Submitted By: Anthony B. Taquiqui BSN - A314 Submitted To: Mrs Gretel Viray RN, MAN

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Submitted by: Anthony B.

Taquiqui
BSN – A314

Submitted to: Mrs Gretel Viray RN, MAN


Purpura is the name given to the discoloration of the skin or mucous
membranes due to hemorrhage from small blood vessels.

Petechiaeare small, purpuric lesions up to 2mm across


Ecchymoses or bruises are larger extravasations of blood.

Extravagated blood usually breaks down and changes color over a


few weeks from purple, orange, brown and even blue and green.
•Thrombocytopaenic purpura Primary (idiopathic) thrombocytopaenic purpura –
destruction of platelets due to unknown cause
Platelet disorders
•Secondary thrombocytopaenic purpura – caused by external or internal factors, e.g.
drugs, infections, certain diseases

•Non-thrombocytopaenic purpura – blood may leak as a result of: Damage to small blood
vessels
Vascular disorders
•Increase in the intraluminar pressure
•Deficient vascular support, as in aged or sun damaged skin (senile purpura)

•Disseminated intravascular coagulation – clinical picture varies from a severe and


rapidly fatal disorder (purpura fulminans) to a relatively minor disorder
•Heparin induced thrombocytopaenia– purpura and necrosis due to anti-platelet
Coagulation disorders
antibodies inducing platelet plugs that block blood vessels
•Warfarin induced necrosis – purpura and necrosis due to blood clots related to relative
protein C deficiency early in treatment
The signs and symptoms of purpura vary depending on the type of
purpura. The following broad generalizations may be made.
Petechiae are usually present in thrombocytopaenic purpura.
There may be some external bleeding and bruising.

Coagulation defects usually present as large ecchymoses and


external bleeding. Petechiae do not feature.

Lesions of blood vessels cause persistent and localized purpura


with an erythematous inflammatory component. This may be
palpable. Ecchymoses and external bleeding are uncommon.
Removal of the Spleen (Splenectomy)
If necessary, the spleen will be removed surgically. This organ is located in the upper left abdomen. The spleen
is about the size of a golf ball in children and a baseball in adults.
The spleen makes antibodies (proteins) that help fight infection. In ITP, these antibodies destroy platelets.
If ITP hasn't responded to steroids, removing the spleen will reduce the destruction of platelets. However, it
also may make you more likely to get certain infections. Before you have the surgery, your doctor may give you
vaccines to help prevent these infections.
Other Treatments
Platelet Transfusions
Some people with ITP who have severe bleeding may need to have platelet transfusions and be hospitalized.
Some people will need a platelet transfusion before having surgery.
For a platelet transfusion, donor platelets from a blood bank are injected into the recipient's bloodstream. This
increases the platelet count for a short time.
Treating Infections
Some infections can briefly lower a person's platelet count. If a person who has ITP has an infection that can
lower his or her platelet count, treating the infection may help increase the platelet count and reduce bleeding
problems.
Stopping Medicines
If a person who has ITP is taking medicine that can lower his or her platelet count or cause bleeding, stopping
the medicine can sometimes help increase the platelet count or prevent bleeding.
For example, aspirin and ibuprofen are common medicines that increase the chance of bleeding. If you have
ITP, your doctor may suggest that you avoid these medicines.

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