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    Helminth

    Uploaded by

    Amanda Powers
    This document discusses various helminth (parasitic worm) infections and their effects. It describes how helminths can mechanically interfere with host tissue and organs, induce inflammation and damage, consume host nutrients, introduce other pathogens, and secrete toxic substances. Immune responses to helminths include antibodies and cellular immunity. Specific parasites mentioned include the roundworm Ascaris, which can migrate through organs and cause lesions, and hookworms, which penetrate the skin or are ingested and migrate to the intestines, causing blood loss, anemia and intestinal damage. The effects of gastrointestinal parasites on hosts include traumatic damage, tissue proliferation, inflammation, granuloma formation and more.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd

    Helminth

    Uploaded by

    Amanda Powers
    185 views13 pages
    This document discusses various helminth (parasitic worm) infections and their effects. It describes how helminths can mechanically interfere with host tissue and organs, induce inflammation and damage, consume host nutrients, introduce other pathogens, and secrete toxic substances. Immune responses to helminths include antibodies and cellular immunity. Specific parasites mentioned include the roundworm Ascaris, which can migrate through organs and cause lesions, and hookworms, which penetrate the skin or are ingested and migrate to the intestines, causing blood loss, anemia and intestinal damage. The effects of gastrointestinal parasites on hosts include traumatic damage, tissue proliferation, inflammation, granuloma formation and more.

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    Helminth.ppt

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    This document discusses various helminth (parasitic worm) infections and their effects. It describes how helminths can mechanically interfere with host tissue and organs, induce inflammation and damage, consume host nutrients, introduce other pathogens, and secrete toxic substances. Immune responses to helminths include antibodies and cellular immunity. Specific parasites mentioned include the roundworm Ascaris, which can migrate through organs and cause lesions, and hookworms, which penetrate the skin or are ingested and migrate to the intestines, causing blood loss, anemia and intestinal damage. The effects of gastrointestinal parasites on hosts include traumatic damage, tissue proliferation, inflammation, granuloma formation and more.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    185 views13 pages

    Helminth

    Uploaded by

    Amanda Powers
    This document discusses various helminth (parasitic worm) infections and their effects. It describes how helminths can mechanically interfere with host tissue and organs, induce inflammation and damage, consume host nutrients, introduce other pathogens, and secrete toxic substances. Immune responses to helminths include antibodies and cellular immunity. Specific parasites mentioned include the roundworm Ascaris, which can migrate through organs and cause lesions, and hookworms, which penetrate the skin or are ingested and migrate to the intestines, causing blood loss, anemia and intestinal damage. The effects of gastrointestinal parasites on hosts include traumatic damage, tissue proliferation, inflammation, granuloma formation and more.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 13

    Disease Caused by Parasitic

    Helminths
    May AlsoVector for Other infectious Organism

    Effects of helminth Upon the Host


    1.
    2.
    3.
    4.
    5.
    6.
    7.
    8.

    Mechanical interfere with function


    Invade n displace cell and tissue, producing
    necrosis n loss function
    Devour blood n cause anemia
    Utilize food needed by the host
    Induce or predispose to neoplasia
    Introduce bacterial or other inf. Into tissue host
    Devour tissue of host
    Secrete toxic product (hemolysins, histolysins,
    antikoagulan).

    Immunity to Parasite
    Humoral antibody respons
    Cellular hypersensitivity (delayed

    immunity)
    Expultion of adult and larva stage
    Direct interaction : antibody or T-memory
    Immune induction nonspesific inflamatory
    Most evident suggest that delayed
    immune respons mediated by T-cell

    Ascariasis ( common roundworm infection,


    Ascarid worm infection)
    Lession by migration pattern
    1. Inf. Larva penetrate intestinal wall

    liver
    lung, break alveoli gain bronchi ascend
    trachea swall develop in intestinal
    lument
    2. Larva migrate not only through liver and
    lung bur olso in tissue prenatal infection in
    fetus
    3. Larva penetrated the wall of intestine

    Obtruction in bile ichterus


    Adult ascaris obstruction of intestinal lument,
    fatal in young
    Peritonitis
    Liver: Intents inflamation, edema, neutrophil,
    eosinophil, limfosit (as component inflamatory
    reaction), larva caseus necrosis
    In swine: difuse subscapula fibrosis (liver)
    In lung: few residual, hemorhages: capiler to alveoli,
    in heavy infestion: loss bronchiolar epitellium and
    infiltrasi leukosit.
    Produce nodule granulomateus in many site
    (kidney, lung, eye, miocardium, brain, lymp node)

    Ancylostomiasis (Hookworm Disease)

    1.
    2.
    3.
    4.
    5.
    6.
    7.

    Cosmopolitan in distribution
    Pathological effect:
    Buccal cavity like tooth
    Penetrasi by skin or ingestion
    To lung, gain intestine via tracheal
    Some larva may be carried by blood
    Penetrasi in epidermis spesifick
    dermatitis ( creeping eruption)
    Fetal infection
    Appear in milk ( Ancylostoma caninum)

    Clinical manifestation

    Secret anticoagulan and inhibit platelet aggregrat


    Enteritis and loss of blood to anemia
    Hyperplasia of the hemapoitik elemen in bone
    morrow
    Accompanied metaplasia in the spleen
    Blunting and fision of intestinal villi
    Inflamation and fibrosis of the lamina propria
    Defectif nutrient absorbtion
    At necropsi adult worm in small intestine
    Mic: larva may in tissue section

    andcause
    Clinical
    Signs
    Pathogenesis
    Developing larvae can
    blood loss

    (anemia),
    acute gastritis with nodule formation.
    Adult worms may be associated with chronic
    catarrhal gastritis.
    Clinical signs may include decreased feed
    intake,
    weight loss or decreased weight gain, diarrhea,
    and/or agalactia in nursing sows.

    Local effects of GI parasite in host


    EFFECTS

    AGEN

    Traumatic damage

    Hookworm

    Lysis necrosis

    Entamoeba histolitican

    Tissue proliferation, inflamation

    Numerous species

    Granuloma formation

    Shistosoma mansoni

    Altered villus

    Niprostrongulus brazilensis

    Altered smooth muscle

    Ascaris lumbricoides

    Mechanical obtruction

    Ascaris lumbricoides

    Intestinal enzym deficiency

    Numerous species

    Impired obstruction

    Giardia lambia

    Altered respons to GI hormon

    Trichinella spiralis

    Intestinal secretion

    Trichinella spiralis

    Compotition for nutrients

    Diphyllobothrium latum

    Altered mobility

    Numerus species

    Hypersensitivity

    Numerus species

    TAPE WORM

    NODULE WORM

    Schistosoma mansoni

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