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    Biochem 158/258 and Humbio 158G: Doug Brutlag Professor Emeritus Biochemistry and Medicine (By Courtesy)

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    Johnny Rodriguez
    This document provides an overview and syllabus for the course "Genomics Bioinformatics & Medicine" taught by Doug Brutlag at Stanford University. The course covers topics like sequencing the human genome, identifying genetic variations associated with disease, stem cell therapies, and ethical issues in genetics. It requires students to complete four research assignments on disease analysis, functional genomics, genome-wide association studies, and a final project. The course aims to explore how genomics is impacting medicine in areas like diagnostics, therapeutics, and preventive healthcare.

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    Biochem 158/258 and Humbio 158G: Doug Brutlag Professor Emeritus Biochemistry and Medicine (By Courtesy)

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    Johnny Rodriguez
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    This document provides an overview and syllabus for the course "Genomics Bioinformatics & Medicine" taught by Doug Brutlag at Stanford University. The course covers topics like sequencing the human genome, identifying genetic variations associated with disease, stem cell therapies, and ethical issues in genetics. It requires students to complete four research assignments on disease analysis, functional genomics, genome-wide association studies, and a final project. The course aims to explore how genomics is impacting medicine in areas like diagnostics, therapeutics, and preventive healthcare.

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    This document provides an overview and syllabus for the course "Genomics Bioinformatics & Medicine" taught by Doug Brutlag at Stanford University. The course covers topics like sequencing the human genome, identifying genetic variations associated with disease, stem cell therapies, and ethical issues in genetics. It requires students to complete four research assignments on disease analysis, functional genomics, genome-wide association studies, and a final project. The course aims to explore how genomics is impacting medicine in areas like diagnostics, therapeutics, and preventive healthcare.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    27 views19 pages

    Biochem 158/258 and Humbio 158G: Doug Brutlag Professor Emeritus Biochemistry and Medicine (By Courtesy)

    Uploaded by

    Johnny Rodriguez
    This document provides an overview and syllabus for the course "Genomics Bioinformatics & Medicine" taught by Doug Brutlag at Stanford University. The course covers topics like sequencing the human genome, identifying genetic variations associated with disease, stem cell therapies, and ethical issues in genetics. It requires students to complete four research assignments on disease analysis, functional genomics, genome-wide association studies, and a final project. The course aims to explore how genomics is impacting medicine in areas like diagnostics, therapeutics, and preventive healthcare.

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    Genomics Bioinformatics & Medicine

    http://biochem158.stanford.edu/
    Biochem 158/258 and HumBio 158G

    Doug Brutlag Professor Emeritus Biochemistry and Medicine (by courtesy) [email protected]
    Doug Brutlag 2011

    Greg Gibson & Spencer V. Muse

    A Primer of Genome Science

    $62
    Doug Brutlag 2011

    Greg Gibson

    It Takes a Genome

    Doug Brutlag 2011

    Course Syllabus
    http://biochem158.stanford.edu/
    Sept 27 Sept 29 Oct 4 Oct 6 Oct 11 Oct 13 Oct 18 Oct 20 Oct 25 Oct 27 Nov 1 Nov 3 Nov 8 Nov 10 Nov 15 Nov 17 Nov 29 Introduction to Genes, Diseases and Preventive Medicine Diseases and Disease Databases Sequencing the Human Genome Finishing the Human Genome Next Generation Sequencing Methods Bioinformatics and Functional Genomics Sequence Variations in the Human Genome Structural Variations: Insertions, deletions, transpositions, & copy number variations. Discovering Variations Associated with Disease Discovering Causal Mutations for Disease Personal Genomics Stem Cells Stem Cell Therapies Gene Expression and Cancer Diagnostics Epigenetics Drug Development Pharmacogenomics

    Dec 1

    Ethical Issues and Genetic Discrimination

    Doug Brutlag 2011

    Course Requirementshttp://biochem158.stanford.edu/
    Four research assignments
    Disease case presentation Bioinformatics analysis of gene function Description of a genome-wide association study Final project (paper or presentation) on
    The molecular basis of a disease A novel diagnosis or treatment of a disease A technological advance in genomics & disease An ethical, legal or social issue in genomics or medicine

    Participation in Class Discussion

    Doug Brutlag 2011

    Research Projects and Grading Policy


    http://biochem158.stanford.edu/
    Assignment % of Grade Date Due

    Inherited Disease Case Presentation


    Functional Analysis of a Human Gene Review of Genome-Wide Association Studies Final Project on Genomics and Medicine

    20%
    20% 20% 40%

    Oct. 11
    Oct. 25 Nov. 8 Dec. 9

    Second chance on homework!

    Doug Brutlag 2011

    Cognate Courses
    Undergraduate Courses Biochem 118 Genomics and Medicine Sophomore Seminar Bio 109A and 109B (HumBio 158A and B) The Human Genome and Disease HumBio 157 The Biology of Stem Cells HumBio 159 Genes and Environment in Disease Causation Graduate Level Courses Genetics 210 Genomics and Personalized Medicine Genetics 211 Genomics CS 262 Computational Genomics CS 273A A Computational Tour of the Human Genome Biochem 218/BMI 231 Computational Molecular Biology BMI 214/CS 274 Representations and Algorithms for Computational Molecular Biology
    Doug Brutlag 2011

    BioMedical Seminars
    Biomedical Seminars Calendar

    Frontiers in Biology Seminar Series


    Atul Butte, Stanford
    Exploring Systems and Personalized Medicine Through Translational Bioinformatics Sep 28 4:00 PM Clark Center Auditorium

    Nick Schork, Scripps


    Functional Genomic Variants and Human Diversity Oct 26 4:00 PM Clark Center Auditorium

    Marisa Bartolomei, U of Pennsylvania


    Epigenetic regulation of genomic imprinting Nov 16 28 4:00 PM Clark Center Auditorium

    Doug Brutlag 2011

    Leveraging Genomic Information


    Novel Diagnostics
    Microchips & Microarrays - DNA Gene Expression - RNA Proteomics - Protein

    Novel Therapeutics
    Drug Target Discovery Rational Drug Design Molecular Docking Gene Therapy Stem Cell Therapy

    Understanding Metabolism Understanding Disease


    Inherited Diseases - OMIM Infectious Diseases Pathogenic Bacteria Viruses

    Doug Brutlag 2011

    Impact of Genomics on Medicine I. Diagnostics


    Genomics: Identifying all known human genes Functional Genomics: Functional analysis of genes
    In what tissues are they important? When in development are the genes used? How are they regulated?

    Novel diagnostics
    Linking genes to diseases and to traits Predisposition to diseases Expression of genes and disease

    Personal Genomics
    Understanding the link between genomics and environment Increased vigilance and taking action to prevent disease Improving health care
    Doug Brutlag 2011

    Impact of Genomics on Medicine II. Therapeutics


    Novel Drug Development
    Identifying novel drug targets Validating drug targets Predicting toxicity and adverse reactions Improving clinical trials and testing

    Gene therapy
    Replacing the gene rather than the gene product

    Stem cells therapies


    Replacing the entire cell type or tissue to cure a disease

    Pharmacogenomics
    Personalized medicine Adjusting drug, amounts and delivery to suit patients Maximize efficacy and minimize side effects Identify genetics of adverse reactions Identify patients who respond optimally Doug Brutlag 2011

    Impact of Genomics on Medicine III. Ethical, Legal and Social Issues


    Personal Privacy Insurability Employability Discrimination Genetic selection versus eugenics Cosmetic genetics Patentability of genes, proteins and other natural products

    Doug Brutlag 2011

    Impact of Genomics on Medicine IV. Strategic


    Genomics can discover disease associated genes Genomics can discover disease causing genes. Genomics provides understanding of disease Genomics and bioinformatics provides basis for novel drug development Genomics provides basis for novel genetic and stem cell therapies Genomics provides the basis for preventive medicine.

    Doug Brutlag 2011

    Preventive Medicine

    Doug Brutlag 2011

    Founder of Preventive Medicine: Louis Pasteur

    When thinking about diseases, I never think about how to cure them, but instead I think about how to prevent them.
    Doug Brutlag 2011

    Preventive Medicine
    The goal is to prevent disease from occurring. First one must identify the cause of the disease. Treat the cause of the disease rather than the symptoms
    Example 1: Peptic Ulcers Example 2: Pyrogens

    Genomics identifies genetic causes of inherited disease. When Paul Wise (a Stanford pediatrician) heard that we may soon sequence every childs genome at birth, he stated:
    all medicine may soon become pediatrics!

    Overlooked accidents, infectious disease, auto immune disease and aging: environmental or acquired diseases Genetic penetrance and environment
    Doug Brutlag 2011

    Health Care Policy


    Current health care treats disease rather than maintaining health (Illness care?) Future health care prevent disease Reduce need for expensive interventions Need policies that incentivize patients and doctors to prevent disease. Need social pressures to control behavior and increase vigilance.

    Doug Brutlag 2011

    Huntington Disease Film

    Doug Brutlag 2011

    The Inheritance
    You are 18 years old. Your father abandoned you and your mother when you only 2 years old. Your father died this year and left you an inheritance. He died from an autosomal dominant disease known as Huntingtons Chorea or Huntingtons Disease. You have a 50% chance of inheriting this invariably fatal neurodegenerative disease. But there is a genetic test for this disease that can tell you not only if you have the disease, and if you do, when you will die from it. Would you take the genetic test or not? Why?

    Doug Brutlag 2011

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