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    Urea Cycle

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    Pious
    The urea cycle is a metabolic pathway that involves five enzymes to convert ammonia into urea in the liver. Urea is then excreted in urine, which is less toxic than ammonia. There are different nitrogen waste excretion strategies among animals, including ureotelism in terrestrial vertebrates via the urea cycle, ammonotelism in fish, and uricotelism in birds and reptiles. Disorders of the urea cycle can occur if any of the five enzymes involved in the pathway are defective. The urea cycle is also interconnected with the TCA cycle through various intermediates.

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    Urea Cycle

    Uploaded by

    Pious
    72 views8 pages
    The urea cycle is a metabolic pathway that involves five enzymes to convert ammonia into urea in the liver. Urea is then excreted in urine, which is less toxic than ammonia. There are different nitrogen waste excretion strategies among animals, including ureotelism in terrestrial vertebrates via the urea cycle, ammonotelism in fish, and uricotelism in birds and reptiles. Disorders of the urea cycle can occur if any of the five enzymes involved in the pathway are defective. The urea cycle is also interconnected with the TCA cycle through various intermediates.

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    Urea cycle, Biochemistry

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    The urea cycle is a metabolic pathway that involves five enzymes to convert ammonia into urea in the liver. Urea is then excreted in urine, which is less toxic than ammonia. There are different nitrogen waste excretion strategies among animals, including ureotelism in terrestrial vertebrates via the urea cycle, ammonotelism in fish, and uricotelism in birds and reptiles. Disorders of the urea cycle can occur if any of the five enzymes involved in the pathway are defective. The urea cycle is also interconnected with the TCA cycle through various intermediates.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    72 views8 pages

    Urea Cycle

    Uploaded by

    Pious
    The urea cycle is a metabolic pathway that involves five enzymes to convert ammonia into urea in the liver. Urea is then excreted in urine, which is less toxic than ammonia. There are different nitrogen waste excretion strategies among animals, including ureotelism in terrestrial vertebrates via the urea cycle, ammonotelism in fish, and uricotelism in birds and reptiles. Disorders of the urea cycle can occur if any of the five enzymes involved in the pathway are defective. The urea cycle is also interconnected with the TCA cycle through various intermediates.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 8

    Urea Cycle

    1
    Disposal of Ammonia

    NH3

    Ureotelic animals: Ammonotelic


    Most terrestrial animals: Fishes and Uricotelic animals:
    vertebrates also other aquatic birds, reptiles
    sharks vertebrates

    2
    Metabolism of Protein (Amino Acid)

    Waste or reuse
    (Urea Cycle)

    3
    Why Urea? Why Ammonia?
    Non toxic  highly toxic
    Water soluble  Main reason to form urea is
    Combines two waste to reduce levels of ammonia
    products into (CO2, NH3) “Ammonia” often refers to
    one molecule (NH3+ NH4+)

    Conversion of Glutamate into α-Ketoglutarate

    4
    Introduction to Urea Cycle

    Urea cycle is the first metabolic cycle to be elucidated.


    The cycle is known as Krebs-Henseleit cycle.
    Ornithine is the first member of the reaction, it is also
    called as Ornithine cycle.
    Urea is synthesized in the liver.
    Then secreted into blood stream.
    And taken up by the kidneys for excretion in the urine.
    Urea synthesis is a five step cyclic process, with five
    distinct enzymes.
    The first two enzymes are present in mitochondria while
    the rest are localized in cytosol.
    5
    কার

    ছেলে
    ও
    ASP

    A
    আগ্রহ-ছেে
    F
    ও কার ছেলে ছে ASP
    আগ্রহ-ছেে F A
    কযাডার

    C-OAAA…….

    6
    Metabolic Disorders of Urea Cycle

    Disorders Defective Enzymes


    Hyperammonemia-I Carbamoyl Phosphate Synthase-I
    Hyperammonemia-II Ornithine Transcarbamoylase

    Citrullinemia Arginosuccinate Synthase

    Arginosuccinic aciduria Arginase

    Argininemia Arginase

    7
    Interrelation between Urea and TCA Cycle

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