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    BACTERIOPHAGE

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    Robin Oben
    Bacteriophages, or phages, are viruses that infect and replicate within bacteria. They were first observed in the late 19th century as entities that could pass through filters and reduce bacterial growth. Phages have a protein coat called a capsid that protects their genetic material and may have an additional envelope. They insert their DNA into the host bacteria and can either lyse the cell through a lytic cycle or integrate into the genome through a lysogenic cycle. Knowledge of phage structure and infection process allows their therapeutic use against bacterial diseases as phages only target bacteria.

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    BACTERIOPHAGE

    Uploaded by

    Robin Oben
    274 views21 pages
    Bacteriophages, or phages, are viruses that infect and replicate within bacteria. They were first observed in the late 19th century as entities that could pass through filters and reduce bacterial growth. Phages have a protein coat called a capsid that protects their genetic material and may have an additional envelope. They insert their DNA into the host bacteria and can either lyse the cell through a lytic cycle or integrate into the genome through a lysogenic cycle. Knowledge of phage structure and infection process allows their therapeutic use against bacterial diseases as phages only target bacteria.

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    Bacteriophages, or phages, are viruses that infect and replicate within bacteria. They were first observed in the late 19th century as entities that could pass through filters and reduce bacterial growth. Phages have a protein coat called a capsid that protects their genetic material and may have an additional envelope. They insert their DNA into the host bacteria and can either lyse the cell through a lytic cycle or integrate into the genome through a lysogenic cycle. Knowledge of phage structure and infection process allows their therapeutic use against bacterial diseases as phages only target bacteria.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    274 views21 pages

    BACTERIOPHAGE

    Uploaded by

    Robin Oben
    Bacteriophages, or phages, are viruses that infect and replicate within bacteria. They were first observed in the late 19th century as entities that could pass through filters and reduce bacterial growth. Phages have a protein coat called a capsid that protects their genetic material and may have an additional envelope. They insert their DNA into the host bacteria and can either lyse the cell through a lytic cycle or integrate into the genome through a lysogenic cycle. Knowledge of phage structure and infection process allows their therapeutic use against bacterial diseases as phages only target bacteria.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 21

    Camillo, Rosselle C.

    BSEd-3A
    Also known simply as phage; a virus that
    attacks and infects bacteria.
    The term derived from the Greek word phagein
    which means to eat bacteria.
    Found in any bacterial colonies. Mostly in soil
    and sea water.
    Resistance to antibiotics
    Carries only genetics information needed for
    replication of their nucleic acid and synthesis of
    their protein coats.
    Hankin (1896) reported that the waters of the
    Ganges and Jumna rivers in India had marked
    antibacterial action (against Vibrio cholerae, restrict
    epidemic) which could pass through a very fine
    porcelain filter; this activity was destroyed by
    boiling.
    Edward Twort (1915) and Felix d'Herelle (1917)
    independently reported isolating filterable entities
    capable of destroying bacterial cultures and of
    producing small cleared areas on bacterial lawns.
    It was F d'Herelle, a Canadian working at the Pasteur
    Institute in Paris, who gave them the name
    "bacteriophages"-- using the suffix phage (1922).
    Knowledge of the phage structure,
    understanding the mechanism of
    phage-cell surface interaction, and
    revealing the process of switching the
    cell replication machinery for phage
    propagation would allow the design of
    phages specific for bacterial illnesses.
    The Major parts of Bacteriophage

    Capsid protein coat that makes


    up most the virus and gives it a
    shape.
    Nucleic Acid genetic information
    in the form of DNA or RNA.
    Envelope an additional protective
    coating usually made up of lipids,
    proteins and carbs.
    The lytic cycle: The phage infects a
    bacterium, hijacks the bacterium to
    make lots of phages, and then kills the
    cell by making it explode (lyse).
    The lysogenic cycle: The phage infects
    a bacterium and inserts its DNA into the
    bacterial chromosome, allowing the
    phage DNA (now called a prophage) to
    be copied and passed on along with
    the cell's own DNA.
    Phage therapy is the use of
    bacteriophage viruses to combat
    bacteria instead of using antibiotics.
    Bacteriophage only attacks bacteria
    nothing else which make it useful in
    medicine as it does not affect the
    patient only the bacteria,
    Phage bacteria are the therapeutic use
    of bacteriophage to threat pathogenic
    bacterial infections.
    Nucleic acid properties.
    Phage morphology.
    Isa procedure for characterizing
    and detecting bacteria strain by
    their reaction whether they are
    susceptible or resistance to
    various known strain of phage.

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