Microneedles A Transdermal Drug Delivery System

Microneedles In
Transdermal Drug Delivery
Presented By:
Jayalekshmi .L. Christin Stanley
Meera Elizabeth Siby Sneha John
Under the guidance of

Mrs. Athulya Raj
Assistant Professor
Department of Pharmacy Practice
1
Need Of Microneedles…..?
In elderly people and children who have the fear of painful injections …..!
“MICRONEEDLES” are the best alternative ….
For transdermal drug delivery…..
2
Transdermal drug delivery system.
STRATUM SYSTEMIC
DRUG EPIDERMIS DERMIS
CORNEIUM CIRCULATION
 TDD is a painless method of delivering drugs

systemically by applying a drug formulation onto
intact and healthy skin
 Transdermal drug delivery provide a constant rate
of release of medicine to maintain concentration
level of drug for a longer period of time.
 Drug molecule having large molecular size
(>1000Dalton) cannot developed for transdermal
3
Microneedles...
• Micro needles have been formulated
as a novel drug delivery carrier for
effective transdermal delivery.
• Combines the benefits of hypodermic needle
injections and transdermal patches
• Microneedles are typically hundreds of
microns long, 1 to 50 μm wide at the tip, and
approximately 50 - 300 μm at the base.
• They can be solid/hollow and can be
fabricated as single needles or multi-needle
arrays. 4
Advantages & Disadvantages Of Microneedles
Advantages of microneedles Disadvantages of microneedles
• Large molecules can be administered • Careful use of the device may be
• Painless administration of the active needed to avoid particles ‘bouncing
off’ the skin surface
pharmaceutical ingredient
• First-pass metabolism is avoided • The thickness of the stratum corneum
• Faster healing at injection site than with a hypodermic needle, and other skin layers varies between
• No fear of needle individuals and so penetration depth
• Ease of administration of particles could vary too
• Decreased microbial penetration as compared with • The external environment, like
a hypodermic needle,the microneedle punctures hydrationof the skin, could affect
delivery
only the epidermis
• Repetitive injectionmay collapse the
• Specific skin area can be targeted for desired drug
veins
delivery enhanced drug efficacy may result in dose
• The tip of the microneedle may
reduction break off and remain within the
• Good tolerability without long-term oedema or erythema skin on removal of the patch.
• Rapid drug delivery can be achieved by
coupling the microneedles with other
technologies
5
Solid Microneedles Hollow Microneedles
6
Dissolving Microneedles Hydrogelfoming Microneedle
7
.(A) POKE & PATCH ,(B) COAT & POKE (C) POKE & RELEASE (D) POKE & FLOW
EVALUATION OF PARAMETERS
FUNCTIONAL MEASUREMENT MEASUREMENT PENETRATION

CAPACITY TEST OF INSERTION OF FRACTURE /DIFFUSION
FORCE FORCE TEST
Microscopic Measurement
inspection of of force
The force
MN tips & base Applied to a required
plate to detect needle, for
IN-VITRO IN-VIVO
cracks in base needle mechanical
plate & passage position & fracture of
skin a
continuity
resistance microneedl
during e is
insertion of
needle
evaluated.
8
Immunobiolo
gicals: Drugs:
Phlebotomy:
Biopharmac Diclofenac,
Phlebotomy -euticals: Microneedles Cosmetics lidocaine,
have an edge
is the over the
Microneedles Aspirin,
Insulin, heparin, can be
withdrawal and Albumin, other Pilocarpine etc.
of blood for methods due effectively can be
desmopressin
diagnostic to lack of used to administered
can be
purpose. delivered by pain. deliver the via
Without microneedles Eg: influenza cosmetics microneedles
vaccine, deep in to
much pain
hepatitis B skin
vaccine,flavivi
rus
vaccine etc
9
Brand name Manufactured by Applications
Vaxmat TheraJect Inc., USA Dissolvable microneedle, can

deliver 100microgram drug
Microtrans Valeritas Inc., USA Can deliver drug irrespective
of its size, structure, charge
Nanoject Debiotech, Switzerland For intradermal drug delivery
and fluid diagnotics
Janisyns Janisys, Ireland Helps delivering multiple
drugs via one patch
BD Soluvia Becton Dickinson, USA Intradermal delivery of drugs
and vaccines
Onvax Becton Dickinson, USA Delivery of vaccines
MicronJet NanoPass Inc, Israel Delivery of drugs, protiens,

vacccines
Macroflux Zosano Pharma Inc., USA Delivery of peptides and
vaccines
MicroCor Corium International Inc., USA Delivery of protiens, peptides
and vaccines
MTS 3 M Corp., USA Delivery of drugs, monoclonal
10
antibodies
BIBILIOGRAPHY
1. Bal, S. M., J. Caussin, et al. (2008). "In-vivo assessment of safety of
microneedle arrays in human skin." Eur J Pharm Sci 35(3): 193-202.
2. Banga, A. K. (1998). Electrically-Assisted Transdermal and Topical

Drug Delivery. Bristol, Taylor and Francis.
3. Lee, J. W., J.-H. Park, et al. (2008). "Dissolving microneedles for

transdermal drug delivery." Biomaterials 29(13): 2113-2124.
4. Williams, A. C. and B. W. Barry (2004). "Penetration enhancers." Adv

Drug Deliv Rev. 56(5): 603-618.
5. Gill, H. S., D. D. Denson, et al. (2008). "Effect of microneedle design

on pain in human subjects." Clin J Pain 24(7): 585-594. 11
THANKYOU
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Microneedles A Transdermal Drug Delivery System

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Microneedles In

Transdermal Drug Delivery

Under the guidance of

 TDD is a painless method of delivering drugs

FUNCTIONAL MEASUREMENT MEASUREMENT PENETRATION

Vaxmat TheraJect Inc., USA Dissolvable microneedle, can

MicronJet NanoPass Inc, Israel Delivery of drugs, protiens,

2. Banga, A. K. (1998). Electrically-Assisted Transdermal and Topical

3. Lee, J. W., J.-H. Park, et al. (2008). "Dissolving microneedles for

4. Williams, A. C. and B. W. Barry (2004). "Penetration enhancers." Adv

5. Gill, H. S., D. D. Denson, et al. (2008). "Effect of microneedle design

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