Destruction

    Modified from Immunex Corporation


    Treatment Goals Treatment Approaches
    • Relieve pain • Lifestyle modifications

    • Reduce inflammation • Rest

    • Prevent/slow joint damage • Physical and occupational


    therapy
    • Improve functioning and quality
    of life • Medications

    • Surgery
    Traditional pyramid for treatment of RA

    Assumptions:-
    Exper 1) RA relatively benign disease
    imental 2) NSAIDs less toxic than DMARDs
    therapy
    High dose
    corticosteroids

    Cyclophosphamide

    Methotrexate, azathiaprine

    Hydroxychloroquine Gold
    Sulphasalazine salts

    NSAIDs Low dose prednisone

    Patient Physical Occupational High dose


    education therapy therapy salicylates
    Drug Treatments

    • Nonsteroidal anti-inflammatory drugs (NSAIDs)

    • Disease-modifying antirheumatic drugs (DMARDs)

    • Biologic response modifiers

    • Corticosteroids
    Current therapies:
    NSAIDs (COX2-inhibitor) & Corticosteroid
    NSAID- anti-inflammatory & immunosuppressive effcts.
    Corticosteroids are primarily used in short courses for flres or during the
    initiation of DMARD therapy
    (GI ulceration & Bleeding. Not DMARD)

    Non-biological DMARDs
    methotrexate, leflnomide, hydroxychloroquine, sulfasalazine, and
    minocycline
    → relieving pain and inhibiting the progression of disease
    Efficacy (refractory), Safety – Myelosuppression, Hepatic toxicity

    Biological DMARDs
    toclizumab, adalimumab, infliximab, golimumab and abatacept
    →alter a specific step in the pathogenesis of the inflmmatory
    response, eg TNF
    more efficacy, lesser side effects, higher cost as compared to non-
    biological DMARDs,
    Safety – TB, Op infection, CHF, Demyelinating Disease, Lymphoma
    NSAID dan
    Kortikosteroid
    Non Biological DMARDs

    • FD : menekan
    sistem kekebalan
    tubuh memperlambat
    laju kerusakan
    jaringan &
    progressifitas
    penyakit.
    Biological DMARDs
    Promising Theraphy
    Advantages of DMARDs

    • Slow disease progression


    • Improve functional disability
    • Decrease pain
    • Interfere with inflammatory processes
    • Retard development of joint erosions
    Selection of an Initial DMARD
    Agent Time to benefit Potential Toxicities to monitor
    Azathioprine 2-3 months toxicity
    Moderate Myelosuppression,
    hepatotoxicity,
    Cyclosporin 4-8 weeks lymphoproliferative
    Gold, oral 4-6 months High
    Low Renal, hyperuricemia
    Gold, parenteral 3-6 months
    Moderate Myelosuppression, rash,
    Hydroxychloroquine 2-4 months proteinuria,
    Leflunomide 4-8 weeks gastrointestinal
    Low Myelosuppression, rash
    Methotrexate 1-3 months Low proteinuria
    Macular damage
    D-Penicillamine 3-6 months Moderate Hepatotoxicity,
    gastrointestinal
    Sulfasalazine 1-3 months Hepatotoxicity,
    High pulmonary,
    myelosuppression
    GOUT ARTHRITIS
    Tata Laksana
    Hiperurosemia dan Gout
    Target kerja Obat Anti-Hiperurisemia
    URICOSURIC DRUG
    Antiinflamasi pada Gout
    Colchicine
    MANAGEMENT OF ACUTE GOUT
    MANAGEMENT OF PROPHYLAXIS GOUT

    You might also like