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    Protein & Peptide Drug Delivery System

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    Sandeep Saini
    This document discusses protein and peptide drug delivery systems. It begins by defining proteins and peptides, noting that proteins are composed of more than 50 amino acids joined by peptide bonds, while peptides are shorter chains of fewer than 50 amino acids. Next, it describes some key uses of proteins and peptides in pharmaceuticals to treat diseases like diabetes that result from deficiencies. The document then outlines the primary, secondary, tertiary, and quaternary structures of proteins. It concludes by examining various routes of administration for protein and peptide drugs, particularly parental routes like intravenous, intramuscular, and subcutaneous delivery.

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    Protein & Peptide Drug Delivery System

    Uploaded by

    Sandeep Saini
    286 views12 pages
    This document discusses protein and peptide drug delivery systems. It begins by defining proteins and peptides, noting that proteins are composed of more than 50 amino acids joined by peptide bonds, while peptides are shorter chains of fewer than 50 amino acids. Next, it describes some key uses of proteins and peptides in pharmaceuticals to treat diseases like diabetes that result from deficiencies. The document then outlines the primary, secondary, tertiary, and quaternary structures of proteins. It concludes by examining various routes of administration for protein and peptide drugs, particularly parental routes like intravenous, intramuscular, and subcutaneous delivery.

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    these are the Protein & Peptide Drug Delievery System for the information

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    This document discusses protein and peptide drug delivery systems. It begins by defining proteins and peptides, noting that proteins are composed of more than 50 amino acids joined by peptide bonds, while peptides are shorter chains of fewer than 50 amino acids. Next, it describes some key uses of proteins and peptides in pharmaceuticals to treat diseases like diabetes that result from deficiencies. The document then outlines the primary, secondary, tertiary, and quaternary structures of proteins. It concludes by examining various routes of administration for protein and peptide drugs, particularly parental routes like intravenous, intramuscular, and subcutaneous delivery.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    286 views12 pages

    Protein & Peptide Drug Delivery System

    Uploaded by

    Sandeep Saini
    This document discusses protein and peptide drug delivery systems. It begins by defining proteins and peptides, noting that proteins are composed of more than 50 amino acids joined by peptide bonds, while peptides are shorter chains of fewer than 50 amino acids. Next, it describes some key uses of proteins and peptides in pharmaceuticals to treat diseases like diabetes that result from deficiencies. The document then outlines the primary, secondary, tertiary, and quaternary structures of proteins. It concludes by examining various routes of administration for protein and peptide drugs, particularly parental routes like intravenous, intramuscular, and subcutaneous delivery.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 12

    PROTEIN & PEPTIDE DRUG

    DELIVERY SYSTEM

    AAKASH SONI
    M . P H A R M A I ST S E M .
    GUIDANCE BY:- DR. KEERTI JAIN
    DELHI PHARMACEUTICAL SCIENCES AND
    RESEARCH UNIVERSITY
    CONTENTS
    2

     Protein & Peptide


     Structure of protein
     Classification of Protein
     Drug Delivery System

    Protein & Peptide Drug Delivery System


    PROTEIN AND PEPTIDES
    3

     Proteins:- proteins are the large organic compounds


    made of amino acids arranged in a linear chain and
    joined together by peptide bonds.
    Proteins>50 amino acids
     Peptides:- These are short polymers formed from the
    linking, in a defines order of amino acids.
    Peptide < 50 amino acids

    Protein & Peptide Drug Delivery System


    WHY PROTEIN AND PEPTIDE ARE USED
    4

     The protein and peptides are very important in biological


    cells.
     Lack of proteins and peptides causes disease like diabetes
    mellitus.
     Diabetes mellitus is caused due to the lack of protein
    called INSULIN.
     Now a days R-DNA technology and hybridoma
    techniques also used in protein and peptide based
    pharmaceutical.
    Protein & Peptide Drug Delivery System
    ADVANTAGE
    5

     Erythropoietin used for production of RBC


     Tissue plasminogen activator is used for Heart attack,
    stroke.
     Oxytocin maintain labor pain.
     Bradykinin increases the periphaeral circulation.
     Somatostatin decrease bleeding in gastric ulcer.
     Gonadotropin induce ovulation.
     Insulin maintain blood sugar level.

    Protein & Peptide Drug Delivery System


    FUNCTIONS
    6

     https://www.slideshare.net/BrajeshKumar67/protein-
    and-peptide-drug?from_m_app=android
     Transport and storage of small molecules.
     Cordinated motion via muscle contraction.
     Mechanical support from fibrous protein.
     Generation and transmission of Nerve Impulses.
     Enzymatic catalysis
     Immune protection through antibodies.
     Control of Growth and Differentiation via Hormones.
    Protein & Peptide Drug Delivery System
    STRUCTURE OF PROTEIN
    7

     The structure of protein divided into four types:-


     Primary Structure:- The Amino Acid sequence
     Secondary Structure:- Regularly repeating local
    structures stabilized by hydrogen bond.
     Tertiary Structure:-Three Dimensional structure of
    polypeptide.
     Quaternary Structure:- The Structure formed by several
    protein molecules.

    Protein & Peptide Drug Delivery System


    CLASSIFICATION OF PROTEIN
    8

    Depending on the number of amino acids they are :-


     Polypeptide Protein
     Oligo peptides proteins
     Fibrous proteins
     Globular proteins
     Oligo meric protein

    Protein & Peptide Drug Delivery System


    DELIVERY OF PROTEINS
    9

    Drug delievery

    Route of Drug
    Administration Modification

    Pulmonary Miscellaneous Parental Oral PEGylation Pro-Drug Polymer Depot


    Transdemal

    Implants Ocular Nasal

    Protein & Peptide Drug Delivery System


    PARENTRAL ROUTES OF ADMINISTRATION
    10

     Parentral route is most efficient way for systemic


    delivery of proteins and peptides.
     This is the best choice to achieve therapeutic activity.
    Mainly 3 routes of administration:-
     Intravascular
     Intramuscular
     Subcutaneous
    Protein & Peptide Drug Delivery System
    ADVANTAGE & DISADVANTAGE
    11

    Advantage:- Disadvantage:-
     Route of Delivery for 95% of •Problems with overdosing,
    proteins necrosis
     Allows rapid and complete •Local tissue
    absorption reaction/hypersensitivity
     Avoids first pass metabolism •Everyone hates getting a needle

    Protein & Peptide Drug Delivery System


    THANKYOU

    Protein & Peptide Drug Delivery System

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