Protein Synthesis: With Thanks To Jenny P

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Protein

Synthesis

With thanks to Jenny P


DNA is a very long molecule that looks like a twisted ladder.

It is made up of 4 different subunits called nucleotides which can


be arranged in any order
The bases are complementary
• DNA has two strands.

• The strands are stuck together by the


complementary bases.

• Adenine to Thymine A-T


• Cytosine to Guanine C-G
It is the Sequence of bases that act like a code

The sequence (order) of bases tells the cell


what proteins to make.

The sequence of bases dictates the sequence


of amino acids, which determines the shape
of a protein.

If the protein is the wrong shape it will not


work properly (it may work differently)

So if the sequence in the DNA is wrong it may


result in a genetic disease
Sickle cell anaemia is caused by
one change in the DNA base code
It is a triplet code.
It takes 3 bases to
code for one amino
acid
Each triplet codes for a different amino acid.
Protein Synthesis takes
place in 2 stages

DNA carries the code for every protein that can be


made by a cell.

A gene is a length of DNA which codes for a particular


protein
Transcription 1
(making a messenger RNA copy of
DNA)

•Part of the DNA molecule (the gene) unzips


•An RNA copy is produced, by matching
complementary bases
Transcription 2

•The mRNA copy is made with the help


of RNA polymerase.
Complementary base pairing
DNA Base Complementary RNA
Base
G C
C G
A U
T A
The m-RNA leaves the nucleus
through a nuclear pore
Nuclear
membrane

RNA
leaving
the
nucleus
RNA in the
cytoplasm
Translation
• The m-RNA goes to the Ribosomes in the
cytoplasm E
F

B
D
C
The ribosomes read the code and
join the amino acids together
Transfer RNA brings the correct
amino acid
Translation - animation
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