Kuby Immunology, 7e: Chapter 2: Cells, Organs, and Microenvironments of The Immune System
Kuby Immunology, 7e: Chapter 2: Cells, Organs, and Microenvironments of The Immune System
Kuby Immunology, 7e: Chapter 2: Cells, Organs, and Microenvironments of The Immune System
In adult vertebrates,
hematopoiesis occurs in
the bone marrow
Erythrocytes
Monocytes
Granulocytes
Megakaryocytes
Granulocytes
Myeloid
AntigenPresenting Cells
Dendritic Cells
Follicular
Dendritic
Cells
Dendritic cells are the most potent antigenpresenting cells for activating nave T cells
B lymphocytes
T lymphocytes
NK cells
Bone Marrow
Site of T cell origin and B cell origin and
development (humans)
Bursa of Fabricus
Peyers patch
Lymph nodes
Spleen
Mucosa-associated lymphoid tissue (MALT)
Other diffuse and loosely organized areas
T lymphocytes
Both B and T lymphocytes will develop into longlived memory cells in these areas, as well
MALT
Various loosely
organized and
diffuse lymphoid
tissue are also
found under the
skin, mucosae,
and tertiary
tissues at sites of
infection
Evolutionary Comparisons
Lymphoid Cells and Organs
Summary