Kof 2a Substitution
Kof 2a Substitution
Kof 2a Substitution
a second-order reaction
Three Experimental Evidences Support an SN2
Reaction Mechanism
UNLIKE
more bonding
little bonding
If the reaction is carried out in the gas phase, the
stronger bases are the best nucleophiles, but, if a
protic solvent is used
The Effect of Solvent on Nucleophilicity
Cl Br
R
C C
H H
X
X Nu
Nu
X + Br-
Br
Some Biological Methylating Reagents