1-1 Asystole
1-1 Asystole
1-1 Asystole
Asystole
Definition: Asystole
• Asystole is defined as the complete absence of electrical
activity in the myocardium (heart muscle).
• Usually this represents extensive myocardial ischemia
(insufficient blood supply) or infarct (damaged tissue), with a
very grim prognosis.
• Most often, asystole represents a confirmation of death as
opposed to a dysrhythmia requiring treatment.
Additional Information
• Unless Appendix C (cessation of resuscitation) applies, the
team leader must consider the differential diagnosis while
beginning and maintaining CPR and interventions.
• Asystole should not be defibrillated, as the increased vagal
tone may prevent resuscitation. If able to do so, rescuers
should confirm asystole when faced with a “flat line” on the
monitor.
• One should always consider these possible causes of asystole
and manage accordingly: drug overdose, hypokalemia,
hypoxemia, hypothermia, and pre-existing acidosis.
Additional Information
• Asystole can be primary or secondary.
• Primary asystole occurs when the heart's electrical system
intrinsically fails to generate a ventricular depolarization.
• This may result from ischemia or from degeneration (i.e.,
sclerosis) of the sinoatrial (SA) node or atrioventricular (AV)
conducting system.
• Primary asystole usually is preceded by a bradydysrhythmia
due to sinus node block-arrest, complete heart block, or both.
Causes
• Reflex bradyasystole/asystole can result from:
• ocular surgery
• retrobulbar block
• eye trauma
• direct pressure on the globe,
• maxillofacial surgery,
• hypersensitive carotid sinus syndrome, or
• glossopharyngeal neuralgia.
• Episodes of asystole and bradycardia have been documented as
manifestations of left temporal lobe complex partial seizures.
Causes
• Secondary asystole occurs when factors outside of the heart's
electrical conduction system result in a failure to generate any
electrical depolarization.
• In this case, the final common pathway is usually severe tissue
hypoxia with metabolic acidosis.
• Asystole or bradyasystole follows untreated VF and commonly
occurs after unsuccessful attempts at defibrillation.
• This forebodes a dismal outcome.
Morbidity and Mortality
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