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    Fibrous Dysplasia PowerPoint Presentation

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    Fibrous dysplasia is a benign bone condition where normal bone is replaced by fibrous tissue, most commonly affecting one bone but sometimes multiple bones. It presents in children and adolescents with pain, swelling, skin pigmentation changes or neurological issues. Diagnosis is made through imaging like x-rays, CT or MRI scans showing characteristic "ground glass" bone appearance. While usually non-cancerous, rare malignant transformation can occur. Treatment focuses on symptom relief through procedures like curettage or bone reconstruction.

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    Fibrous Dysplasia PowerPoint Presentation

    Uploaded by

    Austin
    386 views29 pages
    Fibrous dysplasia is a benign bone condition where normal bone is replaced by fibrous tissue, most commonly affecting one bone but sometimes multiple bones. It presents in children and adolescents with pain, swelling, skin pigmentation changes or neurological issues. Diagnosis is made through imaging like x-rays, CT or MRI scans showing characteristic "ground glass" bone appearance. While usually non-cancerous, rare malignant transformation can occur. Treatment focuses on symptom relief through procedures like curettage or bone reconstruction.

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    Here I will look at the radiological features of fibrous dysplasia with images depicter

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    Fibrous Dysplasia PowerPoint presentation

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    Fibrous dysplasia is a benign bone condition where normal bone is replaced by fibrous tissue, most commonly affecting one bone but sometimes multiple bones. It presents in children and adolescents with pain, swelling, skin pigmentation changes or neurological issues. Diagnosis is made through imaging like x-rays, CT or MRI scans showing characteristic "ground glass" bone appearance. While usually non-cancerous, rare malignant transformation can occur. Treatment focuses on symptom relief through procedures like curettage or bone reconstruction.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    386 views29 pages

    Fibrous Dysplasia PowerPoint Presentation

    Uploaded by

    Austin
    Fibrous dysplasia is a benign bone condition where normal bone is replaced by fibrous tissue, most commonly affecting one bone but sometimes multiple bones. It presents in children and adolescents with pain, swelling, skin pigmentation changes or neurological issues. Diagnosis is made through imaging like x-rays, CT or MRI scans showing characteristic "ground glass" bone appearance. While usually non-cancerous, rare malignant transformation can occur. Treatment focuses on symptom relief through procedures like curettage or bone reconstruction.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 29

    Fibrous Dysplasia

    By; Rukundo Austin


    Definition
    Fibrous dysplasia is a benign condition in
    which normal bone is replaced by fibrous
    connective tissue due to a defect in
    osteoblast differentiation and maturation.
    The normal medullary space of the affected
    bone is replaced by fibrous tissue. It is a
    benign skeletal disorder affecting one or
    multiple bones (monostotic or polyostotic
    fibrous dysplasia (MFD and PFD
    respectively).
    Epidemiology
    Incidence not known
    Females > males
    No race predilection
    Initial symptoms manifest age 3-15
    Not heritable
    Questionable genetic transformation
    Malignant transformation in < 1%
    Variations
    • Cystic (21%)
    - Radiolucency surrounded by solid rim

    • Sclerotic (23%)
    - Dense and homogenous

    • Mixed (56%)
    - “Ground glass appearance”
    Variations, cont’d
    • Monostotic
    - Most common
    - 25% involve head and neck
    • Polyostotic
    - 15% of cases
    - 50% involve head and neck
    Con…………
    • From one-third to one-half of patients
    affected with polyostotic fibrous
    dysplasia (PFD) present yellowish or
    brownish non-elevated patches of
    cutaneous pigmentation (cafe-au-lait
    spots), situated predominantly on the
    trunk
    Images
    • Left temporal bone
    involvement
    Images
    • Right temporal bone
    lesion
    Images
    Presentation
    • Local pain, Swelling
    • Abnormal pigmentation
    • CN compression
    • Spontaneous scalp hemorrhage
    • Part of McCune-Albright’s syndrome
    Cont………………..
    Multiple endocrine disorders have been
    described in association with fibrous
    dysplasia. Of these, the best known is
    McCune-Albright syndrome, which
    consists of the triad of polyostotic
    fibrous dysplasia (typically unilateral),
    cutaneous cafe-au-lait spots (usually
    ipsilateral to the bone lesions) , and
    endocrine dysfunction(especially
    precocious puberty in girls)
    McCune-Albright’s Syndrome
    • Polyostotic fibrous dysplasia
    • Café-au-lait spots
    • Endocrinopathology:
    • Hyperthyroidism, hyperparathynoidism,
    acromegaly, diabetes mellitus, and
    Cushing syndrome
    - Precocious puberty in females
    Imaging
    • Plain radiography is first line
    • Computed tomography for complex
    regions and Magnetic resonance imaging
    Axial contrast-enhanced CT image obtained before thoracentesis
    shows a large hemothorax and lytic expansile lesions in the left 6th and
    7th ribs (arrows). The expansile 6th rib mass (*) demonstrates
    heterogeneous attenuation and compresses the left lung.
    Coronal contrast-enhanced CT image shows extensive
    expansion of the lateral 6th rib mass (*) and compression
    of the left lung.
    Plain chest radiography
    • Intraoral periapical
    radiograph showing
    diffuse mixed lesion
    and ground glass
    appearance of
    trabeculae
    • Axial computed
    tomography shows
    myxematous, diffuse
    involvement of
    multiple bones
    Histology
    • Fibroblasts within
    woven cancellous
    bone
    Differential Diagnosis
    • Eosinophilic granuloma
    • Nonossifying fibroma
    • Bone hemangioma
    • Hyperparathyroidism
    • Paget’s disease
    • Brown’s tumor
    • Aneurysmal bone cyst
    Treatment
    • No available cure
    • Curettage
    • Cranioplasty
    • Calcitonin
    NOTE
    • Genetic, non-heritable disorder
    • <1% transformation to malignancy
    • Treatment is curretage or cranioplasty
    References
    Greenberg, M. Handbook of Neurosurgery
    6th Edition. Thieme: New York 2006
    Aberration in Fibrous Dysplasia. Cancer
    Genet Cytegent 1994 Oct15;77(2) 114-7
    Radiopaedia
    http://www.jofs.in/article.asp?issn=0975-
    8844;year=2013;volume=5;issue=1;spage
    =67;epage=70;aulast=Diwan
    •THE END
    •THANK YOU FOR
    LISTENING

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