Anti Emetics
Anti Emetics
Anti Emetics
Presented by:
Puja Bohora
Sudisha Maharjan
Purnima K.C
Anisha Maharjan
Rupa Rana
Ram Babu Thapa
Sunita Nakarmi
(B.Pharmacy, 3rd yr.)
Emesis
• Emesis is the forceful expulsion of the contents of the stomach and upper
intestinal tract through the mouth.
Cannabinoids
Examples: dronabinol
• It is principal psychoactive component of marijuana.
• Used to prevent chemotherapy induced vomiting not responding to other
antiemetics.
• Because of it’s serious side effects like sedation, hallucination,
disorientation, tachycardia, palpitation, increased appetite and drug
dependence, kept as reserve antiemetic.
Adjuvant anti-emetics
Glucocorticoids
• Examples : dexamethasone, betamethasone, methylprednisolone
• They are commonly used corticoids in combination with ondansetron
or metoclopramide in the treatment of anti-cancer drug induced
vomiting.
• They increase antiemetic activity.
Benzodiazepines
• Examples : lorazepam, alprazolam
• Used to control psychogenic and anticipatory vomiting.
• Their beneficial effect is mainly due to their sedative , amnesic and
antianxiety effects.