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    Embryology Muscularskeletal System

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    Lale Yuni Wulandari
    The muscular system develops primarily from the mesodermal germ layer. Skeletal muscle develops from paraxial mesoderm which forms somites and somitomeres. Myotome cells within the somites split off and migrate to form muscle fibers through fusion of myoblasts. Somites form the body wall musculature while somitomeres form muscles of the head, face, neck and organs. Limb musculature develops from mesenchyme near limb buds derived from somites. Cardiac and smooth muscle develop from splanchnic mesoderm surrounding the heart and gut, respectively.

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    Embryology Muscularskeletal System

    Uploaded by

    Lale Yuni Wulandari
    19 views28 pages
    The muscular system develops primarily from the mesodermal germ layer. Skeletal muscle develops from paraxial mesoderm which forms somites and somitomeres. Myotome cells within the somites split off and migrate to form muscle fibers through fusion of myoblasts. Somites form the body wall musculature while somitomeres form muscles of the head, face, neck and organs. Limb musculature develops from mesenchyme near limb buds derived from somites. Cardiac and smooth muscle develop from splanchnic mesoderm surrounding the heart and gut, respectively.

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    Embriologi

    Original Title

    428852_Embryology Muscularskeletal System

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    The muscular system develops primarily from the mesodermal germ layer. Skeletal muscle develops from paraxial mesoderm which forms somites and somitomeres. Myotome cells within the somites split off and migrate to form muscle fibers through fusion of myoblasts. Somites form the body wall musculature while somitomeres form muscles of the head, face, neck and organs. Limb musculature develops from mesenchyme near limb buds derived from somites. Cardiac and smooth muscle develop from splanchnic mesoderm surrounding the heart and gut, respectively.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    19 views28 pages

    Embryology Muscularskeletal System

    Uploaded by

    Lale Yuni Wulandari
    The muscular system develops primarily from the mesodermal germ layer. Skeletal muscle develops from paraxial mesoderm which forms somites and somitomeres. Myotome cells within the somites split off and migrate to form muscle fibers through fusion of myoblasts. Somites form the body wall musculature while somitomeres form muscles of the head, face, neck and organs. Limb musculature develops from mesenchyme near limb buds derived from somites. Cardiac and smooth muscle develop from splanchnic mesoderm surrounding the heart and gut, respectively.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 28

    Development of

    Musculoskletal system
    Muscular System
    • As with the skeltal system most
    of the
    • muscular system also develops
    from the
    • mesodermal germ layer
    • Smooth muscle develops from
    splanchnic
    • mesoderm which surrounds gut
    /derivatives.
    • • Cardiac muscle develops from
    splanchnic
    • mesoderm which surrounds the
    heart tube.
    TRUNK MUSCULATURE
    • Skeletal muscle of the trunk develops
    from paraxial mesoderm (which forms
    somites & somitomeres)
    FATE OF MYOTOME CELLS
    • Myotome cells split
    • off, move to their
    • definitive locations, &
    • become elongated &
    • spindle shaped
    • (called myoblasts)
    • Many myoblasts fuse
    • to become
    • Multinucleated muscle fibres.
    • Myofibrils appear
    in cytoplasm.
    • By 12/52 cross
    striations typical
    for skeletal muscle
    appear.
    • Somites: form body wall musculature. It
    forms a dorsal epimere & a ventral
    hypomere.
    • The epimere forms the vertebral
    extensors; while the hypomere forms the
    muscles of the body wall and limbs.
    • Note the different innervation dorsal
    and ventral primary rami
    Somitomeres
    • same process in head and neck region
    i.e. form myoblasts which will form extra
    ocular eye muscles, face, larynx, tongue
    etc
    Head Musculature
    Limb Musculature
    • Condensation of mesenchyme near the
    base of limb buds (7th week)
    • Mesenchyme is derived from
    dorsolateral cells of somites
    • Migrate into limb bud to form the
    muscles
    • Connective tissue dictates the pattern of
    muscle formation
    • Upper limb buds lie opposite the lower
    five cervical and upper two thoracic
    Limb Musculature
    • Lower limb buds lie
    opposite lower
    lumbar and upper
    two sacral segments
    • There is a 180°
    medial rotation of
    the lower limb
    compared to
    developing upper
    limb (angle of flexion
    differs)
    Cardiac Muscle
    • Develops from splanchnic mesoderm
    surrounding the endothelial heart tube
    • Myoblasts adhere to one another by
    intercalated discs
    • Myofibrils develop as in skeletal muscle
    but do not fuse
    • Few special bundles become visible
    (Purkinje fibers)
    Smooth Muscle
    Clinical Correlations
    Skletal system
    • The skeletal system develops from the
    mesodermal germ layer
    • Mesenchymal cells are pluripotent,
    meaning they have the ability To
    differentiate down several different
    pathways. One cell can become many
    different cell-types
    • The embryonic mesoderm can be
    divided into three basic regions,
    proceeding from medial to lateral :
    – Paraxial mesoderm
    – Intermediate mesoderm
    – Lateral plate mesoderm

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