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Paper-Based Disposable Analytical Devices For On-Site Applications

The document discusses paper-based analytical devices (μPADs) for on-site applications. Some key advantages of μPADs are that they are inexpensive, sensitive, specific, user-friendly, rapid, equipment-free, and deliverable to end users. Common fabrication methods for μPADs include wax printing, inkjet printing, photolithography, flexography, laser treatment, plotting, and stamping. μPADs have applications in biochemical detection, immunological detection, molecular detection, environmental detection, and other detection methods.

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Shuaib Mubarak
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62 views14 pages

Paper-Based Disposable Analytical Devices For On-Site Applications

The document discusses paper-based analytical devices (μPADs) for on-site applications. Some key advantages of μPADs are that they are inexpensive, sensitive, specific, user-friendly, rapid, equipment-free, and deliverable to end users. Common fabrication methods for μPADs include wax printing, inkjet printing, photolithography, flexography, laser treatment, plotting, and stamping. μPADs have applications in biochemical detection, immunological detection, molecular detection, environmental detection, and other detection methods.

Uploaded by

Shuaib Mubarak
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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kfupm.edu.

sa

Paper-based disposable analytical devices for on-


site applications

Name: Shuaib Ahmed Mubarak

ID : 201708650
why paper based analytical devices.

μPAD
In expensive
Sensitive Paper
Specific Capillary action
Biocompatible
User-friendly
Thin and flexible
Rapid and robust Easy and cheap
Equibment free manufacture
Delivarable to Hyrophilicity
end user High surface area
Biologically Easy to fabricate
compatible
Fabrication methods
Wax printing
Inkjet printing
Photolithography
Feloxothogrpahy
Laser treatment
Plotting
Stamping
Wax printing

Advantages

 Simple method
 Rapid process
 Adequate for most μPADs
 Hydrophilic wax channels not
exposed to polymers or solvents

Disadvantages
 Expensive wax
 Extra heating step after deposition
 Design of patterns must account
for wax spreading
Ink jet printing

Advantages
 Produce large scale fast and simple
 Uses cheap patterning agents
 Reagents easily inkjet printed

Disadvantages
 Requires custom inject printer
 Can be slow
 hydrophilic areas exposed to polymers
Photolithography

Advantages

 high resolution of microfluidic


Channels
 sharp barriers
 Rapid method

Disadvantages

 Requires expensive equipment;


 complex steps
 expensive reagents
 Vulnerable to bending
Fabrication methods of 3D μPAD
Applications

(Gabriel et al. 2017)


Color scale for visual detection of tear glucose levels.

(Gabriel et al. 2017)


(Lopez-Ruiz et al. 2014)
Microfluidic device with the
reagents placed in each
sensing area

(Lopez-Ruiz et al. 2014)


Conclusion
Based on the literature review paper based
analytical devises is used in :

 Biochemical detection
 Immunological detection
 Molecular detection
 Environmental detection
 Other detection methods
References
[1] D. D. Liana, B. Raguse, J. Justin Gooding, and E. Chow, “Recent
advances in paper-based sensors,” Sensors (Switzerland), vol. 12, no. 9,
pp. 11505–11526, 2012.
[2] Y. He, Y. Wu, J. Z. Fu, and W. Bin Wu, “Fabrication of paper-
based microfluidic analysis devices: a review,” RSC Adv., vol. 5, no. 95,
pp. 78109–78127, 2015.
[3] Y. Yang, E. Noviana, M. P. Nguyen, B. J. Geiss, D. S. Dandy, and
C. S. Henry, “Paper-Based Microfluidic Devices: Emerging Themes and
Applications,” Anal. Chem., vol. 89, no. 1, pp. 71–91, 2017.
[4] D. M. Cate, J. A. Adkins, J. Mettakoonpitak, and C. S. Henry,
“Recent Developments in Paper-Based Microfluidic Devices,” Anal.
Chem., vol. 87, no. 1, pp. 19–41, 2015.
[5] Y. Xia, J. Si, and Z. Li, “Fabrication techniques for microfluidic
paper-based analytical devices and their applications for biological
testing: A review,” Biosens. Bioelectron., vol. 77, pp. 774–789, 2016.

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