Peptic Ulcer Disease
Peptic Ulcer Disease
Peptic Ulcer Disease
BSN II Group A
Peptic Ulcer is circumscribed erosion in or
loss of, the mucous membrane lining in the
gastrointestinal tract. It may occur in the
esophagus (esophageal ulcer), stomach
(gastric ulcer), duodenum (duodenal ulcer) or
jejunum (jejunal ulcer). The stomach and
duodenum is the most common sites.
Peptic Ulcer may result from excess acid
production or from a breakdown in the
normal mechanisms protecting the mucous
membranes. It is also associated with stress
and intake of certain drug (eg.
Corticosteroids and certain NSAIDs).
Helicobacter pylori, a spiral shaped bacterium
found in the stomach is generally
acknowledged as the main cause for most
peptic ulcers and many cases of chronic
gastritis.
Duodenal Ulcer Gastric Ulcer
Age: 25-50 Usually 50 and over
Male:Female= 2-3:1 Male:Female = 1:1
88% of peptic ulcer are duodenal 15% of peptic ulcer are gastric
Signs and Symptoms, Clinical Findings
-Hypersecretion of stomach acid -Normal-hyposecretion of
(HCL) stomach acid (HCL)
-May have wt gain -wt loss may occur
-Pain occurs 2-3 hrs after a meal; -pain occur ½ to 1 hr after a meal;
often awakened 1-2am; ingestion rarely occurs at night; may be
of food relieves pain relieved by vomiting; ingestion of
-vomiting uncommon food does not help, sometimes
-hemorrhage less likely than with increases pain
gastric ulcer, but if present, -vomiting common
melena more than hematemesis -Hemorrhage more likely to occur
-more likely to perforate than than with duodenal ulcer;
gastric ulcers hematemesis more common than
-Common on type O melena.
Duodenal Ulcer Gastric Ulcer
•H. Pylori •H. Pylori
•Alcohol •Gastritis
•Smoking •Alcohol
•Cirrhosis •Smoking
•Stress •Use of NSAID’s
•Stress
Over the past few decades,the incidence of
peptic ulcer disease and ulcer complication
has decreased.
There has however,been an increase in ulcer
disease.
Gain the necessary information about the
Bile
intestine
Two types of contraction occur regularly in
small intestine
Segmentation contraction
Intestinal peristalsis
Absorption is the primary function of the
small intestine. Process of absorption begins
in the jejunum and is accomplished by both
active transport and diffusion across the
intestinal wall into the circulation.
Nutrients are absorbed at specific locations
throughout the small intestine and
duodenum, whereas fats, proteins,
carbohydrates, sodium, chloride are absorbed
in the jejunum. Vitamin B12 and bile salts are
absorbed in the ileum. Magnesium,
phosphate and potassium are absorbed
throughout the small intestine.
Contributory Factors
Precipitating Factors
-skipping meals
-Lifestyle
-Diet: Coffee
-Work
-Stress and over work
-Diet
-use of NSAID’s
(mefenamic acid)
Abdominal pain
Irritation of the lining
(mucosa) of the stomach, Mesenteric
duodenum, proximal of insufficiency
small intestine.
Mucosal Erosion
↓ O2 carrying
capacity
Anemia
↓ Cardiac Output
Bp: 100/60
PR: 78
Compensatory
↓ bld flow to GI
mechanism
Decrease
Shifting of bld to peristalsis
vital organs (ex.
Heart)
Bowel
obstruction
constipation
Name of Drug: Furosemide 20mg
IV after each unit
Time Given:
March 13, March 14
Classification: Loop Diuretic
Adverse Effect:
CNS: dizziness, vertigo, paresthisias, xanthopsia, weakness, headache,
drowsiness, fatigue, blurred vision, tinnitus, irreversible hearing loss
CV: orthostatic hypotension, volume depletion, cardiac arrhythmias
Dermatologic: rash, photosensitivity, pruritus, urticaria, pupura, exofoliative
dermatitis, erythema multiforme
GI: nausea, vomiting, anorexia, oral and gastric irritation, constipation,
diarrhea, acute pancreatitis, jaundice
GU: polyuria, nocturia, glycosuria, urinary bladder spasm
Hematologic: leukopenia, anemia, thrombocytopenia, fluid and electrolyte
imbalance, hyperglycemia, hyperuricemia
Other: muscle cramps and muscle spasm
Indication:
-treatment of edema associated with CHF, hepatic cirrhosis, renal disease
and hypertension
Contraindication:
-contraindicated with allergy to furosemide, sulfonamides
-allergy to tartrazine
-anuria, severe renal failure, hepatic coma
-pregnancy and lactation
-use cautiously with SLE, gout and DM
Nursing Consideration:
-profound diuresis with water and electrolyte depletion can occur; careful
medical supervision is required
-administer with food or milk to prevent GI upset
-reduce dosage if given with other antihypertensive; readjust dosage gradually
as BP respond
-give early in the day so that increased urination will not disturb sleep
-avoid IV use if oral is at all possible
-discard diluted solution after 24 hours
-refrigerate oral solution
-measure and record weight to monitor fluid changes
-arrange to monitor serum electrolytes, hydration, liver, and renal function
-arrange for potassium-rich diet or supplemental potassium is needed
Name of Drug: Omeprazole 40mg IV q12
Time Given:
March 12 (6am and 6pm)
Omeprazole 40mg
IV OD
Time Given:
March 13 (6am)
March 14 (6am)
March 15 (6am)
Omoprazole 200mg 1tab BID
Time Given:
March 16 (6am)
Classification:
Antisecretory Drug, Proton Pump Inhibitor, Pregnancy Category C
Adverse Effect:
CNS: headache, dizziness, asthenia, vertigo, insomnia, apathy, anxiety,
paresthesias, dream abnormalities
Dermatologic: rash, inflamation, urticaria, pruritus, alopecis, dry skin
GI: diarrhea, abdominal pain, nausea, vomiting, constipation, dry mouth, tongue
atrophy
Respiratory: URI symptoms, cough, epistaxis
Other: cancer in preclinical studies, back pain, fever
Indication:
-short term treatment of active duodenal ulcer
-first-line therapy in treatment of heartburn or symptoms of GERD
-short –term treatment of active benign gastric ulcer
-to maintain healing of erosive esophagitis
-in combination to clarithromycin to eradicate H. pylori; use
clarithromycin and amoxicillinin combination with omeprazole in
patients with a 1 year history of duodenal ulcers or active duodenal
ulcers to eradicate H. pylori
-Zegerid oral suspension: reduction of risk of upper GI bleeding in
critically ill patients
-Prilosec OTC: treatment of frequent heartburn
Contraindication:
-contraindicated with hypersensitivity to omeprazole and its
components
-use cautiously with pregnancy and lactation
-combination therapy with clarithromycin should not be use in pt with
hepatic impairment
Nursing Consideration:
-take drugs before meals. Swallow the capsules whole; do not chew, open
or crush them. If using oral suspension, empty packet into a small cup
containing 2 tbsp of water. Stir and drink immediately; fill cup with water
and drink the water. Do not use any other liquid or food to dissolve
packet. This drug will need to be taken for up to 8wks (short term
therapy ) or for a long period (more than 5 yrs)
-if you take Prilosec capsules and cannot swallow them whole, capsules
contents will be added to or sprinkle with 1 tbsp of apple sauce. Mix with
apple sauce, swallow immediately with chewing pellets, and follow it with
a glass of water. Zegerid capsules should not be opened or added to
food
-have regular medical follow up visits.
-you may experience this side effects: dizziness, headache, nausea,
vomiting, diarrhea; symptoms are URI, cough
-report severe headache, worsening of symptoms, fever and chills
Name of Drug: Clarithromycin 500mg 1tab BID
Classification: Macrolide Antibiotic
Adverse Effect:
CNS: dizziness, headache, vertigo, somnolence, fatigue
GI: diarrhea, abdominal pain, nausea, dyspepsia, flatulence, vomiting,
melena, pseudomembranous colitis, abnormal taste
Other: superinfections, increased PT, decreased WBC
Indication:
-treatment of URIs caused by Streptococcus pyogenes, Streptococcus
pneumoniae
-treatment of lower respiratory infections caused by Mycoplasma pneumonia,
Haemophilus influenzae, Moraxella Catarrhalis
-treatment of skin and skin-structure infections caused by Staphylococcus
aureus and S. pyogenes
-treatment of active duodenal ulcer associated with H. pylori in combination
with proton pump inhibitor
Contraindication:
-contraindicated with hypersensitivity to clarithromycin, erythromycin, o any
macrolide antibiotic
-use cautiously with colitis, hepatic or renal impairment, pregnancy, lactation
Nursing Consideration:
-do not crush or cut, and ensure that pt does not chew ER tablets
-monitor pt for anticipated response
-take drug with food if G effects occur. Take the full course of
therapy
-do not drink grape fruit juice while taking this drug
-shake suspension before use; do not refrigerate; do not cut,
crush or chew extended release tablets; swallow them all
-you may experience these side effects: stomach cramping,
discomfort, diarrhea, fatigue, headache, additional infections in
the mouth or vagina
-report severe or watery diarrhea, severe nausea, vomiting, rash
or itching, mouth sores, vaginal sores
Name of Drug: Tranexamic Acid 1g IV q8
Time given:
March 12 (6am, 2pm, 6pm)
March 13 (6am, 2pm, 6pm)
March 14 (6am; stopped)
Adverse Effect:
-gastrointestinal disturbances
-hypotension, particularly after rapid IV administration. Thrombotic
complications have been reported. Instances of transient disturbance of
color vision associated with its use.
Indication:
-treatment and prophylaxis of hemorrhage associated with excessive
fibrinolysis
-prophylaxis of hereditary angioedema
Contraindication:
-hypersensitivity
-patients with active intravascular clotting because of the risk of thrombosis
-severe renal insufficiency
-patients with microscopic hematuria
Nursing Consideration:
Assessment:
-assess patients history, if with active intravascular clotting,
predisposed to thrombosis; hemorrhage due to disseminated
intravascular coagulation.
-monitor anti-coagulant cover
-perform eye examination
-perform liver function tests
-perform blood test
-obtain prothrombin time of the pt
-reduce dose for pt with renal impairment and children
IV injection or infusion: give 3x a day and maybe mixed with most
solutions but not with penicillins
-Should not be used in pt with active intravascular clotting
-possibility with skin reaction such as wide spread, patchy rash with
associated blisters
-advice pt to report visual abnormalities to the physician
Name of Drug: Amoxicillin 500mg
1tab TID
Classification: Antibiotic
(Penicillin- Ampicillin type)
Adverse Effect:
CNS: lethargy, hallucination, seizure
GI: glossitis, stomatitis, gastritis, sore mouth, furry tongue, nausea,
vomiting, diarrhea, abdominal pain, bloody diarrhea, enteroclolitis,
pseudomembranous colitis, non-specific hepatitis
GU: nephritis
Hematologic: anemia, thrombocytopenia, leucopenia, neutropenia,
prolonged bleeding time
Hypersensitivity: rash, fever, wheezing, anaphylaxis
Other: super infections- oral and rectal moniliasis, vaginitis
Indication:
-infections due to susceptible strains of Haemophilus influenza, E. coli,
Neisseria Gonorrhea, Streptococcus pneumoniae, Enterococcus fecalis,
Streptococci, non-penicillinase producing staphylococci
-H. pylori infection in combination with other agents
-post exposure prophylaxis against Bacillus Anthacis
Contraindication:
-contraindicated with allergies to penicillins, cephalosporins
and other allergens.
-use cautiously with renal disorders, lactation
Nursing Consideration:
-give in oral preparations only; amoxicillin is not affected by
food
-continue therapy for at least 2days after signs of infection
have disappeared; continuation for 10 full days is
recommended
-use corticosteroids or anti histamines for skin reactions
-take antibiotic around-the-clock
-this antibiotic is specific for this problem and should not be
used to self-treat other infections
-you may experience these side effects: nausea, vomiting, GI
upset, diarrhea, sore mouth
-report unusual bleeding or bruising, sore throat, fever, rash,
hives, severe diarrhea, DOB
Blood Chemistry (March 12, 2010)
SI Unit Traditional SI Unit Traditional Interpretation
Differential Count
Differential Count
Segmenters
Lymphocytes
Monocytes
Blood type
HbsAg
Others
Urinalysis
March 13, 2010
Interpretation
Color Yellow Normal
Characteristic Clear Normal
Reaction NO STRIP
SP. Gravity NO STRIP
Albumin NO STRIP
Sugar NO STRIP
Pregnancy Test NO STRIP
WBC 1-3 HPF (range: 0-5)
RBC 0-2 HPF (range: 0-3) Normal
Epith. Cell Few Normal
Cast
Bacteria Few May indicate infection
Crystals
Miscellaneous
Health perception/Health Management
Nutritional /Metabolic
Elimination
Activity/Exercise
Sleep/Rest
Cognitive Perceptual
Roles/Relationship
Self-Perception/Self-Concept
Coping/Stress Tolerance
Value/Belief
Sexuality/Reproductive
Assessment Diagnosis Planning Intervention Evaluation