The Urea Cycle: Eliminate Ammonium Ion Via The Urea Cycle. Urea Is Excreted in The Urine
The Urea Cycle: Eliminate Ammonium Ion Via The Urea Cycle. Urea Is Excreted in The Urine
carbamoyl phosphate
Reaction requires ATP and H2O
Takes place in the mitochondria
Catalyzed by carbamoyl phosphate synthase
Step 2
Carbamoyl phosphate condenses with the
amino acid ornithine to produce the amino acid
The Urea Cycle
citrulline
Occurs in the mitochondria
Catalyzed by ornithine transcarbamoylase
Step 3
Citrulline is transported to the cytoplasm
Condenses with aspartate to produce
The Urea Cycle
argininosuccinate
Catalyzed by argininosuccinate synthase
Requires energy released by ATP hydrolysis
Step 4
Argininosuccinate cleaved to produce the
amino acid arginine and fumarate of the citric
The Urea Cycle
acid cycle
Reaction catalyzed by argininosuccinate lyase
Step 5
Final reaction hydrolyzes arginine to generate
urea the reaction product that is excreted
The Urea Cycle