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PET Scan

The document discusses hybrid imaging techniques that combine nuclear medicine imaging methods like PET and SPECT with computed tomography (CT). It focuses on PET/CT and describes how radiotracers like 18F-FDG are used with PET to detect increased glucose metabolism in cancerous and inflamed tissues. The document outlines the imaging process and provides examples of how 18F-FDG PET/CT can be used to stage and monitor response to treatment for various cancer types.

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AmineSlama
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140 views30 pages

PET Scan

The document discusses hybrid imaging techniques that combine nuclear medicine imaging methods like PET and SPECT with computed tomography (CT). It focuses on PET/CT and describes how radiotracers like 18F-FDG are used with PET to detect increased glucose metabolism in cancerous and inflamed tissues. The document outlines the imaging process and provides examples of how 18F-FDG PET/CT can be used to stage and monitor response to treatment for various cancer types.

Uploaded by

AmineSlama
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd
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HYBRID IMAGING

HYBRID IMAGING
 Combination
 Nuclear medicine
 Radiology
 PET/CT
 Positron emission tomography
 Computed tomography
 SPECT/CT
 Single photon emission tomography
 Computed tomography
 PET/MRI
Beta plus decay


Nucleus reach of protons
Proton is transformed to neutron 18F
n g 511 keV
 Emission of positron and neutrino
 Periodical table shift to the left by one site
 18F to18O
 Positron is living only few ms
 Annihilation of the matter
 Interaction of electron and positron e+
 Gamma rays 180
 2 quanta E – 511 keV e-
 Unique energy
 Angle180o

511 keV g
PET/CT scanner
Radiopharmaceuticals
 18F halftime110 min
 18FDG – fluorodeoxyglucose
 18FLT – fluorothymidine
 Na18F
 18F-Estradiol, 18F-methionin, 18F-DOPA, 18F-cholin
 68Ga halftime 68 min
 DOTA derivates
 somatostatine analoga
 11C halftime 20 min
 11C-acetate, 11C-cholin
 13N (9 min), 15O (123 s), 82Rb (78 s)
Imaging technique
 Application of radiofarmaka
 Oral preparation
 1000 ml 2,5% manitol
 CT data acquisition
 PET data acquisition
 7 positions per 3 min
Oral preparation
2,5% mannitol
Postprocessing fusion CT + PET

Multiple colorectal cancer


18F-fluorodeoxyglucose

plasma cell

glucose glucose glucose-6-P


glycolysis

18F-FDG 18F-FDG 18F-FDG-6-P

transport phosphorylation glycolysis


18FDG-PET/CT

 Increased uptake
 Tumorous tissues with increased glycolytic activity
 Inflammatory reaction
 Physiological uptake
 brain
 Brown fatty tissue
 Stripped muscles
 Kidneys
 Sallivary glands
staging
 Bronchogenic carcinoma
 Head and neck tumours
 Lymfoma
 Melanoblastoma
BRCA
BRCA
Cerebral lymphoma
Hodgkin disease
Therapy strategy
Sarcoma tendinis Achill. Leiomyosarkoma Synovial sarcoma
Restaging
 Therapy response effect
 Definitive
 In the middle between cycles
Oropharyngeal cancer

18 months after
Early after surgery 3 months later
Cervical cancer

myom
myom
Ca
Ca

Before th After th
Grading
 the assesment of the biologic activity
 More dedifferenciated – higher FDG uptake
Low-grade astrocytoma
Anaplastic oligodendroglioma
Fever of unknown origin

M. Hodgkin
Blastic turnover of the osteomyelofibrosis
Microscopic polyarteritis
18F-fluorothymidine

 replication DNA = cellular proliferation


 Fast dividing cells
 Tumors
 Bone marrow
 Germinative zones of lymph nodes
 Therapy monitoring – RT, CHT
indications
18F-natriumfluoride

 Bone turnover
 fluoroapatite
 Osteoblastic activity
 Osteoplastic bone metastases
 Ca prostate
 Ca breast
 Ca lungs

 Bony tumors
Indications

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