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Steps in The Synthesis and Secretion of Thyroid Hormone: Process Diagrams Step-by-Step

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rambabs369

The document outlines the 8 step process of thyroid hormone synthesis and secretion, including iodide trapping, thyroglobulin synthesis, iodination of tyrosine, coupling of iodotyrosines, pinocytosis and digestion of colloid, secretion of thyroid hormones, and transport in blood.

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Steps in The Synthesis and Secretion of Thyroid Hormone: Process Diagrams Step-by-Step

Uploaded by

rambabs369
95 views9 pages
The document outlines the 8 step process of thyroid hormone synthesis and secretion, including iodide trapping, thyroglobulin synthesis, iodination of tyrosine, coupling of iodotyrosines, pinocytosis and digestion of colloid, secretion of thyroid hormones, and transport in blood.

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THYROID

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THYROID

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© Attribution Non-Commercial (BY-NC)

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The document outlines the 8 step process of thyroid hormone synthesis and secretion, including iodide trapping, thyroglobulin synthesis, iodination of tyrosine, coupling of iodotyrosines, pinocytosis and digestion of colloid, secretion of thyroid hormones, and transport in blood.

Copyright:

Attribution Non-Commercial (BY-NC)
Download as PPT, PDF, TXT or read online from Scribd
Download as ppt, pdf, or txt
95 views9 pages

Steps in The Synthesis and Secretion of Thyroid Hormone: Process Diagrams Step-by-Step

Uploaded by

rambabs369
The document outlines the 8 step process of thyroid hormone synthesis and secretion, including iodide trapping, thyroglobulin synthesis, iodination of tyrosine, coupling of iodotyrosines, pinocytosis and digestion of colloid, secretion of thyroid hormones, and transport in blood.

Copyright:

Attribution Non-Commercial (BY-NC)
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Steps in the Synthesis and Secretion of Thyroid Hormone

Process Diagrams Step-by-Step

Copyright 2007 by John Wiley & Sons, Inc.

Portion of thyroid follicle Colloid Follicular cell Blood capillary

I I

I I I

I I I

1 Iodide trapping I I I Blood plasma

Key: I= Iodide; I2= Iodine Blood capillary TGB = thyroglobulin TBG = thyroxine-binding globulin

Portion of thyroid follicle Colloid Follicular cell Blood capillary

TGB

Secretory vesicles

Golgi complex
I I I 1 Iodide trapping I I I Blood plasma I I I I I 2 Synthesis of TGB Rough ER

Key: I= Iodide; I2= Iodine Blood capillary TGB = thyroglobulin TBG = thyroxine-binding globulin

Portion of thyroid follicle Colloid Follicular cell Blood capillary

3 Oxidation of iodide I2 TGB

Secretory vesicles

Golgi complex
I I I 1 Iodide trapping I I I Blood plasma I I I I I 2 Synthesis of TGB Rough ER

Key: I= Iodide; I2= Iodine Blood capillary TGB = thyroglobulin TBG = thyroxine-binding globulin

Portion of thyroid follicle 4 Iodination of tyrosine Colloid Follicular cell Blood capillary

Tyrosine

3 Oxidation of iodide I2 TGB

Secretory vesicles

Golgi complex
I I I 1 Iodide trapping I I I Blood plasma I I I I I 2 Synthesis of TGB Rough ER

Key: I= Iodide; I2= Iodine Blood capillary TGB = thyroglobulin TBG = thyroxine-binding globulin

Portion of thyroid follicle 4 Iodination of tyrosine Colloid Follicular cell Blood capillary

5 Coupling of T1 and T2

Tyrosine

T1

T2

T4 3 Oxidation of iodide I2 TGB Colloid T3

Secretory vesicles

Golgi complex
I I I 1 Iodide trapping I I I Blood plasma I I I I I 2 Synthesis of TGB Rough ER

Key: I= Iodide; I2= Iodine Blood capillary TGB = thyroglobulin TBG = thyroxine-binding globulin

Portion of thyroid follicle 4 Iodination of tyrosine Colloid Follicular cell Blood capillary

5 Coupling of T1 and T2

Tyrosine

T1

T2

T4 3 Oxidation of iodide I2 TGB Colloid T3

6 Pinocytosis and digestion of colloid

Secretory vesicles

Lysosome

Golgi complex
I I I 1 Iodide trapping I I I Blood plasma I I I I I 2 Synthesis of TGB Rough ER

T3 T4

Key: I= Iodide; I2= Iodine Blood capillary TGB = thyroglobulin TBG = thyroxine-binding globulin

Portion of thyroid follicle 4 Iodination of tyrosine Colloid Follicular cell Blood capillary

5 Coupling of T1 and T2

Tyrosine

T1

T2

T4 3 Oxidation of iodide I2 TGB Colloid T3

6 Pinocytosis and digestion of colloid

Secretory vesicles

Lysosome

Golgi complex
I I I 1 Iodide trapping I I T3 I TBG Blood T TBG 4 plasma I I I I I 2 Synthesis of TGB

T3 T4 T3 T 4

Rough ER 7 Secretion of thyroid hormones

Key: I= Iodide; I2= Iodine Blood capillary TGB = thyroglobulin TBG = thyroxine-binding globulin

Portion of thyroid follicle 4 Iodination of tyrosine Colloid Follicular cell Blood capillary

5 Coupling of T1 and T2

Tyrosine

T1

T2

T4 3 Oxidation of iodide I2 TGB Colloid T3

6 Pinocytosis and digestion of colloid

Secretory vesicles

Lysosome

Golgi complex
I I I 1 Iodide trapping I I T3 I TBG 8 Blood T TBG 4 plasma I I I I I 2 Synthesis of TGB

T3 T4 T3 T 4

Rough ER 7 Secretion of thyroid hormones

Key: I= Iodide; I2= Iodine Blood capillary TGB = thyroglobulin TBG = thyroxine-binding globulin

Transport in blood

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