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Curing Aging: Burz Ana, Cherecheș Milena, Condrat Alice, Lăpușan Bianca, Suciu Titus Clsax-Aa

The document discusses various approaches to curing aging that scientists are exploring, including mitochondrial DNA engineering to reduce reactive oxygen species, eliminating senescent cells that accumulate with age, increasing levels of NAD+ to support DNA repair and cell health, and utilizing stem cells to reinvigorate aging cells. It argues that aging will likely require multiple therapies targeting different mechanisms rather than a single cure and encourages supporting this research through the lifesnap.io organization.

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Titus Suciu
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103 views7 pages

Curing Aging: Burz Ana, Cherecheș Milena, Condrat Alice, Lăpușan Bianca, Suciu Titus Clsax-Aa

The document discusses various approaches to curing aging that scientists are exploring, including mitochondrial DNA engineering to reduce reactive oxygen species, eliminating senescent cells that accumulate with age, increasing levels of NAD+ to support DNA repair and cell health, and utilizing stem cells to reinvigorate aging cells. It argues that aging will likely require multiple therapies targeting different mechanisms rather than a single cure and encourages supporting this research through the lifesnap.io organization.

Uploaded by

Titus Suciu
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPTX, PDF, TXT or read online on Scribd
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CURING AGING

Burz Ana, Cherecheș Milena, Condrat Alice, Lăpușan Bianca, Suciu Titus
Cls a X-a A
Our focus

✤ Health is one of the most important elements of life

✤ The human race has reached the maximum lifespan in history

✤ Unexpected turn: we spend a large amount of time in pain due to


ageing

✤ lifesnap.io is an association of scientists that is interested in optimising


healthspan
Mitochondrial DNA engineering
✤ Mitochondria: cellular organelle that is
responsible of producing energy used by the cell
to perform all their functions ✤ the main dysfunctions
associated with
✤ In this process, the organelle accidentally
produces toxic molecules called reactive oxygen mitochondrial mutations
species that interact with DNA causing changes are Parkinson and
in gene composition
muscular diseases
✤ The final result is an abnormal cell that affects ✤ Scientists are looking for
the whole system
methods of creating gene
backups located in the
nucleus(where they are
much safer)
Senescent cells
✤ Cells undergo mitosis, process which
affects chromosomal ends called telomers
✤ Concomitant with telomere deterioration,
apoptosis occurs (programmed cell death)
✤ Senescent cells do not follow the normal
pathway, transforming themselves into
abnormal ones
✤ A great number of senescent cells is associated with
age and a number of health issues, such as diabetes
and kidney failure

✤ A way of combating this problem is by injecting a


protein that is not present in “zombie”cells, thus not
affecting normal ones
NAD+
✤ NAD+ is a coenzyme responsible of general cell well being , as well as DNA reparation

✤ With age, NAD+ intracellular concentration decreases, as we have half of it at the age of
50 in comparison with 20

✤ This coenzyme deficiency causes skin cancer, Alzheimer’s, cardiovascular and multiple
sclerosis

✤ Its conformation enables it to pass the membrane, so it cannot be ingested as a pill

✤ Scientist discovered a chemical compound able to enter the cell, and transform itself into
NAD+

✤ NASA developed interest in this research, as it benefits astronauts with its ability to
repair DNA damaged by cosmic radiation

✤ In conclusion, NAD+ represents a strong candidate, as it may be the first anti-aging pill
Stem cells
✤ Stem cells are totipotent,
meaning that they ensure a flow
of young cells with the ability to
differentiate into any type
✤ Their number declines with age,
causing a number of dysfunctions

✤ Scientists have taken stem cells from embryos


and injected them in adult mice brains (in the
hypothalamus=regulates a number of bodily
functions)

✤ they discovered that the cells reinvigorated


neurons by secreting micro RNAs, a chemical
compound that regulates metabolism
Conclusion

✤ In conclusion there isn’t only one miracle cure of


aging

✤ We need a number of different therapies in order


to fix this

✤ Major methods: mitochondrial DNA engineering,


killing senescent cells, DNA reparation with
NAD+ and regulating metabolism with stem cells

✤ If you want to become part of a community that


actively supports such an important research, you
can fund these ideas on lifespan.io

✤ Grow old and healthy with us!

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