Scribd
Upload
128 views15 pages

Cell 2

The cell was first observed by Robert Hooke in 1665 and named by him. Anton van Leeuwenhoek first observed a live cell under a microscope. In 1838, Theodor Schwann and Matthias Schleiden developed the cell theory which states that all living things are made of one or more cells, cells come only from pre-existing cells, and the cell is the basic unit of structure and function. Rudolph Virchow further contributed to cell theory by stating that all cells come from pre-existing cells. The development of techniques like electron microscopy, cell culture, and fluorescence furthered the understanding of cells.

Uploaded by

tea
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
128 views15 pages

Cell 2

The cell was first observed by Robert Hooke in 1665 and named by him. Anton van Leeuwenhoek first observed a live cell under a microscope. In 1838, Theodor Schwann and Matthias Schleiden developed the cell theory which states that all living things are made of one or more cells, cells come only from pre-existing cells, and the cell is the basic unit of structure and function. Rudolph Virchow further contributed to cell theory by stating that all cells come from pre-existing cells. The development of techniques like electron microscopy, cell culture, and fluorescence furthered the understanding of cells.

Uploaded by

tea
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
You are on page 1/ 15

CELL

THE BASIC UNIT OF LIFE


CELL
• The cell was first discovered and named by Robert Hooke in 1665.he
said that it looked similar to cellula or small rooms which monks in
habited, thus deriving the name.
• He actually saw was the dead cell walls of plant cell appeared under
a microscope
• Anton van Leeuwenhook was the first man to witness a live cell
under a microscope.
Robert Hooke Cellular structure
Anton van Leeuwenhoek Animalcules
CELL THEORY DEVELOPMENT
• 1838,Theodor Schwann and Matthias Schleiden were enjoying
after-dinner coffee and talking about their studies on cells.
• Schleiden describe plant cells with nuclei, he was struck by the
similarity of these plant cells to cells he had observed in animal
tissues.
• Schwann published his book on animal and plant cells (SCHWANN
1838)
Theodor Schwann cell theory

Matthias Schleiden cell theory


3 conclusions about cells
1. The cell is the unit of structure, physiology and organization in living things.
2. The cell retains a dual existence as a distinct entity and a building block in the
construction of organisms.
3. Cell forms by free-cell formation.
• The third statement was denounced later when Rudolph Virchow’s experiment
made a powerful statement, “OMNIS CELLULA E CELLULA” All cells only arise
from pre-existing cells”
The salient features of cell theory are:
1. All organisms are composed of one or more cells.
2. All cells arise from pre-existing cells.
3. Cell is the basic structural as well as functional unit for all organisms.
Rudolph Virchow cell theory
CELL THEORY DEVELOPMENT
• By the time the study of molecular biology became popular in the
mid-20th century, cell biology research exploded in the 1950s. It
became possible to maintain, grow and manipulate cells outside of
living organisms.
• The first continuous cultured cell line in 1951 by George Otto Gey
and his co-workers was derived from the cervical cancers of
Henrietta Lacks,who died of cancer in the same year.
• The cell line, also known as the HeLa cells, have been watershed in
studying cell biology, in the way that the structure of DNA was
considered to be the most important breakthroughs of molecular
biology.
CELL THEORY DEVELOPMENT
• In an avalanche of progress in the study of cells,the coming decade
included that characterization of the minimal media requirements
for cells and development of sterile cell culture techniques.
• It was also aided by the prior advances in electron microscopy, and
later advances, like the development of transfection methods,
discovery of small interfering RNA(siRNA), and the discovery of
green fluorescent protein in jellyfish.
Electron microscopy Green Fluorescent protein

Transfection method Small interfering RNA


Timeline on the history of the cell
• 1665- Robert Hooke describe cells in his book MICROGRAPHIA
• 1674- Leeuwenhoek discovered protozoa.
• 1833- Brown described the cell nucleus in cells of the orchid
• 1838- Schleiden and Schwann proposed cell theory.
• 1840- Albrecht von Roelliker realized that sperm and egg cells are also cells.
• 1856- N.Pringsheim observed how a sperm cell penetrated an egg cell
• 1857- Kolliker described mitochondria
• 1858- Rudolf Virchow expounded on his famous conclusion: omniscellula e cellula,tha is cells develop only from existing
cells.
• 1879- Flemming described chromosome behavior during mitosis.
• 1883- germs cells are haploid,chromosome theory of heredity
• 1898- Golgi described golgi apparatus
• 1926- Svedberg developed the first analytical ultracentrifuge
• 1938- Behrens used differential centrifugation to separate nuclei from cytoplasm
• 1939- Siemens produced the first commercial transmission electron microscope
• 1941- Coons used fluorescent labeled antibodies to detect cellular antigens
• 1952- Gey and co-workers established a continuous human cell line
• 1953- Crick, Wilkins and Watson proposed structure of DNA double helix
• 1955- Eagle systematically defined the nutritional needs of animal cells in culture.
Timeline on the history of the cell
• 1957- Meselson, Stahl and Vinograd developed density gradient centrifugation in cesium
chloride solutions for separating nucleic acids.
• 1965- Ham introduced a defined serum-free medium. Cambridge Instruments produced the first
commercial scanning electron microscope
• 1976- Sato and colleagues published papers showing that different cell lines require different
mixtures of hormones and growth factors in serum-free media
• 1981- creation of first knockout mouse
• 1998- Mice are cloned from somatic cells
• 2000- Human genome DNA sequence draft.
CELL THEORY DEVELOPMENT
• Prior to 1931 when the first electron microscope was developed.
• The electron microscope not only showed more details of previously
known parts of the cell but also revealed new parts.
• Cells and cell structures can now be examined at magnifications of up to
500000 times and more.

You might also like