Bone Development and It'S Microscopic Structure
Bone Development and It'S Microscopic Structure
Bone Development and It'S Microscopic Structure
ITS MICROSCOPIC
STRUCTURE
dr. Ni Made Linawati, M.Si /dr. I G K Nym
Arijana
Histology department
Medical Faculty of Udayana University
hyaline
Type
elastic
fibrocartilage
BONE
long
short
flat
Shape
irregular
sesamoid
Element
cells
matrix
Growth
interstitial
appositio
nal
Element
cells
matrix
Growth
appositional
intramembraneous
endochondral
Ossification
Matrix/Ground
Substance
Perichondri
um
Secreted by condroblast
:
Outer
fibrous layer
Amorphous
- fibroblast
elasti
collagen
- proteoglycan
c
condrocyt
- blood vessel
- glycoprotein
esIsogenous
Inner fibrous layer
(in cell group
hyali
- glycosaminoglycan- chondrogenic cells
lacuna)
- condro/osteoclast
Fibres
ne
blood
vessel
(macrophages)
for
only in
Matrix :
avascular
cartilage
- territorial
Exception
endochondral
fibrocartila
- interteritorial
-matrix
fibrocartilage
bone
- articular cartilage
ge
formation
diffusion of nutrient by
synovial
fluid
- condroblast
Matrix/Ground
Substance
Location
Elastic cartilage
Condrocytes >>>
Condrocytes
Collagen type II
Collagen type I
rich in dermatan
and condroitin
sulfate
Articular
trachea
bronchus
epiphyseal plate
Hyaline cartilage
The growth of
cartilage
Origin
Occur
Interstitial
growth
Resulting from the
mitotic division of
preexisting
chondrocytes
Early phase of cart
form, art. Cart,
epiphyseal plate
Type of cart
all
Appositional
growth
BONE
osteoblast
osteocytes
Matrix
Secreted by osteoblast
Organic matrix :
proteoglycan
glycoprotein
in lacuna
canaliculi
haversian systems
Osteoclast
howships lacuna
glycosaminoglycan
type I collagen
Inorganic matrix:
ca hydroksiapatite crystal
Decalsification by acid
secret acid enzymes
Ruffled border
Spongy
Bone
Cavities (+)
Bone development
Cellular differentiation
Bone matrix formation
Morphologic differentiation
Futher diferentiation of
woven to lamellar bone
: mesenchymal cell
osteoprogenitor cell
osteoblast
: osteoid
matrixcalsification
: formation of bone
spiculae , trabeculae,
spongy bone, and formation
of compact bone by
appositional lamellae
deposition
Bone formation
Intramembraneous
-Mesenchymal cell
osteoprogenitor
cellosteoblast
- Flat bone : calvaria of the
skull, mandible, periosteum of
shaft of long bone
- Need periosteum
Endochondral
- Cartilage model formation
- Bone collar development
-Destruction of cartilage model
followed by osteogenic bud
associated
with hemopoietic tissue in the
space of
destruction
-cartilage
Primary and
secondary
Center of
ossification
- Most of the long bone
Bone growth
In length
- Occur in epiphyseal plate
In width
- Appositional growth
- Continously througout
the total period of bone
growth and development
Summary
Cartilage VS Bone similarities
Development begin at embryo in 5 week of age
1.Hard tissue
2.Lacuna matrix systems
3.Same family of cellular components
Chondroblast chondrocytes
Osteoblast-osteocytes
4. Surrounded by connectiveTissue membrane
Perichondrium and periosteum
Summary
Difference
Cartilage
Bone
1. Inorganic
substance
2. Flexibility
3. Blood vessel
4. Nutrient supply
5. Mechanism of
growth
6. Remodelling
7. Destruction cell
No
Yes
Avascular
Diffusion
Interstitial &
appositional
No
No
High
No
Vascular
Canaliculi
Only appositional
Constantly
Osteoclast
Thank You
vignette
A boy 2 years old came to outpatient clinic
with complain pale, abcess and bleeding. He
got blind since his birth. Examination found
pansitopenia, sclerotic and increase of bone
mass. Doctor diagnosed with osteopetrosis.
a.Describe the pathophysiology of
osteopetrosis ?
b.Describe histological appearance in
osteopetrosis.