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Alex

This document provides information on the ingredients, mechanisms of action, indications, dosages, and formulations of various Alex cough and cold products. It describes the active ingredients like dextromethorphan hydrobromide, guaiphenesin, phenylephrine hydrochloride, chlorpheniramine maleate, and paracetamol. It also summarizes the various Alex formulations like cough lozenges, cough formula, sugar free syrup, cough-cold syrup, and paediatric drops that contain these ingredients to relieve cough, cold, fever, pain, and nasal congestion.

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328 views35 pages

Alex

This document provides information on the ingredients, mechanisms of action, indications, dosages, and formulations of various Alex cough and cold products. It describes the active ingredients like dextromethorphan hydrobromide, guaiphenesin, phenylephrine hydrochloride, chlorpheniramine maleate, and paracetamol. It also summarizes the various Alex formulations like cough lozenges, cough formula, sugar free syrup, cough-cold syrup, and paediatric drops that contain these ingredients to relieve cough, cold, fever, pain, and nasal congestion.

Uploaded by

kurutala
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd
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Ingredients in Alex

Dextromethorphan Hydrobromide Guaiphenesin Phenylephrine Hydrochloride Chlorpheniramine maleate Paracetamol

Dextromethorphan Hydrobromide (DMR)


Non - narcotic cough suppressant (anti tussive). Acts centrally on cough centre, (Medulla) and elevates the threshold for coughing. Equipotent to codeine in depressing cough reflex.

Average dose is 10 to 30 mg 3 to 6 times daily.


Exerts effect within 15-30 minutes after oral administration. Duration of action is 5-6 hours.
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Favorable Features of Dextromethorphan Hydrobromide


Equipotent antitussive to Codeine, Pholcodiene which are narcotic. No addictive properties. Does not cause CNS depression nor it affects respiratory rate. Does not cause drowsiness, constipation unlike codeine. Is safe & effective.

Guaiphenesin
Most commonly used expectorant. Increases the output of respiratory tract fluids, this helps to liquefy the thick mucus. Though not a cough suppressant reduces the intensity and frequency of dry or productive cough.

Phenylephrine Hydrochloride
It is oral nasal decongestant.

Phenylephrine effects its vasoconstrictor activity by releasing noradrenaline from sympathetic nerve endings and from direct stimulation of (alpha)-adreno receptors in blood vessels.
Half-life is approximately 2-3 hrs. Drug is eliminated primarily as metabolites in urine (8086%).

Phenylephrine Hydrochloride Stimulates Symphathetic adrenergic nerve endings Norephinephrine Alpha & Beta receptors

Mode of Action

Vasoconstriction Acts as Nasal Decongestant

Dosage
Phenylephrine Hydrochloride Adult: 10 mg every 4 hours

Children: 0.15mg/kg mg every 4 hours

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Paracetamol
Effective alternative to aspirin as analgesic & antipyretic.

Less toxicity and most widely preferred.


Rapidly and completely absorbed from GI tract.

Peak plasma concentration reaches within 30-60 minutes


Plasma Half-life is about 2 hours after therapeutic dose.

Chlorpheniramine Maleate
H1 receptor antagonist. One of the most potent antihistamines. One of the most effective and least toxic antihistamine.

Effective in relatively low doses (2mg-4mg).


Prevents histamine from dilating capillaries that causes oedema of respiratory mucosa. Promptly relieves symptoms in Rhinitis (sneezing, itching of eyes, nose & throat).
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Dosage
Chlorpheniramine Maleate

In children upto 1 year dose is 1mg twice daily. For those aged 1 to 5 years 1 to 2 mg three times daily. For 6 to 12 years, 2 to 4 mg 3 or 4 times daily.

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Alex Cough Lozenges


Composition
Each Lozenge contains : Dextromethorphan Hydrobromide I.P. 5 mg Sugar base q. s.

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Alex Cough Lozenges


Profile
Unique product, was introduced for the first time in India. Word 'Lozenges' is from old French word 'Lauze' meaning a flat stone.

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Alex Cough Lozenges


Profile
The medical definition of Lozenges is tablet containing medication in flavoured and sweetened base.

Designed for local treatment of throat by slow & steady release of the medicine in the mouth.

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Actions of Alex Cough Lozenges


Demulcent Action base of Lozenges offer protective barrier over inflamed mucous membrane. Promote mucus secretion : an important defense mechanism of respiratory tract. Provides longer contact time with mucous membrane - unlike with syrup preparations.
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Alex Cough Lozenges


Indications
Mainly used for non-productive, irritative cough.
When antitussive action & demulcent action is required.

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Alex Cough Lozenges


Dosage
Adults and children above 12 years Children 6 to 12 years 4 to 6 years < 4 years : 1-2 Lozenges every 68hours.

: : :
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1 Lozenge 3-4 times a day. As directed by Physician. Not recommended.

Available in strip of 10s. 10 strips are in an outer carton.


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Alex Cough Formula


Composition
Each 5 ml contains : Guaiphenesin Dextromethorphan Hydrobromide Phenylephrine 100 mg 10 mg 5 mg

Chlorpheniramine maleate
Flavoured base
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4 mg
q.s.

Alex Cough Formula


Indications
Recommended in cases of Productive Cough and cold due to LRTI. i.e. to tackle various types of cough and associated symptoms.

Alex Cough Formula


Dosage
Adults & Children: Above 12 years teaspoonful(10 ml) 3-4 times a day. 2

6 years to 11 years- 1 teaspoonful(5 ml) 3-4 times a day. 1 year to 5 years - 1/2 teaspoonful(2.5 ml) 3-4 times a day.

Less than 1 yr- Not recommended.


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Alex Cough Formula


Precautions
Patients should be advised to abstain from taking alcohol or other CNS depressants concomitantly.

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Available in 50 & 100 ml pet bottles.

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Alex Sugar Free Syrup


Rationale
Ideal for ...
Diabetic patients

Calorie Conscious patients


Patients with dental problems

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Alex Sugar Free Syrup


Choice of Sweetener
ALEX Sugar Free is sweet and palatable: Due to SORBITOL (70% w/w) in place of sugar.

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Available in 50 ml pet bottle


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Alex-P Syrup
Composition
Each 5ml contains :
Paracetamol Dextromethorphan Hydrobromide Phenylephrine Hydrochloride Chlorpheniramine Maleate Flavoured base
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170mg 5mg 2.5mg 1.5mg q.s

Alex-P Syrup
Indications
Indicated in the treatment of cold,
fever, and pain relief in rhinitis,

pharyngitis, upper respiratory tract


infections and sinusitis.

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Alex-P Syrup
Dosage
Adults

& Children: Above 12 years - 2 teaspoonful(10 ml) 3-4 times a day.


6 years to 11 years- 1 teaspoonful(5 ml) 3-4 times a day. 1 year to 5 years - 1/2 teaspoonful(2.5 ml) 3-4 times a day.

Less than 1 yr- Not recommended.


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Available in bottle of 60 ml pet bottle with a measuring cap.

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Alex Paediatric Drops


Composition
Each ml contains :
Phenylephrine Hydrochloride 2.5 mg

Chlorpheniramine Maleate
Flavoured base

2 mg
q.s.

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Alex Paediatric Drops


Rationale
Phenylephrine is most frequently used decongestants, equipotent to ephedrine, with less CNS stimulation.

Chlorpheniramine Maleate possesses good antihistaminic activity with less sedative and anticholinergic effects.
Both together clear a blocked nose.
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Alex Paediatric Drops


Indications
Recommended for the symptomatic relief of colds the and nose allergic or symptoms throat and including itchy, running nose, stuffy nose, sneezing, itching of water eyes.
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Alex Paediatric Drops


Dosage
4 - 12 months hours 12 - 24 months hours 0.6 ml every 4 to 6 1.25 ml every 4 to 6

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Available in 15 ml bottle with dropper.


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